Protein Alignment Taf4 and Taf4b

DIOPT Version :10

• Sequence 1: NP_001137958.1
• Gene: Taf4 / 39765
• FlyBaseID: FBgn0010280
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: NP_001093919.1
• Gene: Taf4b / 72504
• MGIID: 2152345
• Length: 855
• Species: Mus musculus
• Alignment Length: 1065
• Identity: 301/1065 - (28%)
• Similarity: 455/1065 - (42%)
• Gaps: 291/1065 - (27%)

  Fly   101 VTLPAG----LVSSAPAGIVTMTKT----INQAGQPL-LNSMLPAGVVVGMRQQAPSQQQ----- 151
            :|.|||    :|||| :|.|||...    :...|.|: |..:..|.|.|.:...||....
Mouse     5 LTEPAGAAAPVVSSA-SGAVTMAPVAALPVRVEGTPVALGPVTKAPVSVCVESVAPQPLPAPVGT 68

  Fly   152 --QKNVPTNPLSRVVINSHMAGVRPQSPSI-TLST--LNTGQTPA--------LLVKTDNGFQLL 203
              .|.||...|.:      :...|..:|.| |:.|  ..|.|.||        :|:|:::| ||:
Mouse    69 LVTKVVPVTALPK------LGSPRLPAPQIVTVKTPGTTTIQLPANLQLPPGTVLIKSNSG-QLM 126

  Fly   204 RVGTTTGPPTVTQTITNTSNNSNTTSTTNHPTTTQ-IRLQTVPAAAVSRYQQQQQHQQQSQQQQQ 267
            .|       :..|.:|.....||.|.....|..|| :::.|||                   ...
Mouse   127 LV-------SPQQAVTGAKTTSNITPRPAVPANTQTVKICTVP-------------------NSS 165

  Fly   268 SQQQQHATSTTASTSIALRKTIVRTSSTVPSSNNNNNSINATTNTTTTTTTNNNNKPATNQQQQQ 332
            ||..:..|       :|..|.:.:..:||                .||.::.::.:|
Mouse   166 SQLMKKVT-------VAPVKNLTQIGTTV----------------ATTASSTSSGQP-------- 199

  Fly   333 QKLQQQQHLKAQQQQKQQQASAAAAAAAAAANVAATIKIKQNSMTNTTATSNIIVNSVASSGYAN 397
                                         .|..::.|.:....:.||       |:::.||....
Mouse   200 -----------------------------VALPSSVITVTPAKLVNT-------VSTLKSSSLGV 228

  Fly   398 SSQPPHLTQLNAQAPQLPQITQIQTIPAQQSQQQQVNNVSSAGGTATAVSSTTAATTTQQGNTKE 462
            .|.|.:..:|.|:                                 |:|::.||...|...|.|
Mouse   229 LSTPSNDARLKAE---------------------------------TSVAAQTALPPTVLENVK- 259

  Fly   463 KCRKFLANLIELS---TREPKPVEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLK 524
            ||:.||:.||:|:   ::.|: :.:||:.|:::|::|.:|.|||..:|...|.::|||.|:.|||
Mouse   260 KCKNFLSMLIKLACSGSQSPE-MGQNVKRLVEQLLDAEIEAEEFTRKLYIELKSAPQPHLVPFLK 323

  Fly   525 KSLPLLRQALYTKELVIEGIKPPPQHVLGLAGLSQQLPKIQAQIRPIGPSQTTTIGQTQVRMITP 589
            ||:..|||.|...:..||..                       ::.:.       |...:...|.
Mouse   324 KSVVALRQLLPNSQSFIENC-----------------------VKEVS-------GDVVISSCTM 358

  Fly   590 NALGTPRPTIGHTTISKQPPNIRLPTAPRLVNTGGIRTQIPSLQVPGQAN--IVQIR--GPQHAQ 650
            ....:|..|   :|:|  |..:...||||   |..::..:..|..||.||  :|.:.  .|..|.
Mouse   359 TTATSPVVT---STVS--PVLVSGATAPR---TLSVQQTLNPLAGPGVANTGVVTLHSVAPAAAT 415

