DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and AgaP_AGAP001290

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_321857.5	Gene:	AgaP_AGAP001290 / 1281887	VectorBaseID:	AGAP001290	Length:	1053	Species:	Anopheles gambiae

Alignment Length:	1097	Identity:	212/1097 - (19%)
Similarity:	389/1097 - (35%)	Gaps:	260/1097 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 NQSIMKHFAKAGKPENVGVSPVSTAKPKPTTNVFEFMMNARNRSLGVNEGGAESPAD-------Q 192
            :..|...|.:.|.    ...|....:|..|..|       :.:::.:::...|:.|.       .
Mosquito     2 SMDIRAFFGRGGS----ATKPAKAPEPAKTPTV-------KRKAVIISDDEDETKASPSRSSKKP 55

  Fly   193 EIGSEAATPTTKRKLLLQEWNERKGGAKRRLADEARGEFIELQMEQRAKRLRKMLTKTDAKEVTA 257
            |..|.:.|...|::.:::..:|.|..||.|              .:..|...:.|...:..:|.
Mosquito    56 EQNSPSTTGAVKKRRVIESDDEEKSPAKGR--------------HESTKPKPEKLKPVNVADVF- 105

  Fly   258 PSSAPTDPTVKRLRGRPRSRRISSMDAQNQIVESKPPVVKAKDQDPGTEELLSKLSSPTKKRDSL 322
             ||||    |||:. .|:..:..:::          ||.:.|.::...:|::.....|.||...
Mosquito   106 -SSAP----VKRVE-LPKIPKKKTLE----------PVEQVKLEELDDDEVIPVTPQPDKKMAR- 153

  Fly   323 LGYFPKVESPKELAEKVIIAIETPPMETPKRRTLRRKSQQETPIVAESTPSSRPRRSCVGKARYD 387
                 |..:..|.:||  ...|.|....|:.:.::|::.:|.|.|::.:|.         |.:..
Mosquito   154 -----KDRNGNERSEK--RTPEKPKATPPESKPVKRETSEERPTVSKKSPV---------KQKSV 202

  Fly   388 YDLETSPGKQQKAKPQKADESVEIIDLDNSNPAATP-------KKLAPLFV-----RQLPK---- 436
            .....||.:::.:...|.....:..|..:.|.:...       |:::.:..     ||.|.
Mosquito   203 EQQSASPSREKVSSKAKKKSDSDAADYKDPNESILTDEERHERKRMSAILYQKFKNRQGPANPGS 267

  Fly   437 ---PSPDPSVLKARQAFLQSGVPDKIRQEQIRQKNFDQMYEDSYEVFPRLAHIGCESFGSKNGPL 498
               |...|:.|:..| |:.:||.:.:.:::..|...|...:....|..:..|:   ..|...||.
Mosquito   268 KEIPEGKPNCLQGLQ-FVITGVLESMERDECAQVIKDLGGKVVGAVSKKCTHM---VVGDDAGPK 328

  Fly   499 DIPFA------LRAEEEYSEVTKALPANKRRAKASSITSCLPADFTSSKTLNKFNYATLPQLENK 557
            .|..|      ..:|:|..::.:.....|...|:||:.....|..:|:.:..|.:    |:.|.:
Mosquito   329 KIAQAEELGIVTLSEDELLDLIRVKSGQKPLKKSSSVKEAESAGGSSTSSKRKES----PKEEKE 389

  Fly   558 RGFVKLWKNDFDRFPTFKCYNQMREKYRHFSAIDSAQDTQQMGES---LVVTRRTRRSMEQNMAQ 619
               :|..|.|    |:      .|:..:......|      .|.|   ..|.|::..|.|....:
Mosquito   390 ---IKKMKTD----PS------PRKSPKELKTESS------KGRSPGKATVDRKSEHSKEAVKVK 435

  Fly   620 NEEEAKPPPS-----APN----------------------GELLFTEKYKPLLFEQVLVNL---T 654
            .|:.....||     :|.                      ..:.:.|||||...:|::..:   :
Mosquito   436 VEKSPSKQPSDGAKTSPRKLEPSTTVKRELSDYQKDIKSVDNMAWVEKYKPSSTKQIIGQMGANS 500

