DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LIFR and sdk

DIOPT Version :9

Sequence 1:XP_016864951.1 Gene:LIFR / 3977 HGNCID:6597 Length:1115 Species:Homo sapiens
Sequence 2:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster


Alignment Length:1246 Identity:229/1246 - (18%)
Similarity:419/1246 - (33%) Gaps:380/1246 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    30 SWMVDNKRMRTASNFQWLL-----STFILLYLMNQVNSQKKGAPHDLKCVTNNLQVWNCSWKAPS 89
            :|:.:...:  :::.:|:|     :..:..:.::.||...:|:|.:...|....|      :|||
  Fly   741 NWITELSNV--SADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQ------EAPS 797

Human    90 GTGRG------------TDYEVCIE-------------------NRSRSCYQ-----LEKTSIKI 118
            |...|            |.::..:|                   |.....||     .::..:..
  Fly   798 GPPVGFVGSARSMSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQ 862

Human   119 PALSHGDYEITINSLHDFG----SSTSKFTLNEQNVSLIPDTPEILNLSADFSTST-LYLKWNDR 178
            ..::..||.:.|.:.::.|    :..||....|.    :|:.|. .|:..:...|| ...:|...
  Fly   863 ELITWKDYIVQIAAYNNMGVGVYTEGSKIKTKEG----VPEAPP-TNVKVEAINSTAARCRWTPP 922

Human   179 GSVFPHRSNVI--------WEIKVLRKESMELVK------------LVTHNTTLNGKDTLHHWSW 223
            .   |.:.|.|        |:.:::..|..::.:            |......|.|.:....:: 
  Fly   923 N---PQQINGINQGYKIQAWQRRLIDGEWRDIERRMKTVPPSLIDPLAEQTAILGGLEKFTEYN- 983

Human   224 ASDMPLECAIHFVEIRCYID-----------------------NLHFSGLEEWSDWSPVKNISWI 265
                        :.:.|:.|                       .|||..:.:.|    || :.|.
  Fly   984 ------------ISVLCFTDPGDGVASSQVAVMTMDDVPDEVTGLHFDDVSDRS----VK-VLWA 1031

Human   266 PDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGT 330
            |...:      ..||.|..:.:....:...|.:         .:|..::..:.:..:..:.....
  Fly  1032 PPRAS------NGILTGYTVRYQVKDRPDTLKS---------FNLTADDTELTVNQLQATTHYWF 1081

Human   331 NVVFTTEDNIFGTVIFAGYP-------------PDTPQQLNCETHDLKEIICSWNPG-------- 374
            .:|..|.       :.:|.|             |..|..|.....:...::..:.||        
  Fly  1082 EIVAWTR-------VGSGIPKTATIQSGVEPVLPHAPTALALSNIEAFSVVLQFTPGFDGNSSIT 1139

Human   375 --RVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRS 437
              :|........|.:|:.|      :....||..|      :..::|..: |...|:|.|.:|.|
  Fly  1140 KWKVEGQTARNMTWFTICE------INDPDAETLT------VTGLVPFTQ-YRLRLSASNVVGSS 1191

Human   438 QSTILVNITEKVY---PHTPTSFKVKDINSTAVKLSWHLP-------GNFAKINFLCEIEIKKSN 492
            :.:......:.:.   .|.|.:..|:.:::..:::.| :|       ||....|...:..:|...
  Fly  1192 KPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRW-IPLQQTEWYGNPRGYNISYKQLVKTPG 1255

Human   493 SVQ-EQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKG 556
            ::: ..|:|.|:....:|::  ||.|..:|||..::....:.  ..||.|:.....|.||.||.|
  Fly  1256 TIKYVPRSVVIEDHTANSHV--LDSLEEWTLYEVKMNACNDV--GCSKESDTAVERTREAVPSYG 1316

Human   557 PDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL--SEIPDPQHKAEIRLDKN 619
            |...:..::....:::.|..:|....||:|..|.|..::.:..|.:  ..||:.........:..
  Fly  1317 PLDVQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIPNNATFTTTLTELK 1381

