DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and ELG1

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_014787.3	Gene:	ELG1 / 854315	SGDID:	S000005670	Length:	791	Species:	Saccharomyces cerevisiae

Alignment Length:	774	Identity:	146/774 - (18%)
Similarity:	255/774 - (32%)	Gaps:	270/774 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 RRISSMDAQNQIVESKPPVVKAKDQDPGTEELLSKLSSPTKKRD--SLLGYFPKVESPKELAEKV 339
            |::...||....::.:      .|.:.||      ..:.|.|.|  |::.....|..|.|
Yeast    16 RKVRRQDALQITIDDE------NDTESGT------FDARTAKHDDSSVIFLNHSVVKPIE----- 63

  Fly   340 IIAIETPPMETPK----RRTLRRKSQQETPIVAESTPSSRPRRSCVGKARYDYDLETSPGKQQKA 400
              |:.|......:    :||..:....:..::..|..|.:...:|                .:.|
Yeast    64 --AVSTNHKSAKEFLMTKRTKEKCDDDDDDLIVISDKSPKSETNC----------------SKIA 110

  Fly   401 KPQKADESVEIIDLDNSNPAATPKKLAPLFVRQLPKPSPDPSVLKARQAFLQSGVPDKIRQEQIR 465
            ..|:.::.:.||                             |..:.:.:.|..      |..:|
Yeast   111 LSQEHEDDISII-----------------------------STSRIKSSLLNE------RASKI- 139

  Fly   466 QKNFDQMYEDSYEVFPRLAHIGCESFGSKNGPLDIPFALRAEEEYSEVTKALPANKRRAKASSIT 530
             |||  :..::.:.|.||..|      ||...::.|..|.        ....|...:.....|:.
Yeast   140 -KNF--LKHETTDTFKRLNSI------SKLNEIEPPLPLH--------QSIFPVGDKELSDRSVD 187

  Fly   531 SCLPADFTSSKTLNKFNYATLPQLENKRGFVKLWKNDFDRFPTFKCYNQMREKYRHFSAIDSAQD 595
            ..||     .:|:...|:..||             :|         |..:::|.   ||  |...
Yeast   188 IPLP-----FRTIPPLNHNFLP-------------SD---------YESLKDKN---SA--SCIP 220

  Fly   596 TQQMGESLVVTRRTRRSMEQNMAQNEEEAKPPPSAPNGELLFTEKYKPLLFEQVLVNLTPVQELR 660
            .:.....|:.|...|                     |..|.:.:.:||:..:|||:.  |..:||
Yeast   221 VRYQAPVLLGTNIKR---------------------NTTLTWPQLFKPVTLKQVLIE--PKLKLR 262

  Fly   661 EFLSSW------------SGNGGSNR----NSQGMDDTF------DMSND-------------SA 690
              :.:|            ..|...||    ..||..|..      |:..|             ::
Yeast   263 --IKNWIETSFHTLEKPTLRNRLLNRINPNKQQGSGDELANFIVPDLEEDENLRPDFYRNGEANS 325

  Fly   691 SMGSSSNTMVLVGPSSSGKTNAVFTL-----ANDMNFNVLEINAGMKRTGKKLIQELQEATQSHQ 750
            |:......|:|.| :|.||...:.|:     .:|.::.:.|:|:.|.|:.|.|:..|.:.|.:|.
Yeast   326 SLSEFVPLMILHG-NSIGKKTLIQTIMREIAGDDNSYQIYEVNSNMNRSKKDLLDILLDFTTTHY 389

  Fly   751 IRKDGKAGGGSSQQLLQKLQKSGLKAKAAAVEPPSEVRKS---LILIEDADILFDNLDAGFTDAI 812
            ::...|                               |||   |:|..|.|:||...|.|:...|
Yeast   390 VKDSSK-------------------------------RKSDYGLVLFNDVDVLFKEHDRGYWAMI 423

  Fly   813 YTLAASSKRPVIVVATDPNCAHLQRLM----QQNIIHFQAPNALNISRFLAVLSLMENCPIEL-- 871
            ..|...|:||:::...|.:....:.:.    |.::.|.:..:...:..||.  ..:::..||:
Yeast   424 SKLCEFSRRPLVLTCKDLSLVPSELIALASEQNSLFHTKKISTSTVYAFLT--KYLKSLEIEVCD 486

  Fly   872 DELISVYLYNQQNLRKTLMELQFYIQSGGDSTRDRTGGGIKSPTKTSN--------SRL------ 922
            |.|..|...|..::||.||.|||:..   |:..|......:.|..||.        |:|
Yeast   487 DWLRDVVKQNNADIRKCLMHLQFWCV---DTEADLISSKNRLPVLTSTLGSSVKDISQLTDLLSI 548

  Fly   923 ------ATVDGSRIHQRFFEFFTSPQNV------------QYRIPFPVDFSLLRLNLPD 963
                  ||::.|.:.|.......:|:.|            :.:..:.:|:. |.||.|:
Yeast   549 NDVIGQATLNRSMVRQEIDSTTMTPEKVNTFQDQNLDDEMKLKFDYVIDYK-LHLNDPN 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	34/136 (25%)
ELG1	NP_014787.3	PRK04195	335..>508	CDD:235250	48/206 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004592
OrthoInspector	1	1.000	-	-		oto99822
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R386
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030