DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf4 and Taf4

DIOPT Version :9

Sequence 1:	NP_001137958.1	Gene:	Taf4 / 39765	FlyBaseID:	FBgn0010280	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	NP_001074561.1	Gene:	Taf4 / 228980	MGIID:	2152346	Length:	1042	Species:	Mus musculus

Alignment Length:	1004	Identity:	293/1004 - (29%)
Similarity:	392/1004 - (39%)	Gaps:	298/1004 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 AVTLPAGLVSSAPAGIVTMTKTINQAGQPLLNSML-------PAGVVVGMRQQAPSQQQQKNVPT 157
            |....||:.....||.|.:        .|.:...|       |||:..|.....||
Mouse   322 AAAAAAGVAGGGAAGSVLL--------GPAMPGALPGPAPGTPAGLAKGAAAATPS--------- 369

  Fly   158 NPLSRVVINSHMAGVRPQSPSITLSTLNTGQTPALLVKTDNGFQLLRVGTTTGPPTVTQTITNTS 222
                           .|::|:.|...:....||.:|.                 |.:.|...|.:
Mouse   370 ---------------LPRTPAATTGAIRATLTPTVLA-----------------PRLPQPPQNPT 402

  Fly   223 NNSNTTSTTNHPTTTQIRLQTVPAAAVSRYQQQQQHQQQSQQQQQSQQQQHATSTTASTSIALRK 287
            |..|              .|..|...:.|.:..|  .....||..:|.|.||.:...||...
Mouse   403 NIQN--------------FQLPPGMVLVRSENGQ--LLMIPQQALAQMQAHAQAQPQSTMAP--- 448

  Fly   288 TIVRTSSTVPSSNNNNNSINATTNTTTTTTTNNNNKPATNQQQQQQKLQQQQHLKAQQQQKQQQA 352
                                               :|||.......::...|
Mouse   449 -----------------------------------RPATPTGAPPVQISTVQ------------- 465

  Fly   353 SAAAAAAAAAANVAATIKIKQNSMTNTTATSNIIVNSVASSGYANSSQPPHLTQLNAQAPQLPQI 417
              |......|..|..|..|||.|...||      |....:...:...||..:...:||...|...
Mouse   466 --APGTPIIARQVTPTTIIKQVSQAQTT------VQPTTTLQRSPGVQPQLVLGGSAQPASLGTA 522

  Fly   418 TQIQTIPAQQSQQQQVNNVSSAGGTATAVSSTTAATTTQQGNTKEKCRKFLANLIELSTREPKPV 482
            |.:||...|:              |....|:|:.|.|....|.| ||:.||:.||:|::...:..
Mouse   523 TAVQTGTPQR--------------TVPGASTTSTAATETMENVK-KCKSFLSTLIKLASSGKQST 572

  Fly   483 E--KNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKKSLPLLRQALYTKELVIEGIK 545
            |  .||:.|:|.|::..:|.|:|..||.|.||:||||.|:.|||:|||.|||.
Mouse   573 ETAANVKDLVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQL------------ 625

  Fly   546 PPPQHVLGLAGLSQQLPKIQAQIRPIGPSQTTTIGQTQVRMITPNALGTPRPTIGHTTISKQPPN 610
             .|.....:....||.|          |:...|...|.| :::.:...|...|....|.:.|||.
Mouse   626 -TPDSAAFIQQSQQQQP----------PASQATTALTAV-VLSSSVQRTAGKTAASVTSALQPPV 678

  Fly   611 IRLPTAPRLVNTGGIRTQIPSLQVPGQANIVQIRGPQHAQLQRTGSVQIRATTRPPNSVPTANKL 675
            |.| |.|..|..|        .|.|....::|       |..:.|     |..|||....|...:
Mouse   679 ISL-TQPTQVGVG--------KQAPPTPLVIQ-------QPPKPG-----ALIRPPQVTLTQTPM 722

  Fly   676 TAVKVGQTQIKAITPSLHPPSLAAISGGPPPTPTLSVLSTLNSASTTTLPIPSL-PTVHLPPEAL 739
            .|::....:|...||.                     ...||...    |:|.: ||| ||
Mouse   723 VALRQPHNRIMLTTPQ---------------------QIQLNQLQ----PVPVVKPTV-LP---- 757

  Fly   740 RAREQMQNSLNHNSNHFDAKLVEIKAPSLHPPHMERINASLTPIGAKTMARPPPAINKAIGKKKR 804
                                                        |.|.
Mouse   758 --------------------------------------------GTKA----------------- 761

  Fly   805 DAMEMDAKLNTSSGGAASAANSFFQQSSMSSMYGDDDINDVAAMGGVNLAEESQRILGC-TENIG 868
                    |:|.|..||:|..:..::....|...||||||||:|.||||:|||.|||.. :|.:|
Mouse   762 --------LSTVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAGVNLSEESARILATNSELVG 818

  Fly   869 TQIRSCKDEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQERLKNIVEKLAVIAEHRID 933
            |..|||||:.||....||.||..|..:.|:.|...||...:|||.|:||:|:|||::..|:.:..
Mouse   819 TLTRSCKDDTFLLPAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNF 883

  Fly   934 VIKLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELEREMLLRAAKSRSRVEDPEQAKMKARAKEM 998
            ..|.|.|||.|.|||.|:||.|:||:.|::|.:|.|||:|:||||||||.|||||.::|.:||||
Mouse   884 SYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEM 948

  Fly   999 QRAEMEELRQRDANLTALQAIGPRKKLKLDGETVSSGAGSSGGGVLSSSGSAPTT----LRPRIK 1059
            |:.|:.::||||||||||.|||||||.|:|.....|||..||.|.....||...|    .|.||.
Mouse   949 QQQELAQMRQRDANLTALAAIGPRKKRKVDCTGPGSGAEGSGPGAAVPGGSGVGTPRQFTRQRIT 1013

  Fly  1060 RVNLRDMLFYMEQEREFCRSSMLFKTYLK 1088
            ||||||::|.:|.|||...|.:|:|.:||
Mouse  1014 RVNLRDLIFCLENERETSHSLLLYKAFLK 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf4	NP_001137958.1	TAFH	460..550	CDD:197785	37/91 (41%)
Taf4	NP_001137958.1	TAF4	842..1084	CDD:283017	132/246 (54%)
Taf4	NP_001074561.1	TAFH	550..633	CDD:284862	15/82 (18%)
Taf4	NP_001074561.1	TAF4	791..1039	CDD:283017	43/248 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842296
Domainoid	1	1.000	237	1.000	Domainoid score	I2315
eggNOG	1	0.900	-	-		E1_KOG2341
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001841
OrthoInspector	1	1.000	-	-		otm44123
orthoMCL	1	0.900	-	-		OOG6_105779
Panther	1	1.100	-	-	O	PTHR15138
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2359
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.700