DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and rfc1

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_596607.1	Gene:	rfc1 / 2540426	PomBaseID:	SPBC23E6.07c	Length:	934	Species:	Schizosaccharomyces pombe

Alignment Length:	943	Identity:	191/943 - (20%)
Similarity:	319/943 - (33%)	Gaps:	293/943 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 PSSAPTDPTVKRLRGRPRSRRISSMDAQNQIVESKPPVVKAKDQDPG-TEELLSKLSSPTKKRDS 321
            |..:||..:.|..|...:.|.:.|.|....|..||.|..|:|.|... :|::...|.|...:.|.
pombe    19 PKVSPTPTSPKPKRSLKKKRIVLSDDEDGTIENSKVPASKSKVQKRNESEDISHSLPSIVHEDDK 83

  Fly   322 LLG----------YFPKVESPKELAEKVIIAIETP-------PMETPKRRTLRRKSQQETPIVAE 369
            |:|          ||.:..:......::|...||.       |::|.........:....|:|.:
pombe    84 LVGSDGVSTTPDEYFEQQSTRSRSKPRIISNKETTTSKDVVHPVKTENFANDLDTTSDSKPVVHQ 148

  Fly   370 STPSSRP-----RRSCVGKAR---YDYDLETSPGKQQKAKPQKADE------SVEIIDLDNSNPA 420
            :..:.:|     .:|...|::   ......||...:.|..|:.:||      :|.:||:|:....
pombe   149 TRATRKPAQPKAEKSTTSKSKSHTTTATTHTSRSSKSKGLPRFSDEVSQALKNVPLIDVDSMGVM 213

  Fly   421 ATPKKLAPLFVRQLPKPSPDP---SVLKARQAFLQSGVPDKIRQEQIRQKNFDQMYEDSYEVFPR 482
            |...........|.|...|.|   |...:..:|:.:|:.:.:    .||:..|.:.:...:|
pombe   214 APGTFYERAATTQTPGSKPVPEGNSDCLSGISFVITGILETL----TRQEATDLIKQYGGKV--- 271

  Fly   483 LAHIGCES-------FGSKNGPLDIPFALRAEEEYSEVTK--ALPANKRRAKASSITSCLPADFT 538
               .|..|       .|...||..:           |..|  .:||.........||. |||...
pombe   272 ---TGAPSVRTDFILLGENAGPRKV-----------ETIKQHKIPAINEDGLFYLITH-LPASGG 321

  Fly   539 SSKTLNKFNYATLPQLENKRGFVKLWKNDFDRFPTFKCYNQMREKYRHFSAIDSAQDTQQMGESL 603
            :.                                               :|..:||..::..|..
pombe   322 TG-----------------------------------------------AAAQAAQQKKEQEEKK 339

  Fly   604 VVTRRTRRSMEQNMAQNEEEAKPPPSAPNGELLFTEKYKPLLFEQVLVNLTPVQELREFLSSWSG 668
            ::  .|...|:.:   |::|::|       ..::|.||.|...:.:..|...||:|:::|..:..
pombe   340 IL--ETVARMDDS---NKKESQP-------SQIWTSKYAPTSLKDICGNKGVVQKLQKWLQDYHK 392

  Fly   669 NGGSNRNSQGMDDTFDMSNDSASMGSSSNTMVLVGPSSSGKTNAVFTLANDMNFNVLEINAGMKR 733
            |..||.|..|.|          .:| ....::|.||...|||.|...:|....::|||:||...|
pombe   393 NRKSNFNKPGPD----------GLG-LYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTR 446

  Fly   734 TGKKLIQELQEATQSHQIRKDGKAGGGSSQQLLQKLQKSGLKAKAAAVEPPSEVRKS-LILIEDA 797
            :.:.|.::|...|.|..:     ||            ..|.||.      |.::.|| |:||.|.
pombe   447 SKRLLDEQLFGVTDSQSL-----AG------------YFGTKAN------PVDMAKSRLVLIMDE 488

  Fly   798 DILFDNLDAGFTDAIYTLAASSKRPVIVVATD---PNCAHLQRLMQQNIIHFQAPNALNI-SRFL 858
            .....:.|.|....:..:...|..|:|.:..|   |....|.|....  :.|:.|:|.:: ||.:
pombe   489 IDGMSSGDRGGVGQLNMIIKKSMIPIICICNDRAHPKLRPLDRTTFD--LRFRRPDANSMRSRIM 551

  Fly   859 AV-----LSLMENCPIELDELISVYLYNQQNLRKTLMELQFYIQSGGDSTRDRTGGGIKSPTKTS 918
            ::     |.|   .|..:|:|:.   ..|.::|:.:..|..|                    |.|
pombe   552 SIAYREGLKL---SPQAVDQLVQ---GTQSDMRQIINLLSTY--------------------KLS 590

  Fly   919 NSRLATVDGSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLPDLMASSAMLKEQQAAGGGSRT 983
            .|.:                 :|||                       |.|::|..:
pombe   591 CSEM-----------------TPQN-----------------------SQAVIKNSE-------- 607

  Fly   984 AAKRKSRSPKKAW-LSSATGQKSDGHSSSLATLASFYDNISVASLMDSDCSDRLQWHLSE-EIGH 1046
                 .....|.| :.|........|.||.:|:                 :|:|:.:.:: |..:
pombe   608 -----KHIVMKPWDICSRYLHGGMFHPSSKSTI-----------------NDKLELYFNDHEFSY 650

  Fly  1047 LLV-EQALQTGLATKECPYNLFDKPVQRFSICQHL------GNGVLRSDSAKSLDFEP------- 1097
            |:| |..|.|      .|..:..:| .:.|..:||      .|....||...|:...|
pombe   651 LMVQENYLNT------TPDRIRQEP-PKMSHLKHLELISSAANSFSDSDLVDSMIHGPQQHWSLM 708

  Fly  1098 ---ALRSICRSEKERAGLERKSSRFYHYLRNHT 1127
               ||.|..|.....||...:..||.::|.|::
pombe   709 PTHALMSCVRPASFVAGSGSRQIRFTNWLGNNS 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	35/129 (27%)
rfc1	NP_596607.1	COG5275	78..360	CDD:227600	60/362 (17%)
		BRCT	243..313	CDD:237994	15/90 (17%)
		AAA	409..539	CDD:99707	39/154 (25%)
		AAA	412..542	CDD:214640	40/154 (26%)
		HolB	506..>590	CDD:223546	22/111 (20%)
		SAGA-Tad1	<541..581	CDD:289533	11/45 (24%)
		RFC1	689..843	CDD:285691	14/53 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000