Protein Alignment l(3)72Dn and UTP4

DIOPT Version :10

• Sequence 1: NP_001261930.1
• Gene: l(3)72Dn / 39774
• FlyBaseID: FBgn0263605
• Length: 699
• Species: Drosophila melanogaster
• Sequence 2: NP_116219.2
• Gene: UTP4 / 84916
• HGNCID: 1983
• Length: 686
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 183/725 - (25%)
• Similarity: 337/725 - (46%)
• Gaps: 81/725 - (11%)

  Fly    13 GKHQVHNVRFYTIKPREIVSLAYSKSSKCLALSRATPVIELWNLEHAPYLDRVIHLPTDSHVESI 77
            |:.:||.|||:...|..|..:||:..|..||:||....:|::||....:.::..........|::
Human     2 GEFKVHRVRFFNYVPSGIRCVAYNNQSNRLAVSRTDGTVEIYNLSANYFQEKFFPGHESRATEAL 66

  Fly    78 AWA-GNRLFSVDLSGKLIEWDVIKLKQRYEHSPTGNALWSIDVNPAETDIAIGSEEGHINILSIE 141
            .|| |.||||..|:|:::|:|:..|..:|.....|..:||:..:|:.:.:.:|.|:|.:.:..|.
Human    67 CWAEGQRLFSAGLNGEIMEYDLQALNIKYAMDAFGGPIWSMAASPSGSQLLVGCEDGSVKLFQIT 131

  Fly   142 NDEITYKSLFNKQKGRVLCIKFDKTGTKLVTGTEGFVRIWNVLKGTTLHTMT-------LSEKNV 199
            .|:|.::..|::||.|:|.:.:..:||.:..|:..::.:::|..|:.:|.|.       :|::..
Human   132 PDKIQFERNFDRQKSRILSLSWHPSGTHIAAGSIDYISVFDVKSGSAVHKMIVDRQYMGVSKRKC 196

  Fly   200 IVWSLQVLSDNTIIAGDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKEDRLVCSGMQPPLI 264
            |||.:..|||.|||:.||||.|..||:...|.:.|..:.:.:|.::||.::||..|. |.....:
Human   197 IVWGVAFLSDGTIISVDSAGKVQFWDSATGTLVKSHLIANADVQSIAVADQEDSFVV-GTAEGTV 260

  Fly   265 RIFSKTKIKREESTSERWIKFLQRDAHKHYVKSLLVIDDQIYSGGRDGILTITS-SERMQAHLSQ 328
            ..|....: ...|:.::|::......|.|.|:::......:.|||.|..|.... .|:::.....
Human   261 FHFQLVPV-TSNSSEKQWVRTKPFQHHTHDVRTVAHSPTALISGGTDTHLVFRPLMEKVEVKNYD 324

  Fly   329 HA----PFLKGSVASMAISKKLLLLRYPNSVHLWRLGSVAPQGEDKKKPWALPVGHTEEQLLELP 389
            .|    .|....:.|.:..::|||.::.:.:.||||||....|::         |.|      ||
Human   325 AALRKITFPHRCLISCSKKRQLLLFQFAHHLELWRLGSTVATGKN---------GDT------LP 374

  Fly   390 PQK----LLQLNVKEHNFIQSAAISSDANWICYSTLKELRISRL--KSDPLQVERLVDDLPEELQ 448
            ..|    ||.|..|....|..:.||...:||.|||:....:.||  :.|.:.::| |..:|..|:
Human   375 LSKNADHLLHLKTKGPENIICSCISPCGSWIAYSTVSRFFLYRLNYEHDNISLKR-VSKMPAFLR 438

  Fly   449 PASHIIFTK----------QGDLVLLNPQN---NHLSWFTLEEDLVTFKYTIDLSEKCKNTISHV 500
            .|..|:|::          ||.|.::....   .||..|..:...|             ..:..:
Human   439 SALQILFSEDSTKLFVASNQGALHIVQLSGGSFKHLHAFQPQSGTV-------------EAMCLL 490

  Fly   501 VISSHGEYIVAASSDHIISVWKLHGKQYKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQLVEY 565
            .:|..|.::.|:.:...:.|:.:  ||.|....:|.:....||:::..:...:|:|:::.|:.||
Human   491 AVSPDGNWLAASGTSAGVHVYNV--KQLKLHCTVPAYNFPVTAMAIAPNTNNLVIAHSDQQVFEY 553

  Fly   566 DLVNRIFTCETNEYLIPETRRHC-------INGISLDPQNRNIFIVHTEGNLYVLERDQHL-DPK 622
            .:.::.:| :.:..:..:...|.       |..||..|:.....::|......::::...| :.|
Human   554 SIPDKQYT-DWSRTVQKQGFHHLWLQRDTPITHISFHPKRPMHILLHDAYMFCIIDKSLPLPNDK 617

  Fly   623 ELVSNSKSKKLSNGNRSSVDGGSKGLSLKTTLSRQVRLHLVHVSRLSPNELVNVSISTNNLLAPL 687
            .|:.|    .....|.|.|.......:.|.:   ::...|:.:..|....||.|....::::|.|
Human   618 TLLYN----PFPPTNESDVIRRRTAHAFKIS---KIYKPLLFMDLLDERTLVAVERPLDDIIAQL 675

  Fly   688 PPPYQRKKFG 697
            |||.::||||
Human   676 PPPIKKKKFG 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Dn	NP_001261930.1	WD40	<30..258	CDD:441893	72/235 (31%)
		WD40 repeat	74..106	CDD:293791	13/32 (41%)
		WD40 repeat	115..151	CDD:293791	9/35 (26%)
		WD40 repeat	158..193	CDD:293791	7/34 (21%)
		WD40 repeat	283..331	CDD:293791	10/52 (19%)
		WD40	290..>567	CDD:441893	71/300 (24%)
		WD40 repeat	453..489	CDD:293791	9/48 (19%)
		WD40 repeat	498..536	CDD:293791	7/37 (19%)
UTP4	NP_116219.2	WD40	<7..306	CDD:441893	87/300 (29%)
		WD 1	7..50		16/42 (38%)
		WD40 repeat	20..57	CDD:293791	10/36 (28%)
		WD 2	51..92		12/40 (30%)
		WD40 repeat	62..101	CDD:293791	14/38 (37%)
		WD 3	93..135		10/41 (24%)
		WD40 repeat	105..142	CDD:293791	9/36 (25%)
		WD 4	136..181		10/44 (23%)
		WD40 repeat	148..189	CDD:293791	8/40 (20%)
		WD 5	182..226		18/43 (42%)
		WD40 repeat	198..234	CDD:293791	17/35 (49%)
		WD 6	227..275		11/49 (22%)
		WD 7	276..317		9/40 (23%)
		WD40	286..547	CDD:475233	68/291 (23%)
		WD 8	318..377		17/73 (23%)
		WD40 repeat	334..374	CDD:293791	13/54 (24%)
		WD 9	378..427		15/48 (31%)
		WD 10	428..475		11/47 (23%)
		WD40 repeat	443..479	CDD:293791	8/35 (23%)
		WD 11	476..516		7/54 (13%)
		WD40 repeat	487..524	CDD:293791	7/38 (18%)
		WD 12	517..566		10/49 (20%)
		WD 13	567..627		10/63 (16%)
		WD 14	628..666		9/40 (23%)