DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf4 and taf4

DIOPT Version :9

Sequence 1:	NP_001137958.1	Gene:	Taf4 / 39765	FlyBaseID:	FBgn0010280	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001072285.1	Gene:	taf4 / 779738	XenbaseID:	XB-GENE-488490	Length:	1033	Species:	Xenopus tropicalis

Alignment Length:	1162	Identity:	353/1162 - (30%)
Similarity:	495/1162 - (42%)	Gaps:	273/1162 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SQPLPN-------GTISIAGNPGAVIS-TAQLPNT-TTIKTIQAGIGGQHQGLQQVHHVQQQQQS 71
            ||.|.|       |..|..|.|.|.|. :.::|.| ..:..:|.|          |.:.:.|..:
Frog    56 SQALANHVTSPGVGAASAGGQPEAKIGLSPEVPKTGAAVPGVQGG----------VINSRPQTTA 110

  Fly    72 QQQQQQQQQTQSVGA-TQTQTLVIKSNHHAVTLPAGLVSSAPAGIVTMTKTINQAGQPLLNSMLP 135
            |....|....::.|| :|.::.|:  .:.|.|||.   .|:..|.....:|:| ....::||..|
Frog   111 QPDGTQSAIPEAPGALSQAKSGVL--GNMASTLPN---HSSGNGKNATLQTMN-GSNVVINSHGP 169

  Fly   136 AG----------VVVGMRQQAPSQQQQKNVPTNPLSRVVINSHMAGVRPQSPSITLSTLNTGQTP 190
            .|          ..||:....|:...:..|  ||.:..||.:...|....:.|: :|:.:|....
Frog   170 GGHGTPYQGNSNAAVGLVNNGPAPVAKGGV--NPGANTVIQTSFLGTTNVASSV-ISSSSTSTAG 231

  Fly   191 ALLVKTDNGFQLLRVGTTTG----PPTVTQTITNTSNNSNT--TSTTNHPTTTQIRLQTVPAAAV 249
            |.      |.|....|..|.    .|.:.|.:..|.|.|||  .|..:.|....:::...|:..:
Frog   232 AA------GQQAGMAGVPTSVALVRPLLHQGVPATQNGSNTVINSPLSAPAGVSLQMNNQPSPVI 290

  Fly   250 SRYQQQQ--QHQQQSQQQQ------QSQQQQH-----ATSTTASTSIALRKTIVRTSSTVPSSNN 301
            .....:.  |..||||...      |:.|..|     |.|...:.:...:.|:    |.||.  |
Frog   291 KSESPKTIIQPPQQSQPNPGNMVLGQTMQAGHPGPGGAVSAPGAPTGMGKATV----SAVPP--N 349

  Fly   302 NNNSINATTNTTTTTTTNNNNKPATNQQQQQ----QKLQ------------------QQQHLKAQ 344
            ...:..|.......|.|.....|...|.||.    |..|                  .||.|...
Frog   350 LPRTPTALAGGIRATITPPMLAPRVPQPQQNPASVQNFQLPPGMVLVRSESGQLLMIPQQALAQM 414

  Fly   345 QQQKQQQASAAAAAAAAAANVAATIKIKQNSMTNTTATSN----IIVNSVASSG---YANSSQPP 402
            |.|.|.||.|.|.|.|.:.:        ||:|....||..    :.:::|.|.|   .|....|.
Frog   415 QAQAQAQAQAQAQAQAQSQS--------QNTMVPRPATPTSAPPVQISAVQSPGAPLLARQVTPT 471

  Fly   403 HLTQLNAQAPQLPQ-ITQIQTIPAQQSQQQQVNNVSSAG-GTATAV-----------SSTTAATT 454
            .:.|: .|||...| .|.:|..|..|:|....:...:|. ||||||           ::|.||.|
Frog   472 IIKQV-TQAPTTVQPTTTLQRPPVVQNQIVLGSTAQTATLGTATAVQTGAAQRPVQGAATPAAAT 535

  Fly   455 TQQGNTKEKCRKFLANLIEL--STREPKPVEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQP 517
            |:.....:||:.||:.||:|  |.::......||:.|:..|::..:|.|:|..||.|.||:||||
Frog   536 TETMENVKKCKNFLSTLIKLASSGKQSSETAANVKELVHNLLDGKIEAEDFTSRLYRELNSSPQP 600

