DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LIFR and Dscam1

DIOPT Version :9

Sequence 1:XP_016864951.1 Gene:LIFR / 3977 HGNCID:6597 Length:1115 Species:Homo sapiens
Sequence 2:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster


Alignment Length:1283 Identity:259/1283 - (20%)
Similarity:413/1283 - (32%) Gaps:410/1283 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    30 SWMVDNKRMRTASNFQWLLSTFILL------YL-MNQVNSQKKG------------APHDLKCVT 75
            ||.:|.|::  |:|.::.:..::.:      || :..|::...|            |.|..|...
  Fly   465 SWELDGKKI--ANNDRYQVGQYVTVNGDVVSYLNITSVHANDGGLYKCIAKSKVGVAEHSAKLNV 527

Human    76 NNLQ------------------------------VWNCSWKA----------PSGTGRGTDYEVC 100
            ..|.                              ||....:|          |:||       :.
  Fly   528 YGLPYIRQMEKKAIVAGETLIVTCPVAGYPIDSIVWERDNRALPINRKQKVFPNGT-------LI 585

Human   101 IENRSRSCYQ------------------LEKTSIKIPALSHGDYEITINSLHDFGSSTSKFTLNE 147
            |||..|:..|                  ||...:.:|.:....||..||    .|.|...|...:
  Fly   586 IENVERNSDQATYTCVAKNQEGYSARGSLEVQVMVLPQIVPFAYEDLIN----MGDSIDLFCQIQ 646

Human   148 QNVSLIPDTPEILNLSADFSTSTLYLKWNDRG--SVFPH-RSNVIWEIKVLRKESMELVKLVTHN 209
            :.     |.|..::.|.:.|.       .|.|  .|.|. |:|.|       .|...::.:.:.:
  Fly   647 KG-----DRPIKVHWSFERSA-------GDYGFDQVQPQMRTNRI-------SEKTSMISIPSAS 692

Human   210 TTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWS-DWSPVKNISWIPDSQTKVF 273
            ....|:||                      |...|.  :|...:| |.:......||.:      
  Fly   693 PAHTGRDT----------------------CIASNK--AGTTTYSVDLTVNVPPRWILE------ 727

Human   274 PQDKVILVGSDITFCC---------VSQEKVLSALIGHTNCPLIHLD---GENVAIKIRNISVSA 326
            |.||....|||....|         |:.:|.    :|.|  |..:.|   .:|:.::...:.|..
  Fly   728 PTDKAFAQGSDAKVECKADGFPKPQVTWKKA----VGDT--PGEYKDLKKSDNIRVEEGTLHVDN 786

Human   327 SSGTNVVFTTEDNIFG--------TVIFAGYPPD-------------TPQQLNCETHDLKEIICS 370
            ...||..:...:.|.|        .:|....||:             .|..|.||....|.|...
  Fly   787 IQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIGIL 851

Human   371 WNPGRVTALVGPRATS-YTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPL 434
            ||...:.  :.|:..: ||:.|......|....:...|..|...|           ||..|.|..
  Fly   852 WNMNNMR--LDPKNDNRYTIREEILSTGVMSSLSIKRTERSDSAL-----------FTCVATNAF 903

Human   435 GRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLP--GNFAKINFLCEIEIKKSN-SVQE 496
            |...::|  |:..:..|..|.:.||.|.:..:|:|||..|  ||.....::  ||.|:|. |..|
  Fly   904 GSDDASI--NMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYI--IEFKRSRASWSE 964

Human   497 QRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWR 561
            ...|.:.|....:   .:.||:|.|  |:.||...|.....|:.|.....:|.|.:||..|...:
  Fly   965 IDRVIVPGHTTEA---QVQKLSPAT--TYNIRIVAENAIGTSQSSEAVTIITAEEAPSGKPQNIK 1024

Human   562 EWSSDGKNLIIYWKPLPINEANGKILSY-------NVSCSSDEETQSLSEIPDPQHKAEIRLDK- 618
            ....:...:.:.|||.|..|.||:||.|       |.:.|...||.:.......:|..|::..: 
  Fly  1025 VEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRV 1089

