DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment l(3)72Dn and utp4

DIOPT Version :9

Sequence 1:	NP_001261930.1	Gene:	l(3)72Dn / 39774	FlyBaseID:	FBgn0263605	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	XP_005169982.1	Gene:	utp4 / 406571	ZFINID:	ZDB-GENE-040426-2466	Length:	703	Species:	Danio rerio

Alignment Length:	734	Identity:	181/734 - (24%)
Similarity:	339/734 - (46%)	Gaps:	79/734 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KEPQQR-----------GKHQVHNVRFYTIKPREIVSLAYSKSSKCLALSRATPVIELWNLEHAP 60
            |.|::|           |:.:||.|||:...|..|.:||:::.::.:|.::....:|:::.....
Zfish     3 KHPKERERKHTKRGSAMGEFKVHRVRFFEYVPSGIRALAFNQHNERMAAAKMNGSVEIFHCSDRF 67

  Fly    61 YLDRVIHLPTDSHVESIAWAGNRLFSVDLSGKLIEWDVIKLKQRYEHSPTGNALWSIDVNPAETD 125
            :.:::|.....:.:|.:.|.|.||||..|:|.:.|:|:...:.:|.....|..:|:|..|...|.
Zfish    68 FQEKIIPGREQAGIEGLTWVGERLFSAGLNGVITEYDLTNQRVKYTIDAYGGPIWAITGNQQGTH 132

  Fly   126 IAIGSEEGHINILSIENDEITYKSLFNKQKGRVLCIKFDKTGTKLVTGTEGFVRIWNVLKGTTLH 190
            :|:|.|:|.:.:..:..|:|.::...::||||::.:.:..:|:|:..|....::::||..|.:.|
Zfish   133 LAVGCEDGTVKLFEVTEDKIQFERNLDRQKGRIISLSWHPSGSKIAAGMMDMIQVFNVETGHSKH 197

  Fly   191 TM-------TLSEKNVIVWSLQVLSDNTIIAGDSAGFVTVWDADNATQIDSTRVLDKNVFALAVN 248
            .:       |...|..:|||:..|||.|||:|||.|.|.:|..|..|.|.|..:...:|.:|:|:
Zfish   198 RILVDRGYGTSRGKECVVWSVVYLSDGTIISGDSVGMVKMWRDDTGTLIKSHNITKSDVLSLSVS 262

  Fly   249 NKEDRLVCSGMQPPLIRIFSKTKIKREESTSERWIKFLQRDAHKHYVKSLLVIDDQIYSGGRDGI 313
            ..||.:|....:..:::....:.:.  |:..:.|::......|.|.|:::..|...:.|||.|..
Zfish   263 QNEDSIVAGTSEGFVVQFQFLSMVL--ENNEKDWVRTRTFRNHTHDVRAVAEITTAVVSGGMDTQ 325

  Fly   314 LTI----------TSSERMQAHLSQHAPFLKGSVASMAISKKLLLLRYPNSVHLWRLGSVAPQGE 368
            |.:          :|:.:::.....|.     |:.|.|.....||.:||..:.|||||....:|
Zfish   326 LVVRPLLDKHEVKSSASKLRKIQFPHR-----SLVSCARKAGTLLFQYPGHLELWRLGESEGEG- 384

  Fly   369 DKKKPWALPVGHTEEQLLELPPQKLLQLNVKEHNFIQSAAISSDANWICYSTLKELRISRLKSDP 433
                   :|   ....||:..|:|||.|.||..:.|:.:|:|....||.|||...||:.:|..|.
Zfish   385 -------IP---GSSLLLKRKPEKLLHLKVKGEDHIRCSAVSPCGEWIAYSTTSSLRLYKLHCDS 439

  Fly   434 LQVE-RLVDDLPEELQPASHIIFTKQGDLVLLNPQNNHLSWFTLEEDLVTFKYTIDLSEKCKNTI 497
            ..|. ..:..||:.|..||.:.|:.....:......:.:...:|.:....|..|..........|
Zfish   440 NNVSITKISKLPKVLGSASQLCFSSDSTHLFSASTQSSVHMVSLSQPECKFVATFKTKSGSHQAI 504

  Fly   498 SHVVISSHGEYIVAASSDHIISVWKLHGKQYKHLLNLPRHRAGTTALSMHEDYPRVVVAYANGQL 562
            ..:..|..|:::.:|:.|:.:.::.|..:  |....:|.:.:..:|:::|.....:.:.:|:.|:
Zfish   505 HLLAASEDGKWLASANIDNEVHIYNLQTR--KAHCTVPIYSSAVSAMAIHPTTNCLFMVHADQQI 567

  Fly   563 VEYDLVNRIFTCETNEY-----LIPETRRH---------CINGISLDPQNRNIFIVHTEGNLYVL 613
            .|       |:.|..||     |:.....|         |:| ::.:.:|.:..|:|......::
Zfish   568 FE-------FSIEQKEYTDWSRLVQRQGLHRIWLERDTPCLN-VTFNQKNPSHVILHDMYMFCII 624

  Fly   614 ERDQHLDPKELVSNSKSKKLSNGN-RSSVDGGSKGLSLKTTLSRQVRLHLVHVSRLSPNELVNVS 677
            ::.|.|      .:|||:.|:... ||..:...|..|....:.:..: .|:.|..:....||.|.
Zfish   625 DQSQPL------PDSKSQFLNQLTLRSLPEEQRKSYSHAFKVCKTFK-ELLCVDVMGDQSLVVVE 682

  Fly   678 ISTNNLLAPLPPPYQRKKF 696
            ....::.|.||.|.::|||
Zfish   683 RPLEDITAQLPAPIKQKKF 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Dn	NP_001261930.1	WD40	20..268	CDD:295369	71/254 (28%)
		WD40	57..529	CDD:225201	126/489 (26%)
		WD40 repeat	74..106	CDD:293791	11/31 (35%)
		WD40 repeat	115..151	CDD:293791	10/35 (29%)
		WD40 repeat	158..193	CDD:293791	7/41 (17%)
		WD40 repeat	283..331	CDD:293791	11/57 (19%)
		WD40 repeat	453..489	CDD:293791	4/35 (11%)
		WD40	<494..>603	CDD:295369	22/122 (18%)
		WD40 repeat	498..536	CDD:293791	6/37 (16%)
utp4	XP_005169982.1	WD40	34..323	CDD:295369	77/290 (27%)
		WD40	<35..277	CDD:225201	67/241 (28%)
		WD40 repeat	39..75	CDD:293791	5/35 (14%)
		WD40 repeat	82..116	CDD:293791	12/33 (36%)
		WD40 repeat	121..159	CDD:293791	10/37 (27%)
		WD40 repeat	166..208	CDD:293791	7/41 (17%)
		WD40	188..>559	CDD:225201	99/390 (25%)
		WD40	205..567	CDD:295369	96/381 (25%)
		WD40 repeat	215..246	CDD:293791	17/30 (57%)
		WD40 repeat	256..301	CDD:293791	8/46 (17%)
		WD40 repeat	307..348	CDD:293791	8/40 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593120
Domainoid	1	1.000	144	1.000	Domainoid score	I4582
eggNOG	1	0.900	-	-		E1_KOG2048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40775
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3324
OMA	1	1.010	-	-		QHG57647
OrthoDB	1	1.010	-	-		D237498at33208
OrthoFinder	1	1.000	-	-		FOG0005067
OrthoInspector	1	1.000	-	-		oto40166
orthoMCL	1	0.900	-	-		OOG6_102666
Panther	1	1.100	-	-	LDO	PTHR44163
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1621
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800