DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and elg1

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_595265.1	Gene:	elg1 / 2541276	PomBaseID:	SPBC947.11c	Length:	920	Species:	Schizosaccharomyces pombe

Alignment Length:	975	Identity:	192/975 - (19%)
Similarity:	342/975 - (35%)	Gaps:	286/975 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 ELQMEQRAKRLRKMLTKTDAKEVTA----------PSSAPTDPTVKRLRGRPRS--RRISSMD-A 284
            :|:.|..||..:.:..:.....|.|          |.|....|...|...:.||  |:...|| .
pombe    16 DLKSENEAKEEKPIGRRHTMSPVPATSENKYFGKSPLSGSRKPRRSRSLHKERSYMRKFFDMDME 80

  Fly   285 QNQIVESKPPVVKAKDQDPGTEELLSKLSSPTKKRDSLLGYFPKVESPKELAEKVIIAIETPPME 349
            :::..|:...::..........:.:..:..|....|:....||..:|..|.::..|:.......|
pombe    81 ESKDFENDQSLLVTLKVSTSLGQKIENILHPKLSNDTNSTAFPPAKSSGEASDTNILVENINSQE 145

  Fly   350 TPKRRTLRRKSQQETPIVAE-------STPSSRPRRSCVGKARYDYDLETSPGKQQKAKPQKADE 407
            |          ...:|:|:|       .:||:  .|:.|          ||......:|..|.:.
pombe   146 T----------VNSSPLVSELHYSNLADSPSN--LRNTV----------TSMHPFFMSKSVKKNS 188

  Fly   408 SVEIIDLDNSNPAATPKKLA-PLFVRQLPKPSPDPSVLKARQAFLQSGV---PDKIRQEQIRQKN 468
            .::.:..:..  ...|::|. ||:      |:||...:......::..|   |.|..:|.|
pombe   189 EIKFVSEERG--GTKPERLLDPLW------PTPDSQSMLEYAGSIEPSVFWFPKKHLEEAI---- 241

  Fly   469 FDQMYEDSYEVFPRLAHIGCESFGSKNGPLDIPFALRAEEEYSEVTKALPANKRRAKASSITSCL 533
               :.|.|:..|.       |...|....:..|.   ||:..:||.:..|:........|:  |.
pombe   242 ---LEETSHLSFK-------EVLSSTTANMITPL---AEKNKTEVLQVTPSKLHTFALESL--CF 291

  Fly   534 -PADFTSSKTLNKF-------NYATLPQLENKRGFVKLWKNDFDRFPTFKC--YNQMREKYRHFS 588
             ||.|. .|.|::.       ....:||:..|    .||.:.:....|..|  ::|...|...:
pombe   292 SPAPFI-QKVLSRLLPSDPNVEMPMIPQILEK----GLWVSKYAPSKTQDCCAFSQCLSKIADW- 350

  Fly   589 AIDSAQDTQQMGESLVVTRRTRRSMEQNMAQNEEEAKPPPSAPNGELLFTEKYKPLLFEQVLVNL 653
             :.|.:.|:....|:..:....||...:...:        |..|.:.|....::|.:.|:
pombe   351 -LRSCRLTKPESSSVPPSSSISRSSTIHSCTS--------SKRNEDSLSESDFEPDIIEE----- 401

  Fly   654 TPVQELREFLSSWSGNGGSNRNSQGMDDTFD--MSNDSASMGSS--SNTMVLVGPSSSGKTNAVF 714
                                   :...|.|:  :|...|.:.||  ||.|::.|.:..|||:.::
pombe   402 -----------------------EDDSDEFNPSVSRKKAKLTSSQFSNWMLVTGVTGIGKTSCLY 443

  Fly   715 TLANDMNFNVLEINAGMKRTGKKLIQELQEATQSHQIRKDGKAGGGSSQQLLQKLQKSGLKAKAA 779
            .:..::||.|:||:.||:|:||:|::.:.|.||||.:                  .||.|
pombe   444 AICRELNFEVVEIHPGMRRSGKELLERIGELTQSHIV------------------DKSRL----- 485

  Fly   780 AVEPPSEVRKSLILIEDADILFDNLDAGFTDAIYTLAASSKRPVIVVATDPNCAHLQRLMQQNII 844
                 :.....|||:|:.||||.: |.||..|:.||...|||||::...:.:......|.:.:|:
pombe   486 -----NNTPDILILLEEVDILFQD-DRGFWQAVSTLIEKSKRPVVMTCNETDFLPSAFLQEDHIV 544

  Fly   845 HFQAPNALNISRFLAVLSLMENCPIELDELISV-YLYNQQNLRKTLMELQFYIQSGGDSTRDRTG 908
            .||:.::..::.:::.:...:.|.|..:.:.|: |.|. .:||..||:|.|:
pombe   545 QFQSISSALLTDYISSVLYADRCIISRNVVESISYRYG-SDLRGILMQLNFW------------- 595

  Fly   909 GGIKSPTKTSNSRLATVDGSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLPDLMASSAMLKE 973
                                                          ||  :|.|.|
pombe   596 ----------------------------------------------SL--VNFPSL--------- 603

  Fly   974 QQAAGGGSRTAAKRKSRSPKKAWLSSATGQKSDGHSSSL-ATLASFYDNISVASLMDSDCSDRLQ 1037
                              |.|       .::.|.|...: ||:::|.:.:.|.:.......|.||
pombe   604 ------------------PSK-------DKQDDSHEPFIEATISAFDEGVGVYNPRIQTSEDLLQ 643

  Fly  1038 WHLSEEIGHLLVEQALQTGLA--------TKEC-PYNLFDKPVQRFSICQHLGNGVLRSDSAKSL 1093
            .:..|::|.:        ||.        .|.| |.:..:   ::.:|.:.|......:||...:
pombe   644 TYSEEQMGDI--------GLLFMPNLVNWRKVCVPKSEME---EKEAIMEKLIYSHQYADSLSYV 697

  Fly  1094 DF----EPALRSICRSEKERAGLERKSSRFYHYLRNHTVNVTSFTTDYFDTACSTFQSAAPSSEP 1154
            |:    :|.:........:.|..|..|..    .|::..|........|.|..:.|.:.|| .||
pombe   698 DYRFSSQPTIYETYELMNDSASFEDMSLE----CRDNCANAFQDNLVGFPTISNPFHANAP-PEP 757

Fly 1155 1154
pombe 758 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	43/128 (34%)
elg1	NP_595265.1	P-loop_NTPase	428..538	CDD:304359	30/113 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004592
OrthoInspector	1	1.000	-	-		oto101500
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R386
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.030