DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and RFC1

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_680188.1	Gene:	RFC1 / 832261	AraportID:	AT5G22010	Length:	956	Species:	Arabidopsis thaliana

Alignment Length:	1085	Identity:	208/1085 - (19%)
Similarity:	363/1085 - (33%)	Gaps:	378/1085 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 IMKHFAKAGKPENVGVSPVST-AKPKPTTNVFEFMMNARNRSLGVNEGGAESPADQEIGSEAATP 201
            |.|.|.||.:..| |.:|.|| :|..|..|..|                 .:|...|..||....
plant     4 IRKWFMKAHEKGN-GSAPKSTSSKAGPVKNAAE-----------------TAPIKSEQASEDLET 50

  Fly   202 TTKRKLLLQEWNERKGGAKRRLADEARGEFIELQMEQRAKRLRKMLTKTDAKEVTAPSSAPTDPT 266
            ..:||.     ::..|..|.::.||...|.|..:        ||:.|:             :|..
plant    51 ADRRKT-----SKYFGKDKTKVKDEKEVEAIPAK--------RKLKTE-------------SDDL 89

  Fly   267 VKRLRGRPRSRRISSMDAQNQIVESKPPVVKAKDQDPGTEELLSKLSSPTKKRDSLLGYFPKVES 331
            ||     ||.|:::      ::|:         |.|...:..:|:     |.||:......|..|
plant    90 VK-----PRPRKVT------KVVD---------DDDDDFDVPISR-----KTRDTTPSKKLKSGS 129

  Fly   332 PKELAEKVIIAIETPPMETPKRRTLRRKSQQETPIVAESTPSSR-----PRRSCVGKARYDYDLE 391
            .:.:|.|.:...:....|           .:|||:  :|....|     |..|..|:.|
plant   130 GRGIASKTVDNDDDDDGE-----------DKETPL--KSAGRGRGGRAAPGASTGGRGR------ 175

  Fly   392 TSPGK-------QQKAKPQKADESVEIIDLDNSNPAATPKKLAPLFVRQLPKPSPDPSVLKARQA 449
             ..|:       ::|..|.|.::.|         |..||..||.|                   .
plant   176 -GGGRGGFMNFGERKDPPHKGEKEV---------PEGTPDCLAGL-------------------T 211

  Fly   450 FLQSGVPDKIRQEQIRQKNFDQMYED---------SYEVFPRLAHIGCE---------------- 489
            |:.||..|.:.:|:.         ||         :..|..:..::.|:
plant   212 FVISGTLDSLEREEA---------EDLIKRHGGRITGSVSKKTTYLLCDEDIGGRKSEKAKELGT 267

  Fly   490 SFGSKNGPLDIPFALRAEEEYSEVTKALP--ANKRRAKASSITSCLPADFTSSKTLNKFNYATLP 552
            .|.:::|..||   :|:.:   .|.|:||  :||...|.     |.|.             .|.|
plant   268 KFLTEDGLFDI---IRSSK---PVKKSLPERSNKGTEKI-----CAPP-------------KTSP 308

  Fly   553 QLENKRGFVKLWKNDFDRFPTFKCYNQMREKYRHFSAIDSAQDTQQMGESLVVTRRTRRSMEQNM 617
            |.|..||                                                       :.:
plant   309 QKEETRG-------------------------------------------------------KPL 318

  Fly   618 AQNEEEAKPPPSAPN----GELLFTEKYKPLLFEQVLVNLTPVQELREFLSSWS---GNGGSNRN 675
            |::..:..||....|    ..|.:||||:|.:..:::.|.:.|.:|..:||.|.   |..||...
plant   319 AKSSPKKVPPAKGKNKIIETSLPWTEKYRPKVPNEIVGNQSLVTQLHNWLSHWHDQFGGTGSKGK 383

  Fly   676 SQGMDDTFDMSNDSASMGSSSNTMVLVGPSSSGKTNAVFTLANDMNFNVLEINAGMKRTGKKLIQ 740
            .:.::|           ..|...::|.|....|||.:...::..:.|..:|:||...|
plant   384 GKKLND-----------AGSKKAVLLSGTPGIGKTTSAKLVSQMLGFQAVEVNASDSR------- 430

  Fly   741 ELQEATQSHQIRKDGKAG-------GGSSQQLLQKLQKSGLKAKAAAVEPPSEVRKSLILIEDAD 798
                          |||.       |||:...:::|..:  :|.||..:.....:..||:.|
plant   431 --------------GKANSNIAKGIGGSNANSVKELVNN--EAMAANFDRSKHPKTVLIMDE--- 476

  Fly   799 ILFDNLDAGFTDAIYTLAAS---SKRPVIVVATDPNCAHLQRLMQQNI-IHFQAPNALNISRFLA 859
              .|.:.||....:..|.||   ||.|:|.:..|.....|:.|:...: ::::.|....:::.|.
plant   477 --VDGMSAGDRGGVADLIASIKISKIPIICICNDRYSQKLKSLVNYCLPLNYRKPTKQQMAKRLM 539

  Fly   860 VLSLMENCPIELDELISVYLYNQQN--LRKTLMELQFYIQSGG----DSTRDRTGGGIK----SP 914
            .::..|.  :|::|:....|..:.|  :|..:.:||:...|..    |..|.|.....|    ||
plant   540 HIAKAEG--LEINEIALEELAERVNGDIRLAVNQLQYMSLSMSVIKYDDIRQRLLSSAKDEDISP 602

  Fly   915 TKTSNSRLATVDGSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLPDLMASSAMLKEQQAAGG 979
            . |:..:|...:|.::                |:...:|.|:...:|..|:.....|..:.:
plant   603 F-TAVDKLFGYNGGKL----------------RMDERIDLSMSDPDLVPLLIQENYLNYRPS--- 647

  Fly   980 GSRTAAKRKSRSPKKAWLSSATGQKSDGHSSSLATLASFYDNISVASLMDSDCSDRLQWHLSEE- 1043
             .:..|||                        :..||...::|:...:::.......||.||:.
plant   648 -GKDEAKR------------------------MDLLARAAESIADGDIINVQIRRYRQWQLSQSC 687

  Fly  1044 -IGHLLVEQALQTG----LATKECPYNLFDKPVQRFS-------ICQHLGNGVLRSDSAKS---- 1092
             :...::..:|..|    |...|..:|.|...:.:.|       :.:.|...||.|..:.:
plant   688 CVASSILPASLLHGSREVLEQGERNFNRFGGWLGKNSTAGKNRRLMEDLHVHVLASRESSAGRET 752

  Fly  1093 --LDFEPALRSICRSEKERAGLERKSSRFYHYLRNHTVNVTSFTT 1135
              :|:.|.|.|...|..:....:...|....::.:::::...|.|
plant   753 LRVDYLPLLLSRLTSPLQTLPKDEAVSEVVDFMNSYSISQEDFDT 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	33/138 (24%)
RFC1	NP_680188.1	COG5275	40..319	CDD:227600	81/465 (17%)
		BRCT	209..280	CDD:237994	14/101 (14%)
		PRK04195	340..>683	CDD:235250	87/428 (20%)
		P-loop_NTPase	396..>487	CDD:304359	26/118 (22%)
		RFC1	665..827	CDD:285691	24/133 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23389
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000