DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Taf4 and taf4b

DIOPT Version :9

Sequence 1:	NP_001137958.1	Gene:	Taf4 / 39765	FlyBaseID:	FBgn0010280	Length:	1088	Species:	Drosophila melanogaster
Sequence 2:	XP_017208212.2	Gene:	taf4b / 100150678	ZFINID:	ZDB-GENE-070424-105	Length:	833	Species:	Danio rerio

Alignment Length:	1087	Identity:	278/1087 - (25%)
Similarity:	418/1087 - (38%)	Gaps:	339/1087 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QSQQQQQQQQQTQSV-GATQTQ-----------TLVIKSNHHAVTL--------PAGLVSSAPAG 114
            ::|.:::.:.||.:: ..::|.           .::...|..:|:|        .||..::||.|
Zfish    16 RTQTEKKNEAQTNNIENLSETSDKKREVTDLNANVITNRNPDSVSLNEKADPKTEAGSSNAAPQG 80

  Fly   115 IVTMTKTINQAGQPLLNSMLPAG------VVVGMRQQAPSQQQQKNVPTNPLSRVVINSHMAGVR 173
            .||::         ||.|...|.      |:||     |:|.:.    |.|   ||:.:.:
Zfish    81 PVTVS---------LLTSSTSASSEAAPKVMVG-----PAQIKS----TTP---VVVGARV---- 120

  Fly   174 PQSPSITLSTLNTGQTPALLVKTDNGFQLLRVGTTTGPPTVT---------QTITNTSNNSNTTS 229
                 :|.|....|.|...||.     |..||......|.||         .|:...|..|....
Zfish   121 -----VTSSVQGPGTTSLALVP-----QPGRVSVAISQPRVTTLTTAKGPVMTLPRISTPSQGVP 175

  Fly   230 TTNHPTTTQIRLQT---VPAAAVSRYQQQQQHQQQSQQQQQSQQQQHATSTTASTSIALRKTIVR 291
            .|..|.|..::|..   ||...|.......|....|||.....|.....:.:|:.|..:|.
Zfish   176 MTRAPQTVPLQLPANFQVPQGMVLIRSDSGQLMLVSQQALAQAQGMLPKAASANASAIVRP---- 236

  Fly   292 TSSTVPSSNNNNNSINATTNTT-----------TTTTTNNNNKPATNQQQQQQKLQQQQHLKAQQ 345
                 |||       .||.|||           .:.|.|....|......|:........:..
Zfish   237 -----PSS-------QATVNTTPIIRVSLPPTSASATANIKLNPTVGTAVQKPAAATGTAVFT-- 287

  Fly   346 QQKQQQASAAAAAAAAAANVAATIK---------IKQNSMT---NTTATSNIIVNSVASSGYANS 398
                ...||....:..||.|...::         ||.:.||   :|..|.|...|||.::...|:
Zfish   288 ----PSCSAGTTISKPAAVVCTAVRKPSSTMGPVIKASQMTPNSSTPGTFNQRTNSVTATTVINT 348

  Fly   399 SQPPHLTQLNAQAPQLPQITQIQTIPAQQSQQQQVNNVSSAGGTATAVSSTTAATTTQQGNTKEK 463
            |....:.:..               |:.||...:|.:.:....::|..|||....|.:.....:|
Zfish   349 SAGKSVGKGG---------------PSIQSNAPRVVSPNVPPRSSTNTSSTPVTVTAETLENVKK 398

  Fly   464 CRKFLANLIELS---TREPKPVEKNVRTLIQELVNANVEPEEFCDRLERLLNASPQPCLIGFLKK 525
            |:.||..|::|:   ||... :.:|||.|::.|::..:|.|||.::|...|.:||||.|:.|||:
Zfish   399 CKNFLVTLMKLASSGTRSAN-MAQNVRALVKGLLDGKLEAEEFTEKLYMELKSSPQPYLVPFLKR 462

  Fly   526 SLPLLRQALYTKELVIEGIKPPPQHVLGLAGLSQQLPKIQAQIRPIGPSQTTTIGQTQVRMITPN 590
            |||.:||.....:|.|:                        |...:.||.:.....|..:
Zfish   463 SLPAVRQLTPNSQLFIQ------------------------QCDHLKPSDSALTKSTNQK----- 498