  Fly   651 LQRTGSVQIRATTRP-PNSVPTANKLTAVKVGQTQIKAITPSLHPPSLAAISGGPPPTPTLSVLS 714
            ...|.:..:..|::| ..|||  |.:.||            ||.|.: ..:||.   ..||::.|
Mouse   416 GGTTAATVLLQTSKPLTTSVP--NTVAAV------------SLQPEN-PVVSGA---AVTLAIPS 462

  Fly   715 -TLNSASTTTLPIPSL-------------------------PTVHLPPEA----------LRARE 743
             |...||.|.|.:||.                         |:..||..|          |..::
Mouse   463 ATFGEASATPLCLPSAKPAITSAGTKADKPAIGTPVQIVTQPSTLLPQAAGIPQTAKVKQLVVQQ 527

  Fly   744 QMQNSLNHNSNHFDAKLVEIKAPSLHPPHMERINASLTPIGA--KTMARPPPAINKAIGKKKRDA 806
            ...:|:||           :.:.|...|...:.....||:.|  .|...||.:|.|.|.......
Mouse   528 PSGSSVNH-----------VTSISHSSPLSTQNCGQKTPVNAVMPTSKFPPSSIIKQITLPGNKL 581

  Fly   807 MEMDAKLNTSSGGAASAANSFFQQSSMSSMYGDDDINDVAAMGGVNLAEESQRILGC-TENIGTQ 870
            :.:.|:       .:|..::..:::..:...|:||||||..|..|||.||:..||.. ::.:||.
Mouse   582 LSLQAQ-------RSSIQSNKIKENGPTCFRGEDDINDVTFMAEVNLDEENACILAAHSDFVGTL 639

  Fly   871 IRSCKDEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQERLKNIVEKLAVIAEHRIDVI 935
            |:|||:|.||.:.:||.||..|..:..:.|.:.|...|||||.||||:.::|||..||:||:.:.
Mouse   640 IQSCKEEPFLVIGALQKRILDIGKKHDITELNSDAVNLISHATQERLRGLLEKLTTIAQHRMTIY 704

  Fly   936 KLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELEREMLLRAAKSRSRVEDPEQAKMKARAKEMQR 1000
            |....|..:.|.|.|:||||:||:.|::|.:..||||||:||||||..|||||.::|.:|||:|:
Mouse   705 KGSENYILSTDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQ 769

  Fly  1001 AEMEELRQRDANLTALQAIGPRKKLKLD--GETVSSGAGSSGGGVLSSSGSAPTTLRPRIKRVNL 1063
            .|:.:::.||||||||.|||||||..|:  .|:......:||    :||.:|....||||.|:.|
Mouse   770 LELAQIQYRDANLTALAAIGPRKKRPLESGNESFKDNPSTSG----TSSLTATKPFRPRITRICL 830

  Fly  1064 RDMLFYMEQEREFCRSSMLFKTYLK 1088
            ||::|.||||||...|..|:...||
Mouse   831 RDLIFCMEQEREMKYSRALYLALLK 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Taf4	NP_001137958.1	TAFH	460..550	CDD:197785	35/92 (38%)
		PHA03378	<500..>742	CDD:223065	69/282 (24%)
		TAF4	842..1084	CDD:461598	119/244 (49%)
Taf4b	NP_001093919.1	PRK12323	<2..>91	CDD:481241	25/92 (27%)
		Sufficient for interaction with ZNF628. /evidence=ECO:0000269|PubMed:31932482	99..240		41/234 (18%)
		TAFH	257..344	CDD:462195	36/111 (32%)
		Required for interaction with P65/RELA. /evidence=ECO:0000250|UniProtKB:Q92750	504..526		5/21 (24%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q92750	509..549		8/50 (16%)
		TAF4	610..850	CDD:461598	118/243 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	793..817		7/27 (26%)
		Required for interaction with TAF12. /evidence=ECO:0000250|UniProtKB:Q92750	823..855		16/31 (52%)