  Fly   518 CLIGFLKKSLPLLRQALYTKELVIEGIKPPPQHVLGLAGLSQQLPKIQAQIRPIGPSQTTTIGQT 582
            .|:.|||:|||.|||.             .|.....:....||.|          |:|.|| ..|
Frog   601 YLVPFLKRSLPALRQL-------------TPDAAAFIQQSQQQQP----------PTQATT-ALT 641

  Fly   583 QVRMITPNALGTPRPTIGHTTISKQPPNIRLPTAPRLVNTGGIRTQIPSLQVPGQANIVQIRGPQ 647
            .| |::.:...|...|....|.:.|.|.|.|             ||....: |||...:.|:
Frog   642 AV-MLSGSVQRTAGKTTATVTNTLQQPVISL-------------TQTAQSK-PGQPTPLVIQ--- 688

  Fly   648 HAQLQRTGSVQIRATTRPPNSVPTANKLTAVKVGQTQIKAITPSLHPPSLAAISGGPPPTPTLSV 712
              |..:.|:|     .|||:...|...:.|::....:|...|..|.
Frog   689 --QAHKAGAV-----VRPPHVTLTQTPMVALRQPPNRIMLTTQQLQ------------------- 727

  Fly   713 LSTLNSASTTTLPIPSLPTVHLPPEALRAREQMQNSLNHNSNHFDAKLVEIKAPSLHPPHMERIN 777
            |:.|.:.:..|:|:.....|.
Frog   728 LNPLQTGAMQTVPMAKQALVQ-------------------------------------------- 748

  Fly   778 ASLTPIGAKTMARPPPAINKAIGKKKRDAMEMDAKLNTSSGGAASAANSFFQQSSMSSMYGDDDI 842
                  |||||:        ||                 |..||:|..:..::....|...||||
Frog   749 ------GAKTMS--------AI-----------------SAQAAAAQKNKLKEPGGGSFRDDDDI 782

  Fly   843 NDVAAMGGVNLAEESQRILGC-TENIGTQIRSCKDEVFLNLPS-LQARIRAITSEAGLDEPSQDV 905
            ||||:|.||||:|||.|||.. :|.:||..||||||.|| ||: ||.||..|..:.|:.|..|||
Frog   783 NDVASMAGVNLSEESARILATNSELVGTLTRSCKDETFL-LPALLQRRILEIGKKHGITEIHQDV 846

  Fly   906 AVLISHACQERLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELER 970
            ...:|||.|:||:|||||::..|:.:....|.|.|||...|||.|:||.|:||:.|::|.:|.||
Frog   847 VSYVSHATQQRLQNIVEKISETAQQKNISHKDDDRYEQTSDVRTQLKFFEQLDQIEKQRKDEQER 911

  Fly   971 EMLLRAAKSRSRVEDPEQAKMKARAKEMQRAEMEELRQRDANLTALQAIGPRKKLKLDGETVSSG 1035
            |:|:||||||||.|||||.::|.:|||||:.|:.::||||||||||.|||||||.|::.....||
Frog   912 EILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVESPGPGSG 976

  Fly  1036 AGSSGGGVLSSSGSA----PTTLRPRIKRVNLRDMLFYMEQEREFCRSSMLFKTYLK 1088
            :.||.....::|.||    ....|.||.||||||::..:|.|||...|.:|:|.:||
Frog   977 SESSSTSTATASSSAGGGSRQFTRQRITRVNLRDLILCLESERETSHSLLLYKAFLK 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf4	NP_001137958.1	TAFH	460..550	CDD:197785	35/91 (38%)
Taf4	NP_001137958.1	TAF4	842..1084	CDD:283017	132/247 (53%)
taf4	NP_001072285.1	PHA03247	<323..496	CDD:223021	46/187 (25%)
		TAFH	541..619	CDD:369407	34/90 (38%)
		TAF4	782..1030	CDD:368350	132/248 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	231	1.000	Domainoid score	I2388
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	198	1.000	Inparanoid score	I3680
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322413at33208
OrthoFinder	1	1.000	-	-		FOG0001841
OrthoInspector	1	1.000	-	-		otm49299
Panther	1	1.100	-	-	O	PTHR15138
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4777
SonicParanoid	1	1.000	-	-		X2359
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190