Human   620 DYI---ISVVAKNSVG----SSPPSKIASME----------IPNDDLKIEQVVGMGKGILLTWH- 666
            .|:   :.|:|...:|    |:||.::.:.|          .|:..|.:.:::         |. 
  Fly  1382 KYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDVSLTMARII---------WDV 1437

Human   667 -YDPN-----MTCDYVIK---WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGC 722
             .|||     ....|.:.   ..|.||..|        ||:.|   ..:.|..||..|:|.....
  Fly  1438 PVDPNGKILAYQVTYTLNGSAMLNYSREFP--------PSDRT---FRATELLPGKYYSFSCTAQ 1491

Human   723 RNQGYQLLRSMIGYI-----EELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGF--LRGYLFY 780
            ...|:..:.:.:.|.     ...||.| |..:.....|..|...|  .|..:  ||  ||.|   
  Fly  1492 TRLGWGKIATALVYTTNNRERPQAPSV-PQISRSQIQAHQITFSW--TPGRD--GFAPLRYY--- 1548

Human   781 FGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYV 845
                   |.:||..| ||.....:.: |.|..:.....|:...:|...::|..|  :||.    .
  Fly  1549 -------TVEMRENE-GRWQPLPERV-DPSLSSFTAVGLRPYMTYQFRIQATND--LGPS----A 1598

Human   846 VTKENSVGLIIAILIPVAVAVIVG-------VVTSILCYRKREWIKETFYPDIPNPENCKALQFQ 903
            .::|:    :|...:|.|.||.||       ..||:    :.:|                     
  Fly  1599 FSRES----VIVRTLPAAPAVGVGGLKVVPITTTSV----RVQW--------------------- 1634

Human   904 KSVCEGSSALKTLEMNPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAE--PENHVVVS 966
                   |||:|...|    .:......|..:.::.|    .|.|.:...::|..  .||.||:|
  Fly  1635 -------SALETALWN----GDASTGGYRILYQQLSD----FPTALQSTPKTDVHGINENSVVLS 1684

Human   967 ----------------------YCPP---IIEEEIP--NPAADEAGGTAQVIYIDVQSMYQPQAK 1004
                                  ..||   .:.|.:|  .|.|.:|   |.:...:|:.:::|   
  Fly  1685 DLQQDRNYEIVVLPFNSQGPGPATPPAAVYVGEAVPTGEPRAVDA---APISSTEVRLLWKP--- 1743

Human  1005 PEEEQENDPVGG------AGYKPQMHLPINSTVEDIAAEED---------LDKTAGYRPQANVNT 1054
            |::..:|..:.|      ..|.||...|.....|:|.....         |||...||.|  :..
  Fly  1744 PKQSMQNGDILGYKIYYLVTYSPQALEPGRKWEEEIEVVSATATSHSLVFLDKFTEYRIQ--LLA 1806

Human  1055 WNLVSPDSPRS 1065
            :| .:.|.|||
  Fly  1807 FN-PAGDGPRS 1816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LIFRXP_016864951.1 None
sdkNP_001284756.1 Ig 71..157 CDD:299845
I-set 72..150 CDD:254352
Ig 172..245 CDD:299845
IG_like 280..356 CDD:214653
Ig 280..343 CDD:299845
IG_like 375..450 CDD:214653
Ig 378..447 CDD:143165
Ig 506..587 CDD:299845
IG_like 506..587 CDD:214653
I-set 592..682 CDD:254352
Ig 595..682 CDD:299845
FN3 686..789 CDD:238020 7/49 (14%)
FN3 798..893 CDD:238020 13/94 (14%)
FN3 901..1005 CDD:238020 15/120 (13%)
fn3 1011..1094 CDD:278470 16/109 (15%)
FN3 1108..1202 CDD:238020 19/106 (18%)
FN3 1210..1308 CDD:238020 21/102 (21%)
fn3 1317..1402 CDD:278470 15/84 (18%)
FN3 1415..1507 CDD:238020 21/111 (19%)
FN3 1513..1608 CDD:238020 29/121 (24%)
fn3 1617..1708 CDD:278470 20/130 (15%)
FN3 1722..1823 CDD:238020 26/104 (25%)
FN3 1828..1920 CDD:238020
FN3 1927..2016 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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