DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment elg1 and atad5

DIOPT Version :9

Sequence 1:	NP_996103.1	Gene:	elg1 / 39770	FlyBaseID:	FBgn0036574	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_031750402.1	Gene:	atad5 / 100485754	XenbaseID:	XB-GENE-6257545	Length:	1728	Species:	Xenopus tropicalis

Alignment Length:	1568	Identity:	331/1568 - (21%)
Similarity:	535/1568 - (34%)	Gaps:	569/1568 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 APTTTT------ASPPGTPSKNAATDPVEPTSPFVLRAPPSAKSKLILQNMEEVLNSVKQKHREK 71
            :|.|.|      .|||.:.|.:|.|...:..|.|                       :|:|..|.
Frog   300 SPKTVTVHAQVHVSPPLSHSYSATTATKKIASIF-----------------------LKKKESEV 341

  Fly    72 HKRKRE------------EKRRA--ALMED----------------QKSTTEEVKANAKEKPQPL 106
            .|:..|            :||::  .::||                .|||..|.:...|...||.
Frog   342 DKKAAEPVCEQEPADLVVQKRKSNVVILEDDLELSVVEVENINYAKHKSTVAERQQFMKAFRQPG 406

  Fly   107 RE-KSSQENGLKNGRRRSSPLKSSTPVADNQSIMKHFAKAGKPE----NVGV------------- 153
            .. ||:.:..|||    .:|.:.|.....::...:..|..|..|    |.|.
Frog   407 EAGKSAGKKSLKN----KNPAEVSAQDGPDEGQQRALANKGGSEGHQTNQGADDHEETLAVKAFT 467

  Fly   154 -SPVSTAKPKPTTNVFEFMMNARNRSLGVNEGGAESPADQEIGSEAATPTTKRKLLLQEWNERKG 217
             ....:|.|||           :.:.|.|..|....|:  |..:.|.             |.|:.
Frog   468 SKTAGSAAPKP-----------KGKKLKVPRGRVSEPS--ECPASAI-------------NLRRS 506

  Fly   218 GAKR-----RLADEARG-EFIELQMEQRAKRLRKMLTKTD--AKEVTAPSSAPTDPTVKRLRGRP 274
            ...|     .|...|:| ...:|.::....:.|....|:|  ..||.:.|:....|.      |.
Frog   507 SRLRTCETPALNSPAKGHSMTDLPLQMSTPKGRVPCRKSDIYRAEVISISTEADSPI------RM 565

  Fly   275 RSRRISSMDAQNQIVESKPPVVKAKDQDPGTEELLSKLSSPTKKRDSLLGYFPKVESPKELAEKV 339
            |..|:||.             .:.::|..|.::|.      |.:.:.:|....|::..|:|.||.
Frog   566 RFTRLSSR-------------ARGRNQSFGPDDLF------TPRSNQVLASSKKIKKAKKLLEKA 611

  Fly   340 -IIAIETPPMETPKR-------RTLRRKSQQETPIVAESTPSSRPRRSC----VGKARYDYDLET 392
             .|.......|||:|       |:..:|:.|.:.::.:   ...|..||    :|:......:..
Frog   612 KAIQQNIGKPETPRRLSARQAARSADKKALQGSILIED---DETPETSCKDRELGRRNSLRSVND 673

  Fly   393 SPGKQQKAKPQKADESVEIIDLDNSN-----PAATPKKLA--PLFV-----RQLPKPSPDPSVLK 445
            ..||::|.:             .|||     ...:.|||.  ||..     .::.:.|.|....:
Frog   674 VLGKREKIR-------------KNSNILTGQSKCSGKKLKKHPLITVIDDSPEISENSLDEEHFR 725

  Fly   446 ARQAFLQSGVPDKIRQE----------------------QIRQKNFDQMYEDSYEVFPRLAHIGC 488
            |::.||.||:||.:::.                      .::|:|..||::     .|...|:.
Frog   726 AKREFLMSGLPDSLKRHIAKTTALMEAYALSGSSFQTLVHVQQRNDSQMWD-----MPPCLHLA- 784

  Fly   489 ESFGSKNGPLDIPFALRAEEEYSEVT--KALPANKRRAKASSITSCLP--ADFTSSKTLNKFNYA 549
             ..|.::..  :|...:......|.|  ||.||   ...|:.:....|  :|......|.:..::
Frog   785 -GLGDRSPA--VPDVAKLTMSLGEFTCVKAKPA---APVAAPLVYKRPVFSDAARDLLLEEIRFS 843

  Fly   550 TLPQLENKR---------------------GF-------------VKLWKNDF----------DR 570
            . ||...||                     ||             |.||:|..          ..
Frog   844 N-PQFPVKRFLSIFLKKQSDSVALLDSHKPGFQPQNSVAGSKVTEVILWENGTRGKRKRKDSPGN 907

  Fly   571 FPTFKCYNQMREKYRHFSAIDSAQDTQQM-----GESLVVTRRTRRSMEQN-------MAQNEEE 623
            .|..|..:...........:.|:.|...:     .|:....:|.::.:|..       :||   |
Frog   908 KPKRKRSDGKAAGQNEICDLTSSPDEASLQPSTQAETRAPVQRRQKCLEHKTTLELDILAQ---E 969

