Protein Alignment Strump and WASHC5

DIOPT Version :10

• Sequence 1: NP_648840.1
• Gene: Strump / 39766
• FlyBaseID: FBgn0036571
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_055661.3
• Gene: WASHC5 / 9897
• HGNCID: 28984
• Length: 1159
• Species: Homo sapiens
• Alignment Length: 1198
• Identity: 527/1198 - (43%)
• Similarity: 772/1198 - (64%)
• Gaps: 59/1198 - (4%)

  Fly     1 MSFLDDNNACGQNLLNIVSVGNSIIAEILRLKDYVPSIYRLDNKADKAKYGELILDFSYFKIAED 65
            :.||.:||.|||.:|.|||.||:||||:|||.:::|:::||.::||:.|||::|.||||||..|.
Human     2 LDFLAENNLCGQAILRIVSCGNAIIAELLRLSEFIPAVFRLKDRADQQKYGDIIFDFSYFKGPEL 66

  Fly    66 HERRIEQSPELTELDDEARA-QLPLITRFYLAFQSIHHYASDLQQYIEELNTGYYIQQTLETVLQ 129
            .|.:::..|||.:||:|.|. .:.::|||||||||:|.|..||.:|:::||.|.||||||||||.
Human    67 WESKLDAKPELQDLDEEFRENNIEIVTRFYLAFQSVHKYIVDLNRYLDDLNEGVYIQQTLETVLL 131

  Fly   130 EEEGRQLLCESLYLFGVILLMVDFHIPGDVRERLLIAYYRYSGGDATPSGDESNIHDVCLLLRST 194
            .|:|:|||||:|||:||:||::|..|.|:||||:|::|||||   |..|..:||:.|:|.|||||
Human   132 NEDGKQLLCEALYLYGVMLLVIDQKIEGEVRERMLVSYYRYS---AARSSADSNMDDICKLLRST 193

  Fly   195 GYVHPSIAAKVLGLGGKQAGARAASLVVPRYPEAYFSRFRFDENFVDLVVARLRCDDIYNQLNLY 259
            ||             ..|.||:..|    .|||:||.|...:|:|:.:|:.|||.||||||::.|
Human   194 GY-------------SSQPGAKRPS----NYPESYFQRVPINESFISMVIGRLRSDDIYNQVSAY 241

  Fly   260 PHPAHRSTALSTQAAMLYVCLYFCPQVLHSQGSQMREIVDKFFCDNWTISVYMGMTVNLVDAWLD 324
            |.|.||||||:.|||||||.|||.|.:||:..::|||||||:|.|||.||:|||:||||||||..
Human   242 PLPEHRSTALANQAAMLYVILYFEPSILHTHQAKMREIVDKYFPDNWVISIYMGITVNLVDAWEP 306

  Fly   325 FKAARSAIENVISPPAIKALCQQQKEQLGKITQKTQEIVREGVLNDNFVLEHANKIIHLMRQSNV 389
            :|||::|:.|.:....::....:......::..:.|:.::||.|.:..||::..|:::.:|..||
Human   307 YKAAKTALNNTLDLSNVREQASRYATVSERVHAQVQQFLKEGYLREEMVLDNIPKLLNCLRDCNV 371

  Fly   390 LLRWFCLHTSREVFIFAHTA-----TLTGQVQKCVLHELQFNRNTLYNLLLNCSQMELSVREFLA 449
            .:||..|||       |.:|     ....|::..:|.:.::|...|:.|||:.:|.|..::|...
Human   372 AIRWLMLHT-------ADSACDPNNKRLRQIKDQILTDSRYNPRILFQLLLDTAQFEFILKEMFK 429

  Fly   450 EIQQTKEERWTKSREEAMQRLNELSEAFAGSRPLSKIEQNPQLQQWFGEVAGRLQKLELSRPQKS 514
            ::...|:.:|...::|..:|:.||::.|:|.:||:::|:|..||.||.|::.::..|.......:
Human   430 QMLSEKQTKWEHYKKEGSERMTELADVFSGVKPLTRVEKNENLQAWFREISKQILSLNYDDSTAA 494

  Fly   515 GRLIIQVMQALDDVQEYHNLHSNMLVKQQLQETRDMLNQMAQLINLKEDIEIHIQMITDFSYAWH 579
            ||..:|::|||::|||:|.|.||:.|.|.|.:||..|:||.:.||:||::.|.:|::.|.|:||.
Human   495 GRKTVQLIQALEEVQEFHQLESNLQVCQFLADTRKFLHQMIRTINIKEEVLITMQIVGDLSFAWQ 559