  Fly   655 PVQELREFLSSW-SGNGGSNRNSQGMDDTFDMSNDSASMGSSSNTMVLVGPSSSGKTNAVFTLAN 718
            .||.|..:|||| ..|.|:.::::   ....:.|||   |::....:|.||...|||.....:..
Mosquito   501 NVQRLTVWLSSWYKNNDGTKKHAK---PNPWVKNDS---GAAFKAALLSGPPGVGKTTTATLVCK 559

  Fly   719 DMNFNVLEINAGMKRTGKKLIQELQEATQSHQIRKDGKAG--GGSSQQLLQKLQKSGLKAKAAAV 781
            ::.|:.:|.||...|:.:.|.:|:.|...|..:     ||  ||.|:::..
Mosquito   560 ELGFDTVEFNASDTRSKRLLKEEVSELLNSKSL-----AGYFGGRSEKVSS-------------- 605

  Fly   782 EPPSEVRKSLILIEDADILFDNLDAGFTDAIYTLAASSKRPVIVVATDPNCAHLQRLMQQNI-IH 845
                   |.::|:::.|.:..|.|.|....:..|...|..|||.:..|.|...::.|:.... :.
Mosquito   606 -------KHVLLMDEVDGMAGNEDRGGMQELIALIKESHIPVICMCNDRNHPKIRSLVNYCFDLR 663

  Fly   846 FQAPNALNISRFLAVLSLMENCPIELDELISVYLYNQQNLRKTLMELQFYIQSGGDSTRDRTGGG 910
            |..|....|...:..:...|...:....|..:......::|:||..|..|  |.|.|.  .....
Mosquito   664 FNRPRVEQIKGAMMSVCFKEQLKLSPGVLEEIIAGTGGDVRQTLNHLALY--SAGKSM--AASLS 724

  Fly   911 IKSPTKTSNS-----RLATVDGSRIHQRFFEFFTSPQNVQYRIPFPVDFSLLRLNLPDLMASSAM 970
            :.|..|.::|     ::...|..|      :.|::..:....:....|......|:..|......
Mosquito   725 VDSAKKHADSAKKDIKIGPWDVIR------KVFSAEDHKHMTLNDKADLFFHDYNIAPLFVQENY 783

  Fly   971 LKEQQAAGGGSRTAAKRKSRSPKKAWLSSATGQKSDGHSSSLATLASFYDNISVASLMDSDCSDR 1035
            ||.|              .::|:..||.               .:|...|::|...:::......
Mosquito   784 LKVQ--------------PKAPRTEWLD---------------RIALTADSLSRGDMVERRIRSN 819

  Fly  1036 LQWHLSEEIGHLLVEQALQTGLATKECPYNLF-------------DKPVQRFSICQ--HLGNGVL 1085
            :.|       .||..||:.:.:...|.....|             .|.::|..:.|  |....|.
Mosquito   820 MAW-------SLLPVQAMFSSVMPGEFMEGHFTGQINFPGWLGKNSKSMKRKRLAQEIHDHTRVA 877

  Fly  1086 RSDSAKS--LDFEP-ALRSICRSEKERAGLERKSS----RFYHYLRNHTVNVTSFTT 1135
            .|.|.::  ||:.| .||||.:..:.|.......|    :.|..||....::...:|
Mosquito   878 TSGSRQAIRLDYAPHLLRSIVQPLQHRGAEGVHDSLEVIKEYRLLREDIDSLVELST 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	31/130 (24%)
AgaP_AGAP001290	XP_321857.5	COG5275	144..350	CDD:227600	43/226 (19%)
		BRCT	280..351	CDD:237994	15/74 (20%)
		AAA	541..670	CDD:214640	36/154 (23%)
		AAA	541..668	CDD:278434	35/152 (23%)
		HolB	633..835	CDD:223546	43/247 (17%)
		RFC1	806..959	CDD:285691	28/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5275
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900