DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Dn and PCN

DIOPT Version :9

Sequence 1:	NP_001261930.1	Gene:	l(3)72Dn / 39774	FlyBaseID:	FBgn0263605	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_567317.2	Gene:	PCN / 826172	AraportID:	AT4G07410	Length:	815	Species:	Arabidopsis thaliana

Alignment Length:	831	Identity:	172/831 - (20%)
Similarity:	300/831 - (36%)	Gaps:	241/831 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KPREIVSLAYSKSSKCLALSRATPVIELWNLEHAP---YLDRVIHLPTDSHVESIAWA------- 80
            ||..:|:||.|.....:|.:|....:|:|.:....   :....||...:|.:.|:||.
plant    12 KPSPVVALANSSDDSQVAAAREDGSLEIWLVSPGAVGWHCQLTIHGDPNSRISSLAWCCSPSIGL 76

  Fly    81 -GNRLFSVDLSGKLIEWDVIKLKQRYEHSPTGNALWSIDVNPA---ETDI--------------- 126
             ..||||..:.|.:.|||:..|||:......|.::|.:.:.|.   .:|:
plant    77 PSGRLFSSSIDGSISEWDLFDLKQKIVLESIGISIWQMALAPISGFSSDVEGIKNGYLSEKSNDE 141

  Fly   127 -AIGSEE--------------------------GHINILSIEN-DEITYKSLFNKQKGRVLCIKF 163
             .|||||                          |.:.:..|.| :::||.....:..||.|.:.:
plant   142 EEIGSEEDGSDSDEFHEKSEEEIDRILAAACDDGCVRLYRISNLEKLTYYRSLPRVSGRALSVTW 206

  Fly   164 DKTGTKLVTG-TEGFVRIWNVLKGTTLHTMTL------SEKNVIVWSLQVLSDNTIIAGDSAGFV 221
            .....::.:| ::|.:|.|:......::.:|.      |...:.||||..|..:.:::|||.|.|
plant   207 SPDAKRIFSGSSDGLIRCWDATSCHEVYRITAGLGGLGSSSEICVWSLLSLRCSVLVSGDSTGTV 271

  Fly   222 TVWDADNATQIDSTRVLDKNVFALAVNNKEDRLVCSGM--QPPLIRIFSKTKIKRE--ESTSERW 282
            ..||:::.|.:::......:|..||.....:|:..:|.  |..|.::...|...::  .|:|::|
plant   272 QFWDSEHGTLLEAHSNHKGDVNTLAAAPSHNRVFSAGADGQVILYKLSGSTNGSQDLKPSSSQKW 336

  Fly   283 IKFLQRDAHKHYVKSLLVI----------DD------------------------------QIYS 307
            .......||.|.:::|.|.          ||                              .:.|
plant   337 DYIGYVKAHTHDIRALTVAVPISREDPFPDDILPDKASRKHRKKGKPVDFTYHKWAHLGVPMLIS 401

  Fly   308 GGRDGILTITS---------------SERMQAHLSQHAPFLKGSVASMAISKKLLLLRYPNSVHL 357
            .|.|..|...|               .:|:...:..::.|.|.|         |||::..:::.:
plant   402 AGDDAKLFAYSIQEFTKFSPHDICPAPQRIPMQMVHNSMFNKTS---------LLLVQGISTLDI 457

  Fly   358 WRLG-SVAPQGEDKKKPWALPVGHTEEQLLELPPQKLLQLNVKEHNFIQSAAISSDANWICYS-- 419
            .||. |....|....|                   .|:::..::...|..:|||:..:...||
plant   458 LRLNISSDSSGRASTK-------------------SLVRVKSRDARKIICSAISNTGSHFAYSDQ 503

  Fly   420 ---TLKELRISRLKSDPLQVERLVDDLPEELQPASH-IIFTKQGDLVLLNPQNNHLSWFTLEEDL 480
               :|.||:.:.....|..|.|  ..|||  .|.:| :||:.....:::...:..:
plant   504 IGPSLFELKKNEFTKCPWSVSR--RRLPE--LPFAHSMIFSSDCSRLIIAGHDRRI--------- 555

  Fly   481 VTFKYTIDLSE--------------------KCKNTISHVVISSHGEYIVAASSDHIISVWKLHG 525
                ||||:|.                    ..:..|:.:..||.|:::.|.:....|.|:.|.
plant   556 ----YTIDISSLELVYAFTPSREEHEGEAPTPKEPPITKLFTSSDGQWLAAINCFGDIYVFNLE- 615

  Fly   526 KQYKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQLVEYDLVNRIFTCET-----------NEY 579
            .|.:|........|..||...|        .:.|..||.....|::|..:.           |.|
plant   616 TQRQHWFISRLDGASVTAAGFH--------PWNNNALVISTSSNQVFAFDVEARQLGKWSLLNTY 672

  Fly   580 LIPETRRHC---INGISLDPQ-NRNIFIVHTEGNLYVL------ERDQHLDPKELVSNSKSKKLS 634
            ::|:..:..   :.|:|..|. |.:..||::.....::      |.|:..|            |.
plant   673 VLPKRYQEFPGEVLGLSFSPSPNSSSVIVYSSRAKCLIDFGKPVEEDEEYD------------LP 725

  Fly   635 NGNRS-SVDGGSKGLSLK--TTLSRQVRLHLVHVSRLSPNELVNVSISTNN 682
            |||.| :::|....|.||  ...:|:.||....:...| ||..|..|..:|
plant   726 NGNLSKTLEGKLVNLGLKKGKGTNRKRRLDEYQLEGKS-NERKNFEILPSN 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Dn	NP_001261930.1	WD40	20..268	CDD:295369	70/307 (23%)
		WD40	57..529	CDD:225201	122/621 (20%)
		WD40 repeat	74..106	CDD:293791	14/39 (36%)
		WD40 repeat	115..151	CDD:293791	13/81 (16%)
		WD40 repeat	158..193	CDD:293791	5/35 (14%)
		WD40 repeat	283..331	CDD:293791	13/102 (13%)
		WD40 repeat	453..489	CDD:293791	5/35 (14%)
		WD40	<494..>603	CDD:295369	26/123 (21%)
		WD40 repeat	498..536	CDD:293791	9/37 (24%)
PCN	NP_567317.2	WD40	14..317	CDD:392136	68/302 (23%)
		WD40 repeat	16..56	CDD:293791	8/39 (21%)
		WD40 repeat	64..105	CDD:293791	14/40 (35%)
		WD40 repeat	201..244	CDD:293791	6/42 (14%)
		WD40 repeat	252..286	CDD:293791	12/33 (36%)
		WD40 repeat	536..570	CDD:293791	7/46 (15%)
		WD40 repeat	589..624	CDD:293791	9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	55	1.000	Domainoid score	I4114
eggNOG	1	0.900	-	-		E1_KOG2048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40775
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57647
OrthoDB	1	1.010	-	-		D376282at2759
OrthoFinder	1	1.000	-	-		FOG0005067
OrthoInspector	1	1.000	-	-		otm2901
orthoMCL	1	0.900	-	-		OOG6_102666
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.690