DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and Atad5

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_220750.6	Gene:	Atad5 / 303348	RGDID:	1561464	Length:	1834	Species:	Rattus norvegicus

Alignment Length:	1602	Identity:	318/1602 - (19%)
Similarity:	556/1602 - (34%)	Gaps:	564/1602 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NCLTSEHIAPTTTTASPPGTPSKNAATDPVEPTSPFVLRAPPSAKSKL----ILQNMEEVLNSVK 65
            :|..|.|:...|.|           ....|.||       ||..|.|:    :.|...|:.||..
  Rat   316 SCEPSPHLHLKTVT-----------VLAQVHPT-------PPKKKRKIPPIFLKQKQLELENSFS 362

  Fly    66 QKHREKHKRKR-------EEKRRAALMEDQKSTTEEVKANAKEKPQPLRE-KSSQENGLKNGRRR 122
            ....|:..:||       |.:...|::|...|.....|.:.:|:.|.:|. :......|:||.::
  Rat   363 DPENEQTVQKRKSNVVVQEGQLELAVLEAWSSEASVPKCSMEERQQFMRAFRQPPSETLRNGLKK 427

  Fly   123 SSPLK---------------SSTPVADNQSIMK---------HFAKAGKPENVGVSPVSTAKPKP 163
              ||:               :|..:.:|.:|.:         |..:.|.|:.....|....|...
  Rat   428 --PLEKQKDPSEKSVNEGDSNSEKIIENPNIQRVSNQDCSQAHADRGGFPKEKSKRPNKKGKKTR 490

  Fly   164 TT---NVFEFM--------------MNARNRSL----GVNEGGAESPADQEIGSEAATPTTKRKL 207
            ||   |..|.|              .|...||:    .|.:..|...::..:..:.|..:.|..|
  Rat   491 TTAAGNREENMQKEKTAFSLKDNQDQNTLRRSVRQKSEVFKSSALLNSENLVSEDTARDSVKPSL 555

  Fly   208 LLQEWNERKGGAKRRLADEARGE----FIELQMEQRAKR-LRKMLTKT----------DAKEVTA 257
            ..:..:.|.....|.:....:.|    .:.:...:..:| ||...|.|          ||:: |.
  Rat   556 CDRNKSRRGSTPTRDMVTHGKAEPGSGLVNVSTPKPTRRSLRGSSTPTTVTLGGTESEDAQD-TD 619

  Fly   258 PSSAPTDPTVKRLRGRPRSRRISSMDAQNQIV--ESKPPV----------VKAKDQDPGTEELLS 310
            |..|.| |...|:..:|     |...|:..|:  :|:.|:          .|:|.....:|....
  Rat   620 PVKAST-PKAARISEKP-----SLYTAELIIISSDSESPIRMKFTRISTPKKSKKSSKKSERTKE 678

  Fly   311 KLSSPTKKRDSLLGYFPKVESPKELAEKV----IIAIETPPMETPKRRTLRRKSQQETPIVAEST 371
            :|:|...|.::.   ..|:...|:|.|:.    :...:......|    |||.|:.:|.:..|.:
  Rat   679 ELTSQKNKANNT---SKKISKAKQLIERAKAFQVSGSKAEETVVP----LRRSSRHQTRLEREKS 736

  Fly   372 PSSRPRRSCVGKARYDYD-----LETSPGK-QQKAKPQKADESVEII---DLDNSNPAATPK-KL 426
            |.:              |     ::::|.. :|..|.||..:::..:   .|:.|:.....| |:
  Rat   737 PET--------------DDSVILIDSNPTSIRQPEKNQKKLQNLNDVLGKKLNKSSKKVPGKMKI 787

  Fly   427 APLFVRQ-----------LPKPSPDPS--------VLKARQAFLQSGVPDKIRQEQIRQKNFDQM 472
            ||||:.:           |.:.|.|.|        ..||::.||.||:||.::::..::.....:
  Rat   788 APLFLTKKTKRTAISAFDLDESSQDSSGQTQDCDVQFKAKRDFLMSGLPDLLKRQIAKRAAALDV 852

  Fly   473 YEDSYEVFPRLAHIGCESFGSKNG--------PLDIPFALRAEEEYSEVTKALPANKRRAKASSI 529
            |......|.|:.|:     ..|:.        |...|..    .|:.|:         ..|.:.:
  Rat   853 YNAVSTSFQRVVHV-----QQKDDEYWLWHLKPPSCPLL----TEFKEL---------NTKVTDL 899

  Fly   530 TSCLPADFTSSKTLN---KFNYATLPQLENKRGFVK----------LWKN-DFDRFPTFKCYNQM 580
            :.||.| |....|||   :.|.|.: .:..::.|.|          .|.| :|.....|....:.
  Rat   900 SKCLVA-FGEFSTLNPNPRSNPAVV-LMRTRKEFTKEVRNLLLEEIKWSNPEFSLGKYFPLLLKK 962

  Fly   581 REKYRHFSAIDSAQDTQQMGESLVVTRRTRRSMEQNMAQNEEEAKP------------------- 626
            |.:::........|.:.|: :..|..:.|:|...:..:|..:..||
  Rat   963 RIEHQVLCEGHGKQASPQL-QPDVSQKETKRKQVETGSQKSKRKKPNEYSVSPEKIKGKSKELDK 1026

