DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf4 and TAF4B

DIOPT Version :9

Sequence 1:	NP_001137958.1	Gene:	Taf4 / 39765	FlyBaseID:	FBgn0010280	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001280654.1	Gene:	TAF4B / 6875	HGNCID:	11538	Length:	867	Species:	Homo sapiens

Alignment Length:	1087	Identity:	303/1087 - (27%)
Similarity:	442/1087 - (40%)	Gaps:	321/1087 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 LPAGL---VSSAPAGIVTMTKTINQAGQPLLNSMLPAG----------VVVGMRQQAPSQQQQKN 154
            :||||   ..:||...|:.:.|:         :|.|||          |.:|...:||.....:.
Human     1 MPAGLTEPAGAAPPAAVSASGTV---------TMAPAGALPVRVESTPVALGAVTKAPVSVCVEP 56

  Fly   155 VPTNPLSRVV---------------INSHMAGVRPQSPSITLSTLNTGQTPA--------LLVKT 196
            ..:.||...|               ::|......||..::......|.|.||        :|:|:
Human    57 TASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGTVLIKS 121

  Fly   197 DNGFQLLRVGTTTGPPTVTQTITNTSNNSNTTSTTNHPTTTQ-IRLQTVPAAAVSRYQQQQQHQQ 260
            ::|..:|     ..|   .||:|.....||.||....|...| :::.|||
Human   122 NSGPLML-----VSP---QQTVTRAETTSNITSRPAVPANPQTVKICTVP--------------- 163

  Fly   261 QSQQQQQSQQQQHATSTTASTSIALRKTIVRTSSTVPSSNNNNNSINATTNTTTTTTTNNNNKPA 325
                 ..|.|.....:.|....:|...|.|.|:...|||   ..|:...|:..|.|.    .||
Human   164 -----NSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSS---VQSVAVPTSVVTVTP----GKP- 215

  Fly   326 TNQQQQQQKLQQQQHLKAQQQQKQQQASAAAAAAAAAANVAATIKIKQNSMTNTTATSNIIVNSV 390
                                                 .|...|:|                .:|:
Human   216 -------------------------------------LNTVTTLK----------------PSSL 227

  Fly   391 ASSGYANSSQPPHLTQLNAQAPQLPQITQIQTIPAQQSQQQQVNNVSSAGGTATAVSSTTAATTT 455
            .:|  :..|..|:|...|:.|.|:                    |:|                .|
Human   228 GAS--STPSNEPNLKAENSAAVQI--------------------NLS----------------PT 254

  Fly   456 QQGNTKEKCRKFLANLIELS---TREPKPVEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQP 517
            ...|.| ||:.|||.||:|:   ::.|: :.:||:.|:::|::|.:|.|||..:|...|.:||||
Human   255 MLENVK-KCKNFLAMLIKLACSGSQSPE-MGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQP 317

  Fly   518 CLIGFLKKSLPLLRQALYTKELVIEGIKPPPQHVLGLAGLSQQLPKIQAQIRPIGPSQTTTIGQT 582
            .|:.|||||:..|||.                           ||..|:.|:       ..:.||
Human   318 HLVPFLKKSVVALRQL---------------------------LPNSQSFIQ-------QCVQQT 348

  Fly   583 QVRMI--TPNALGTPRPTIGHTTISKQPPN---IRLPTAPRLVNTGGIRTQIP-SLQVPGQANIV 641
            ...|:  |.....|..|.:..|..|.|...   :...||||.|:   ::|..| :..|..:|.:|
Human   349 SSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVS---VQTLNPLAGPVGAKAGVV 410

  Fly   642 QIR--GPQHAQLQRTGSVQIRATTRP-PNSVPTANKLTAVK-------VGQTQIKAITPSLHPPS 696
            .:.  ||..|....|....:..|::| ..||  ||.:|.|.       |..|   |:|.||...:
Human   411 TLHSVGPTAATGGTTAGTGLLQTSKPLVTSV--ANTVTTVSLQPEKPVVSGT---AVTLSLPAVT 470

  Fly   697 LAAISGGPPPTPTLSVLSTLNSASTTT------------LPIPSLPTVHLP---PEALRAR---- 742
            ....||.....|  ||...::||.||:            |..|. |.:..|   |:|::.:
Human   471 FGETSGAAICLP--SVKPVVSSAGTTSDKPVIGTPVQIKLAQPG-PVLSQPAGIPQAVQVKQLFS 532

  Fly   743 ------------EQMQNSLNHNSNHFDAKLVEIKAPSLHPPHMERINASLTPIGAKTM------- 788
                        |:...:::|:|                       ..::...|.|||
Human   533 LFQVVQQPSGGNEKQVTTISHSS-----------------------TLTIQKCGQKTMPVNTIIP 574

  Fly   789 --ARPPPAINKAIGKKKRDAMEMDAKLNTSSGGAASAANSFFQQSSMSSMYGDDDINDVAAMGGV 851
              ..||.:|.|.|.......:.:.         |:....:..:::..|....:||||||.:|.||
Human   575 TSQFPPASILKQITLPGNKILSLQ---------ASPTQKNRIKENVTSCFRDEDDINDVTSMAGV 630

  Fly   852 NLAEESQRILGC-TENIGTQIRSCKDEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQE 915
            ||.||:..||.. :|.:||.|:|||||.||.:.:||.||..|..:..:.|.:.|...|||.|.||
Human   631 NLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVNLISQATQE 695

  Fly   916 RLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELEREMLLRAAKSR 980
            ||:.::|||..||:||:...|....|....|.|.|:||||:||:.|::|.:..||||||:|||||
Human   696 RLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSR 760

  Fly   981 SRVEDPEQAKMKARAKEMQRAEMEELRQRDANLTALQAIGPRKKLKLDGETVSSGAGSSGGGVLS 1045
            |..|||||.::|.:|||:|:.|:.:::.||||||||.|||||||..|:     ||.......:|:
Human   761 SNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRKKRPLE-----SGIEGLKDNLLA 820

  Fly  1046 SSGSAPTTL----RPRIKRVNLRDMLFYMEQEREFCRSSMLFKTYLK 1088
            |..|:.|..    ||||.|:.|||::|.||||||...|..|:...||
Human   821 SGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRALYLALLK 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf4	NP_001137958.1	TAFH	460..550	CDD:197785	34/92 (37%)
Taf4	NP_001137958.1	TAF4	842..1084	CDD:283017	121/246 (49%)
TAF4B	NP_001280654.1	Sufficient for interaction with ZNF628. /evidence=ECO:0000250\|UniProtKB:G5E8Z2	100..241		45/231 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..239		6/37 (16%)
		TAFH	258..346	CDD:284862	39/123 (32%)
		TAF4	621..862	CDD:283017	120/245 (49%)
		Required for interaction with TAF12. /evidence=ECO:0000269\|PubMed:15601843	835..867		16/31 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152227
Domainoid	1	1.000	236	1.000	Domainoid score	I2351
eggNOG	1	0.900	-	-		E1_KOG2341
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	270	1.000	Inparanoid score	I3013
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46296
OrthoDB	1	1.010	-	-		D322413at33208
OrthoFinder	1	1.000	-	-		FOG0001841
OrthoInspector	1	1.000	-	-		otm42069
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4777
SonicParanoid	1	1.000	-	-		X2359
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.900