  Fly   624 AKPPPS-APNGELLFTEKYKPLLFEQVLVNLTPVQELREFLSSWSGNGGSNRNSQ------GMDD 681
            .||..: |...::|:||||:|....:::.|...:|:|..:|..|.........||      ...|
Frog   970 RKPASTDAVCDDVLWTEKYQPQNTSEMIGNSAAIQKLYSWLKDWKVRADKEERSQMQKTEKEKSD 1034

  Fly   682 TFDMSN----DSASMGSS-SNTMVLVGPSSSGKTNAVFTLANDMNFNVLEINAGMKRTGKKLIQE 741
            |::.|:    ||.|...| .||:::.||...|||.||:..|.::.|.|.|:||..:|:|::::.:
Frog  1035 TWEQSDFMTLDSDSEEESLCNTVLITGPPGVGKTAAVYACAQELGFKVFEVNASCQRSGRQILAQ 1099

  Fly   742 LQEATQSHQIRKDGK-------AGGGSSQQLLQKLQ---------------------KSGLKAKA 778
            |:|||||||:.:.|.       ....||.:..:||.                     :.||..|:
Frog  1100 LKEATQSHQVDQQGANSHKPCFFSSFSSTKSPRKLNSPKNVVSSPRKPPASPRGTGLRKGLAPKS 1164

  Fly   779 AA--VEPPSEVR--------------------------------------------------KSL 791
            .|  .:||:..|                                                  .||
Frog  1165 LANFFKPPANKRTEEKPNAAEASKGVAKGTLRLREAETKPHKSQDATAEKESGSEEKHRKFATSL 1229

  Fly   792 ILIEDADILFDNLDAGFTDAIYTLAASSKRPVIVVATDPNCAHLQRLMQQNI---IHFQAPNALN 853
            ||.|:.|::||: |.||..||.|..:::|||||:..:||...    .|...|   |||:||:..|
Frog  1230 ILFEEVDVIFDD-DVGFVSAIKTFMSTTKRPVILTTSDPTFG----FMFDGIFEDIHFKAPSMTN 1289

  Fly   854 ISRFLAVLSLMENCPIELDELISVYLYNQQNLRKTLMELQFYIQSGGDSTRD-------RTGGG- 910
            ::.:|.||.|.||...|..:.::....|:.::|::|:.|||:..|||.:..:       |..||
Frog  1290 VATYLQVLCLAENLRTETKDFLTFLSANKCDIRQSLLHLQFWASSGGGALIEKPPPQLCRQQGGP 1354

  Fly   911 --------------------IKSPTKTSNSRLATV---DGSRIHQRFFEF-----FTSPQNVQYR 947
                                |.|||:...|.:...   :|:.:.|...||     :.:..|:::.
Frog  1355 ITELPTCNIGCTESFMGLNNIISPTEGLLSFIKNTQKQEGNVLQQLLTEFQLNNVYFTLSNLEFL 1419

  Fly   948 IPFPVDF--------------------------------------SLLRLNLPDLMASSAM---- 970
            :|.||..                                      .||.||..||..|.::
Frog  1420 LPLPVHVGPPAVPLESSECPPAGLQQNGTADESPMKMSVQMKKRKKLLILNDSDLFDSDSVDEIF 1484

  Fly   971 --------LKEQQAAGG--------GSRTAAKRKSRSPKKAWLSSATGQKSDGHSSSLATLASFY 1019
                    .||.:..|.        |:..|::|..:.          |||:..| ..|.:||.|.
Frog  1485 SLVSGVQSQKEAEQKGPPVADRGECGAHPASERHRQE----------GQKASVH-HCLGSLADFV 1538

  Fly  1020 DNISVASLMDSDCSDRLQ-------------------------WHLSEEIGHLLVEQALQTGLAT 1059
            ||:|.......:..||.:                         |...:..|.:   :|....||.
Frog  1539 DNMSQIDCFTCNPMDRAELCNGNWTESRIKDGLCDGLRLETRDWSNRQSSGEV---RATIEALAF 1600

  Fly  1060 KECPYNL--------------FDKPVQRFS--ICQHLGN---------------------GVLRS 1087
            ::|..||              ...|.:..:  :.:..||                     .||.|
Frog  1601 QKCLSNLSAAIAPSPETCTTSSHPPTEALTLHVSEERGNVCFCQGETSSSVAEKRLAVVRTVLSS 1665

  Fly  1088 DSAKSL--------DFEPALRSICRSE--KERAGLERKSSRFYHYLRNHTVNVTSFTTDYFDTAC 1142
            .|..||        ::.|||||:|||:  ||:   |:...||.||.....:.::..|.
Frog  1666 RSFFSLGNRQCNVTEYLPALRSMCRSQRLKEQ---EKTKRRFLHYFEGIHLELSKATV------- 1720

  Fly  1143 STFQSAAP 1150
            |:..:|.|
Frog  1721 SSLAAAFP 1728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
elg1	NP_996103.1	Selenoprotein_S	<57..129	CDD:284376	22/102 (22%)
elg1	NP_996103.1	P-loop_NTPase	699..828	CDD:304359	54/208 (26%)
atad5	XP_031750402.1	PRK04195	981..>1096	CDD:235250	37/114 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3479
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004592
OrthoInspector	1	1.000	-	-		oto104251
Panther	1	1.100	-	-	LDO	PTHR23389
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R386
SonicParanoid	1	1.000	-	-		X5719
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.180