DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and Y53F4B.9

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_497095.1	Gene:	Y53F4B.9 / 175155	WormBaseID:	WBGene00013156	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	1083	Identity:	213/1083 - (19%)
Similarity:	355/1083 - (32%)	Gaps:	349/1083 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DVNCLTSEHIAPTTTTASPPGTPSKNAATDPVEPTSPFVLRAPPSAK--SKLILQNMEEVLNSVK 65
            |.|.|.|       |:|.|...|.....|:  ||..|...|:....|  |..|....|:|::.|:
Worm     8 DENSLPS-------TSAPPEPIPEHKEHTE--EPKRPARRRSSLGIKIMSSFISSGSEDVMSPVQ 63

  Fly    66 QKHREKHKRK------------------------------------------------REEKRRA 82
            ::.:.|...:                                                |......
Worm    64 KRVQPKRMAQLKIAPLPLVQPPPPPRTRACQRPIRYSFDVGERVAVKPCLKSATKTPIRVRPADG 128

  Fly    83 ALMEDQKSTTEEVKANAKEKPQPLREKSSQENG----LKNGR----RRSSPLKSSTPVADNQSIM 139
            |::..:||.|::......:|.:....|:.|:.|    ||..:    |..:|..:..|   |..:|
Worm   129 AMIPPRKSLTQQAAQRVMQKYRRSMSKTPQKRGTSGKLKFNKICSIRVITPRPNYNP---NDLVM 190

  Fly   140 KHFAKAGKPENVGVSPVSTAKPK--PTT----------NVFEFMMNARNRSLGVNEGGAES-PAD 191
            .|........|.....:||.|.:  ||:          :||:|     |..:...:||..| |:.
Worm   191 PHSDDEEDTMNPNRERLSTVKLRLTPTSQAKLEQMQSEDVFQF-----NAEMVFGDGGGGSAPST 250

  Fly   192 QEIGSEAA--------------------TPTTKRKLLLQEWNERKGGAKRRLADEARGEFIEL-Q 235
            ..|.|.:|                    .|:::||.|:.       ||...|...|:.|...| :
Worm   251 SSIASYSAESVTETALESVNTKSVESKTRPSSRRKSLIL-------GAASPLKSPAKIEKPRLEE 308

  Fly   236 MEQRAKRLRKML-TKTDAKEVTAPS---------------------SAPTDPTVKRLRGRPRSRR 278
            .||::||.|:.| ...||.|....|                     ....:|..||   .|....
Worm   309 PEQKSKRSRRSLRLNPDAIEPPVKSCDLLEDEREESSSKKRENHDPGYDLEPLAKR---GPLKSE 370

  Fly   279 ISSMDAQNQIVESKPPVVKAKDQDPGTE----ELLSKLSSPTKKRDSLLGYFPKVESPKELAEKV 339
            |.|..|..   .:|.|||....:....|    |:..:.....:|......||...|...|...|.
Worm   371 IHSFFAPR---SAKKPVVSLDGEADSVEVNCVEMAVESEKKQRKNRRYSAYFGSAEKEVESISKP 432

  Fly   340 IIA---------------IETPPMET--------PKRRTLRR----KSQQETPIVAESTPSSR-- 375
            :.|               :|:..:|:        ||.||.|:    ||.:...:..::.||.:
Worm   433 LEAEKKRSRRSSAYSGNSVESKSLESKSLDKEVEPKVRTARKSMAAKSVEPKTLEKDAEPSRKSE 497

  Fly   376 -PRRSCVGKARYDYDLETSPGKQQK--------------AKP-----QKADESVEIIDLDNSNPA 420
             |.::....|:...::     |::|              |||     ..|.|:.|.|.:.:|..|
Worm   498 SPEKTVEPPAKSSEEI-----KEEKKKLKIRRSSAYFRVAKPLPTSDDAAPETEEEIVVISSPEA 557

  Fly   421 ATPKKLAPLFVRQLPKPSPDPSVLKARQAFLQSGVPDKIRQEQIRQKNFDQMYEDSYEVF----- 480
            ....|||.:|.:..|... :..:|:.::|..:|..|.            .|....|..||
Worm   558 PENGKLATIFSKSTPVVG-NKKMLELKKAETKSTPPT------------SQKPSSSGPVFSIFSP 609

  Fly   481 --------PRLAHIGCESFGSKNGPLDIPFA-----LRAEEEYSEVT-------KALPANKRRAK 525
                    |::..:.....||.:||....|:     :|.:|.:.::.       :.:|
Worm   610 KPVKPAVTPKVTTLSDSPMGSVSGPPSSSFSKKSNGVRRKEHWGDLCAETYQFFEKIP------- 667

  Fly   526 ASSITSCLPADFTSSKTLNKFNYATLPQLENKRGFVKLWKNDFDRFPTFKCYNQMREKYRHF--S 588
                  .|||.|                            .:|......|.:     |.|.|  .
Worm   668 ------ILPAIF----------------------------EEFAEIDDGKIF-----KSRSFDPK 693

  Fly   589 AIDSAQDTQQMGESLVVTRRT-RRSMEQNMAQNEEEAKPPPSA------PNGELLFTEKYKPLLF 646
            .:||.....::.|.|:...:. .||.|..||||     ||.|:      |....  |....|...
Worm   694 ILDSTGIVSELQEDLLELHKPYERSRELTMAQN-----PPDSSLEKLEVPQNSC--TTTIYPSTM 751

  Fly   647 EQVLVNLTPVQELREFLSSW------------SGNGGSNRNSQGMDDTFDMSND---SASMGSSS 696
            :.::........:|.:|..|            :...|..:..:..|:..:...|   ........
Worm   752 DSLVEGAEEEPTVRGWLRRWKRRVRKAMEREIAEQQGKKKKRKRRDEDHESDEDYEVEHQDDDLE 816

  Fly   697 NTMVLVGPSSSGKTNAVFTLANDMNFNVLEINAGMKRTGKKLIQELQEATQSHQIRKDGKAGGGS 761
            |.:||:|||..|||.....||...|..::.|.....|:|.::.:.||||.:||::  |.:.....
Worm   817 NPLVLIGPSGVGKTALFRALAKQENMRIISIGPETGRSGSEIKRNLQEALRSHRV--DQQPHPTR 879

  Fly   762 SQQLLQKLQKSGLKAKAAAVEP---PSEVRKSLILIEDADILFDNLD----AGFTDAIYTLA--- 816
            :....:.:.:     :..|..|   |.:..:||::.|..|:.|:.||    .|..:|:...|
Worm   880 TIPFYKTIPR-----ETPAPPPQLAPKDFVQSLVVFEHVDVFFETLDRHGILGLLEAVNEAAVPV 939

  Fly   817 --------------ASSKRPVIVVATDPNCAHLQRLMQQNIIH 845
                          ...:||.:.:..:.|...:|:.: ||:::
Worm   940 VFTCEQEWPRRWGQVELRRPHLEICLNRNQCRVQKYV-QNLVY 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376	17/127 (13%)
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	36/152 (24%)
Y53F4B.9	NP_497095.1	AAA	817..>874	CDD:214640	22/58 (38%)
Y53F4B.9	NP_497095.1	P-loop_NTPase	819..>858	CDD:304359	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I5329
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I3755
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R386
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.980