  Fly   627 ---------PPSAPNG--ELLFTEKYKPLLFEQVLVNLTPVQELREFLSSWSGNG--GSNRNSQG 678
                     .||..:|  ::|:||||:|....:::.|...:::|..:|..|....  ...:|.:|
  Rat  1027 RISSSCINLDPSKESGTEDMLWTEKYQPQNSNELVGNELAIKKLHSWLKDWKRRAELEERQNLKG 1091

  Fly   679 MDD--TFDMSNDSASMGSSS-------NTMVLVGPSSSGKTNAVFTLANDMNFNVLEINAGMKRT 734
            ..|  ..|:|:.:...|||.       ||:::.||:..|||.||:..|.::.|.:.|:||..:|:
  Rat  1092 KRDEKEEDLSDGTDFKGSSDDEEYRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRS 1156

  Fly   735 GKKLIQELQEATQSHQIRKDGKAG--------------------------------------GGS 761
            |::::.:|:|||||||:.|.|...                                      ||.
  Rat  1157 GRQILSQLREATQSHQVDKQGANSQKPCFFSNYNIGKSPKKLNSPGKVITSPRKLPPLSPKTGGQ 1221

  Fly   762 SQQLLQKL---------------------------------QKSGLKAKA-----------AAVE 782
            .:.||.|.                                 |:..::.|:           .|.|
  Rat  1222 KRALLPKTLANYFKVSSKSNNNEDVGARPGNDKGVKNSSLEQRQIIQTKSTNANNSNIKDFGAEE 1286

  Fly   783 PPSEVRKSLILIEDADILFDNLDAGFTDAIYTLAASSKRPVIVVATDP-------NCAHLQRLMQ 840
            ...:...||||.|:.|::||. ||||.:|:.|..|::|||||:..:||       .|.
  Rat  1287 SNRKNATSLILFEEVDVIFDE-DAGFLNAVKTFMATTKRPVILTTSDPTFSLVFDGCF------- 1343

  Fly   841 QNIIHFQAPNALNISRFLAVLSLMENCPIELDELISVYLYNQQNLRKTLMELQFYIQSGGDSTRD 905
             ..|:|..|:.||::.:|.|:.|:||...:..:.:::...|..::||:::.|||:|:|||....:
  Rat  1344 -EEINFNIPSLLNVASYLQVICLVENFRTDFKDFVTLLTANACDIRKSILYLQFWIRSGGGILEE 1407

  Fly   906 R----------------------------------------TG-----GGIKSPTKTSNSRLATV 925
            |                                        ||     .|:|:....|...|:::
  Rat  1408 RPLSHCRENSRNTLVCSEHESDANINSKNTKRNRVALPRCDTGCAEALFGLKNIACPSQDLLSSL 1472

  Fly   926 --------DGSRIHQRFFEFFTS-----PQNVQYRIPFPVDFSLLRLNLPDLM------------ 965
                    :..|:.|...||...     ..|:::.:|.||:.      :|::.
  Rat  1473 KHKITTKEEWQRLIQLLTEFHMQNVDLLHSNLEFILPLPVNM------IPEVRGAYGFPVTTQAS 1531

  Fly   966 --ASSAMLKEQQAAGGGSRTAAKRKSR-----------------SPKKAWLSSATGQKSDGHSS- 1010
              ||..:|..:|:.....|.:.|||.:                 |.:...||.|.....:.::|
  Rat  1532 APASMKLLNRKQSEDQPLRKSQKRKQKKMVTLDDSDLFDTSLDFSGELPSLSPAASSSEEDNTSR 1596

  Fly  1011 --------------------------------------SLATLASFYDNISVASLMDSD------ 1031
                                                  .|.:|:.|.:|:|....:.:|
  Rat  1597 DRGSNPEIKTQNKGFKPHSLPQPPKTLAEKKCCVLVSHCLNSLSEFMENMSFVDALFTDPGEQNE 1661

  Fly  1032 -----------------CSD-----RLQW--HLSEEIGHLLVEQALQTGLATKECPYNLFDKPVQ 1072
                             |.:     |..|  ..|||:      :|....|:..:|. :...|.::
  Rat  1662 LGKSAFHWTNGKVKSGLCDEFSLENRDGWSPRSSEEL------KATAEALSFTKCS-STISKALE 1719

  Fly  1073 RFSICQHLGN---------------------------------GVLRS------------DSAKS 1092
            ..:.|:.||.                                 .|::|            ..|..
  Rat  1720 SLNSCKQLGRDPTTELTFCVSQRSHDVCFRQSAANLYNADKRMAVIKSVFSTPSFLTLGNKQASI 1784

  Fly  1093 LDFEPALRSICRSEKERAGLERKSSRFYHYLRNHTVNVTSFT 1134
            :|:.|.||:|||:||.:. .|:...||.||.....:::...|
  Rat  1785 IDYLPTLRNICRTEKLKE-QEKNKRRFLHYFEGIHLDIPEET 1825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376	19/94 (20%)
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	53/210 (25%)
Atad5	XP_220750.6	P-loop_NTPase	1121..>1166	CDD:304359	15/44 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I3626
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004592
OrthoInspector	1	1.000	-	-		oto97556
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23389
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5719
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.940