  Fly   591 ALGTPRPTIGHTTISKQPPNIRLPTAPRLVNTGGIRTQIPSLQVPGQANIVQIRGPQHAQLQRTG 655
                     ...::|....|.:....|:||.|.|:..:.|.:.:..|:
Zfish   499 ---------ASASVSSSLKNSQPTRTPQLVQTTGVVVKQPQVGLAAQS----------------- 537

  Fly   656 SVQIRATTRPPNSVPTANKLTAVKVGQTQIKAITPSLHPPSLAAISGGPPPTPTLSVLSTLNSAS 720
                                      |||.|.:.......|..|:           |..::..||
Zfish   538 --------------------------QTQSKQMVIQTSTHSTGAV-----------VRQSILQAS 565

  Fly   721 TTTLPIPSLPTVHLPPEALRAREQMQNSLNHNSNHFDAKLVEIKAPSLHPPHMERINASLTPIGA 785
            .|....|:||
Zfish   566 KTHFSQPTLP------------------------------------------------------- 575

  Fly   786 KTMARPPPAINKAIGKKKRDAMEMDAKLNTSSGGAASAANSFFQQSSMSSMYGDDDINDVAAMGG 850
                                                :.|:| |:.|:..|...||||||||:|.|
Zfish   576 ------------------------------------AQAHS-FKDSTSGSFRDDDDINDVASMAG 603

  Fly   851 VNLAEESQRILGC-TENIGTQIRSCKDEVFLNLPSLQARIRAITSEAGLDEPSQDVAVLISHACQ 914
            |||:||:.|||.. :|.:|:.||||::|.||...:||.|:..|....|:.|...||..|||.|.|
Zfish   604 VNLSEENARILASGSELVGSVIRSCQEEPFLFPSALQTRVLHIGGSLGVTEVCPDVLELISLATQ 668

  Fly   915 ERLKNIVEKLAVIAEHRIDVIKLDPRYEPAKDVRGQIKFLEELDKAEQKRHEELEREMLLRAAKS 979
            |||::::||:..:|:||....:.|.||....|.|.|:||||:|::.|:::.||.|||.|||.|:|
Zfish   669 ERLRDLLEKITAVAQHRQISYRDDWRYTQTNDTRSQLKFLEQLERLEKQKREEEERETLLRIARS 733

  Fly   980 RSRVEDPEQAKMKARAKEMQRAEMEELRQRDANLTALQAIGPRKKLKLDGETVSSGAGSSGGGVL 1044
            ||..|||||.::|.||||||:.|:.::..|||||.||.|:|||||..|:    :.|.|::  .:|
Zfish   734 RSNSEDPEQQRLKQRAKEMQQLELAQMEHRDANLAALAALGPRKKKPLE----APGLGAN--QLL 792

  Fly  1045 SSSG----SAPTTLRPRIKRVNLRDMLFYMEQEREFCRSSMLFKTYL 1087
            .|.|    .||.       ||.:||:.|||||:..|..:.:|::.:|
Zfish   793 GSHGHFASRAPV-------RVTMRDLTFYMEQDPTFRHTLVLYRAFL 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Taf4	NP_001137958.1	TAFH	460..550	CDD:197785	34/92 (37%)
Taf4	NP_001137958.1	TAF4	842..1084	CDD:283017	114/246 (46%)
taf4b	XP_017208212.2	Atrophin-1	<136..391	CDD:331285	63/296 (21%)
		TAFH	395..481	CDD:311467	34/110 (31%)
		TAF4	595..830	CDD:310095	114/247 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586694
Domainoid	1	1.000	78	1.000	Domainoid score	I8699
eggNOG	1	0.900	-	-		E1_KOG2341
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2693
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D322413at33208
OrthoFinder	1	1.000	-	-		FOG0001841
OrthoInspector	1	1.000	-	-		otm25787
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15138
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4777
SonicParanoid	1	1.000	-	-		X2359
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.980