  Fly   580 LLQFDFTPPMQEHIKRQPQAVIGIRAVFLKLASTLEVPLMRINQARSEDLVSVSNYYSTELANFL 644
            |:. .||..|||.|:..|..|..:||.||||||.|::||:|||||.|.||:|||.|||.||.:::
Human   560 LID-SFTSIMQESIRVNPSMVTKLRATFLKLASALDLPLLRINQANSPDLLSVSQYYSGELVSYV 623

  Fly   645 RRVLQIVPETMFSILAKIIYLLTNVIKEFPTKVEKERLKDYAQFEERAKVAQLTNSIAVFTKGIL 709
            |:||||:||:||:.|.|||.|.|:.|.|.||:::|::|:||||...|.:||:||::|::||:|||
Human   624 RKVLQIIPESMFTSLLKIIKLQTHDIIEVPTRLDKDKLRDYAQLGPRYEVAKLTHAISIFTEGIL 688

  Fly   710 MMKTTLVGVIELDPKQLLEDGIRKELVNHLANAYNLGLIFTPEKGKTPVQLLQQKLQALAKTIEG 774
            ||||||||:|::|||||||||||||||..:|.|.:.||||.|.  ..|.:|: .||:.|..|::|
Human   689 MMKTTLVGIIKVDPKQLLEDGIRKELVKRVAFALHRGLIFNPR--AKPSELM-PKLKELGATMDG 750

  Fly   775 YRRSFEYIEDYLRVQGLRILLEESQRIINYNVEKECNAFLRNKVQEFQSEHQSQIIPIPNFPPLL 839
            :.||||||:||:.:.||:|..||..||||||||:|||.|||.|:|::||.:||..||||.|.|:
Human   751 FHRSFEYIQDYVNIYGLKIWQEEVSRIINYNVEQECNNFLRTKIQDWQSMYQSTHIPIPKFTPV- 814

  Fly   840 GDPSNNFIGRLAHEILRCTDPKQTIFLDLKSTWYEKKAPHQEVLAGSGFFEILREALAPAGMVGL 904
             |.|..|||||..||||.||||.|..:|..:|||:.|. ||||.:...|.|| :..|...|:.||
Human   815 -DESVTFIGRLCREILRITDPKMTCHIDQLNTWYDMKT-HQEVTSSRLFSEI-QTTLGTFGLNGL 876

  Fly   905 ERLYAHMLADELKRNLERLQRNLTSDRMWVDTLAALTRELEARDFPTPEVSKQPLKYYQAYTQRW 969
            :||...|:..||:..|...|:.:..||...|||..|...:.    |...:.....|.|.:...:.
Human   877 DRLLCFMIVKELQNFLSMFQKIILRDRTVQDTLKTLMNAVS----PLKSIVANSNKIYFSAIAKT 937

  Fly   970 LKVWPTLLDWVLCIGQKQLLRREIAGELSFSSKCDAKLLENTADTLNKALLLEL-------SLSK 1027
            .|:|...|:.::.:||.|:||::||.||::|.:.|:|.|....:.||||||.::       ||..
Human   938 QKIWTAYLEAIMKVGQMQILRQQIANELNYSCRFDSKHLAAALENLNKALLADIEAHYQDPSLPY 1002

  Fly  1028 DLCDEKGVVMLTELQETLLYTGNFEPLEQVFLITKNTHNMALFMFLFTIAHLGRMQHSTITDCLL 1092
            ...|.   .:|.|:...|...|...||.::::.||......:..|||.||.|.::|::.....:.
Human  1003 PKEDN---TLLYEITAYLEAAGIHNPLNKIYITTKRLPYFPIVNFLFLIAQLPKLQYNKNLGMVC 1064

  Fly  1093 PKSAKDNIDNVPFIVGLVTILQQFHKNVKMLYISYMSQYVVTVSEAQLLDKEI--LGPEVVTALH 1155
            .|.. |.:|..|.::||:|:|:|||......:::.:.|::.:..| |...::|  :..:||.||.
Human  1065 RKPT-DPVDWPPLVLGLLTLLKQFHSRYTEQFLALIGQFICSTVE-QCTSQKIPEIPADVVGALL 1127

  Fly  1156 FLLAFIRIARLPLGVLEQRIPNIILSEY 1183
            ||..::|..:||..|.|..:||.|..|:
Human  1128 FLEDYVRYTKLPRRVAEAHVPNFIFDEF 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Strump	NP_648840.1	Strumpellin	22..1132	CDD:463035	497/1122 (44%)
WASHC5	NP_055661.3	Strumpellin	23..1103	CDD:463035	497/1122 (44%)