Human   619 -NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNS 682
             ..|.:.:.|.|.:|:.|.|:           :.:|....|     |....|:.|.      |.:
  Fly  1090 YTQYSVVIQAFNKIGAGPLSE-----------EEKQFTAEG-----TPSQPPSDTA------CTT 1132

Human   683 SRSEPCLMDWRKVPSNSTETVIE--------SDEFRPGIRYNF--------FLYGCR---NQGYQ 728
            ..|:...:.|...|..|...||:        |||:....:.::        .|:|.:   |...|
  Fly  1133 LTSQTIRVGWVSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQ 1197

Human   729 LLRSMIG-----------YIEELAPIVAPNFTVEDTSA-----DSILVKWEDIPVEELRGFLRGY 777
            :|.:..|           ..|...| .||.    |..|     .:|||.|.  |..:..|.:..|
  Fly  1198 VLATTAGGDGVRSVPIHCQTEPDVP-EAPT----DVKALVMGNAAILVSWR--PPAQPNGIITQY 1255

Human   778 LFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKS 842
            ..|        ||   .|...::.|.:.:... |.:....:|:....|...:.|.|..|.|.:..
  Fly  1256 TVY--------SK---AEGAETETKTQKVPHY-QMSFEATELEKNKPYEFWVTASTTIGEGQQSK 1308

Human   843 MYVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPD---------IPNPE--- 895
            ..|....:.|        |..:|......|:            ||..|         .|.||   
  Fly  1309 SIVAMPSDQV--------PAKIASFDDTFTA------------TFKEDAKMPCLAVGAPQPEITW 1353

Human   896 NCKALQFQKSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPE 960
            ..|.::|..:                  :.:.||...|...|..:.:.....:...|:....:..
  Fly  1354 KIKGVEFSAN------------------DRMRVLPDGSLLIKSVNRQDAGDYSCHAENSIAKDSI 1400

Human   961 NHVVVSYCPPIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGG--AGYKPQM 1023
            .|.::...||      .:|....:..|...:.:        :.|| .|.:..|:.|  ..|||:.
  Fly  1401 THKLIVLAPP------QSPHVTLSATTTDALTV--------KLKP-HEGDTAPLHGYTLHYKPEF 1450

Human  1024 ------HLPINS---TVE----------------DIAAEEDLD----KTAGYRPQANVNTWNLVS 1059
                  .:.::|   .:|                :|.|.|..|    :|.|.:|:.         
  Fly  1451 GEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILNTRTKGQKPKL--------- 1506

Human  1060 PDSPRSIDSNSEIVSF--------GSPCSINSRQFLIPPKDEDSPKSN 1099
            |:.||.|:.:|..||.        |.|.|    .|::..|..|..:.|
  Fly  1507 PEKPRFIEVSSNSVSLHFKAWKDGGCPMS----HFVVESKKRDQIEWN 1550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LIFRXP_016864951.1 None
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352 13/63 (21%)
IGc2 446..517 CDD:197706 10/53 (19%)
I-set 533..618 CDD:254352 13/91 (14%)
IGc2 544..607 CDD:197706 11/69 (16%)
Ig 641..714 CDD:143165 19/115 (17%)
IGc2 735..804 CDD:197706 16/74 (22%)
I-set 819..914 CDD:254352 24/109 (22%)
Ig 833..921 CDD:299845 24/102 (24%)
FN3 918..1011 CDD:238020 30/99 (30%)
FN3 1018..1116 CDD:238020 24/108 (22%)
FN3 1124..1217 CDD:238020 18/98 (18%)
FN3 1222..1312 CDD:238020 24/108 (22%)
Ig 1339..1406 CDD:299845 11/84 (13%)
FN3 1409..1499 CDD:238020 18/104 (17%)
FN3 1504..1584 CDD:238020 15/60 (25%)
Dscam_C 1890..2008 CDD:289151
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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