Protein Alignment elg1 and ATAD5

DIOPT Version :9

• Sequence 1: NP_996103.1
• Gene: elg1 / 39770
• FlyBaseID: FBgn0036574
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_011523571.1
• Gene: ATAD5 / 79915
• HGNCID: 25752
• Length: 1845
• Species: Homo sapiens
• Alignment Length: 1561
• Identity: 320/1561 - (20%)
• Similarity: 560/1561 - (35%)
• Gaps: 530/1561 - (33%)

  Fly    45 PPSAKSKL----ILQNMEEVLNSVKQKHREKHKRKR-------EEKRRAALMEDQKSTTEEVKAN 98
            ||....|:    :.|...|:.||:.....|:..:||       ||:...|::|...|...:.|..
Human   332 PPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCT 396

  Fly    99 AKEKPQPLRE-KSSQENGLKNGRRRSSPLKSSTPVADNQSIM--KHFAKAGKP-------ENVGV 153
            .:|:.|.::. :....:.||||.::||         |.|..:  |...:.|:.       ||.|:
Human   397 LEERQQFMKAFRQPASDALKNGVKKSS---------DKQKDLNEKCLYEVGRDDNSKKIMENSGI 452

  Fly   154 SPVS-TAKPKPTTNVFEFMMNARNRSLGVNEGGAESPADQEIGSEAATPTTKRKLLLQE--WNER 215
            ..|| ....:..|:...|:.....:....|:...::.|......|..|...:....|:|  :..|
Human   453 QMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNR 517

  Fly   216 KGGAKRR----------------LADEARGEFIELQMEQRAKRLRK---------MLTKTDAK-- 253
            ....:|:                ..|.|..:.:::.......:|.:         .||::.|:
Human   518 MSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESE 582

  Fly   254 ----EVTAPSSA------PTDPTVKRLRGRPRSRRISSMDAQNQIVESKPPVVKAKDQDPG---- 304
                .|:.|.|.      .:.||.:.:||      |.|.|.|:.      ..:||..|...
Human   583 ASLLNVSTPKSTRRSGRISSTPTTETIRG------IDSDDVQDN------SQLKASTQKAANLSE 635

  Fly   305 -----TEELL--------------SKLSSPTK----------KRDSLLGYF-----------PKV 329
                 |.||:              :::|:|.|          |.::..|.|           ..:
Human   636 KHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNI 700

  Fly   330 ESPKELAE----------KVIIAIETPPMETPKRRTL-RRKSQQETP---IVAESTPSS--RPRR 378
            ...|:|.|          ||...|..|...:.:.:|| .||...||.   |:.:|:|::  .|.:
Human   701 SKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEK 765

  Fly   379 S-----C----VGKARYDYDLETS----PGKQQKA------KPQKADESVEIIDLDNSNPAATPK 424
            :     |    :||     .|.||    |||.:.|      |.|||.:.|...|..:.:   |.:
Human   766 NQKKLQCLNDVLGK-----KLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQD---TSE 822

  Fly   425 KLAPLFVRQLPKPSPDPSV-LKARQAFLQSGVPDKIRQEQIRQKNFDQMYEDSYEVFPRLAHI-- 486
            |            |.|..| .||::.||.||:||.::::..::.....:|......|.|:.|:
Human   823 K------------SQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQ 875

  Fly   487 ---GCESFGSKNGPLDIPFALRAEEEYSEVTKALPANKRRAKASSITSCLPA------------D 536
               ||..:..|  |...|...:.:|..::|...........:.|::.|.|.:            :
Human   876 KDDGCCLWHLK--PPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKE 938

  Fly   537 FTS---SKTLNKFNYATLPQLENKRGFVKLWKNDFD-RFPTFKCYNQMRE----------KYRHF 587
            ||.   :..|.:..::. |:...|:.|..|.|...: :..:.:|:::..|          |.:..
Human   939 FTEEVRNLLLEEIRWSN-PEFSLKKYFPLLLKKQIEHQVLSSECHSKQAELEADVSHKETKRKLV 1002

  Fly   588 SAIDSAQDTQQMGE-SLVVTRRTRRSMEQNMAQNEEEAKPPPSAPNG--ELLFTEKYKPLLFEQV 649
            .|.:|....::..| |..:.:..|:|.|.:...|....|...|..:|  ::|:||||:|....::
Human  1003 EAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASEL 1067

  Fly   650 LVNLTPVQELREFLSSWSGNG--GSNRNSQGMDD----------TFDMSNDSASMGSSSNTMVLV 702
            :.|...:::|..:|..|....  ...:|.:|..|          .|..|:|........||:::.
Human  1068 IGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLIT 1132

  Fly   703 GPSSSGKTNAVFTLANDMNFNVLEINAGMKRTGKKLIQELQEATQSHQIRKDG------------ 755
            ||:..|||.||:..|.::.|.:.|:||..:|:|::::.:|:|||||||:.|.|
Human  1133 GPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSY 1197

  Fly   756 ---------------------------KAGG--------------------GSSQQLLQKLQKS- 772
                                       |:.|                    .:::::...|:.:
Human  1198 YIGKSPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNK 1262

  Fly   773 GLK--------------------AKAAAVEPPSEVRK---SLILIEDADILFDNLDAGFTDAIYT 814
            |:|                    .|....|.||  ||   ||||.|:.|::||. ||||.:||.|
Human  1263 GIKNSFEQKQITQTKSTNATNSNVKDVGAEEPS--RKNATSLILFEEVDVIFDE-DAGFLNAIKT 1324

  Fly   815 LAASSKRPVIVVATDPNCAHLQRLMQQNI---IHFQAPNALNISRFLAVLSLMENCPIELDELIS 876
            ..|::|||||:..:||..:    ||....   |.|..|:.||::.:|.::.|.||...::.:.::
Human  1325 FMATTKRPVILTTSDPTFS----LMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVT 1385

  Fly   877 VYLYNQQNLRKTLMELQFYIQSGGDSTRDR----------------TGGGIKSPTKTSNSRLATV 925
            :...|..::||:::.|||:|:|||....:|                :..|:.:.....|::...|
Human  1386 LLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIYPKNTKKKRV 1450

  Fly   926 DGSRI--------------------------HQ--------RFFEFFTSPQ---------NVQYR 947
            |..:.                          |:        :|.:..|..|         |:::.
Human  1451 DLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQMRNVDFLYSNLEFI 1515

  Fly   948 IPFPVDF------------------------SLLR------------------------------ 958
            :|.|||.                        .|.|
Human  1516 LPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLF 1580

  Fly   959 ---LNLPD----LMASSAMLKEQQAAGGGSRTAAKRKSRSP--KKAW---LSSATGQKSDG-HSS 1010
               |:.||    |.:.|:....:::..|...:.|:.|..:|  ||:.   ..:..|:|... .|.
Human  1581 DTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKGNNPETKKSIPCPPKTTAGKKCSALVSH 1645

  Fly  1011 SLATLASFYDNISVASLMDSDCSDR-------LQWHLSEEIGHLLVEQALQT------------- 1055
            .|.:|:.|.||:|....:.:|..::       ..|...:....|..|.:|::
Human  1646 CLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWTNGKVTSGLCDEFSLESNDGWTSQSSGELK 1710

  Fly  1056 ----GLATKECPYNLFDKPVQRFSICQHLG---------------NGVLRSDSAKSLD------- 1094
                .|:..:|. :...|.::..:.|:.||               |.|..|.||.:||
Human  1711 AAAEALSFTKCS-SAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANLDNAWKRIS 1774

  Fly  1095 -----------------------FEPALRSICRSEK-ERAGLERKSSRFYHY-------LRNHTV 1128
                                   :.|.||:||::|| :..|..::  ||.||       :...||
Human  1775 VIKSVFSSRSLLYVGNRQASIIEYLPTLRNICKTEKLKEQGKSKR--RFLHYFEGIHLDIPKETV 1837

  Fly  1129 N 1129
            |
Human  1838 N 1838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376	20/79 (25%)
		P-loop_NTPase	699..828	CDD:304359	56/211 (27%)
ATAD5	XP_011523571.1	P-loop_NTPase	1129..>1174	CDD:304359	15/44 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148260
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3900
Isobase	1	0.950	-	0	Normalized mean entropy	S7521
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004592
OrthoInspector	1	1.000	-	-		oto90445
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R386
SonicParanoid	1	1.000	-	-		X5719
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.920