DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and adarb1a

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_571685.2	Gene:	adarb1a / 58134	ZFINID:	ZDB-GENE-000627-2	Length:	720	Species:	Danio rerio

Alignment Length:	504	Identity:	99/504 - (19%)
Similarity:	146/504 - (28%)	Gaps:	186/504 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GTQY----NTGQVSYPAVTNATYANAAAYQ-----------NAAVAA----GQGGYGGAAGAGAG 58
            |.||    .||.|..|........|...::           |||..|    .|......|....|
Zfish   108 GLQYKLLSQTGPVHAPVFVMTVEVNGQLFEGSGPTKKKAKLNAAEKALRSFVQFPNASEAHLAMG 172

  Fly    59 ATSGPGAGGYGGYGDYRSAMQYDATKTFYQQSPASYNASGSTASVSKTHYSAPPVKNQVKGKMDK 123
            .|....|.......|:.. |.::..:|........|.:.||..|:........||..:.|.:
Zfish   173 RTLTVNADFTSDQADFPD-MLFNGFETPVPPDDPFYLSLGSNGSLCSLKEYRLPVTLKYKNR--- 233

  Fly   124 SNGGPKPP------SSAPPAGNNYSGYDTAL----------YNAASMYVA---QQHQGN------ 163
                |.||      .:|||.|   ||.:..:          |.    :||   :.|..|
Zfish   234 ----PHPPLPLAPALTAPPTG---SGKNAVMILNELRPGLKYE----FVAESGESHAKNFIMSVT 287

  Fly   164 -PNQKPNGGANNWYQRKMGATIPGATAIRGM-------RPKAPPRPQ---QLHYCEVCKISCAGP 217
             ..||..|...|   :|:........|:.|:       .|...|.|:   |||.          |
Zfish   288 VDTQKFQGSGRN---KKLAKARAAQAALSGLFNMQLDQTPSRQPIPREGLQLHL----------P 339

  Fly   218 QTYREHLEGQKHKKREASLKMSASANSATQNRGNNYHCELCDVTCTGTDAYAA-HVRGAKHQKVV 281
            |...:.:      .|....|.|                ||       ||.::: |.|    :||:
Zfish   340 QVLADAV------SRLVVDKFS----------------EL-------TDNFSSPHAR----RKVL 371

  Fly   282 KLHQKLGKPIPSEEPKKMGKINFVPAAAGGAGVAKTEGGANESDAAGDLDDNLDDSLGENTDNIK 346
                                          |||..|.|           .|.:|..:...|...|
Zfish   372 ------------------------------AGVVMTTG-----------KDVMDAQVICVTTGTK 395

  Fly   347 PVGGEYIEE----VKDEEGKILSFNCKLCDCKFND-----PNAKEMHMKG-----RRHRLQYKRK 397
            .:.|||:.:    :.|...:|:: ...|....:|.     .::.|.|.|.     ..|..:.|..
Zfish   396 CINGEYMSDRGLALNDCHAEIIA-RRSLIRYLYNQLEYFLSDSTEEHEKSIFRWCSEHGYRLKDD 459

  Fly   398 VQPDLVVDFKPTPRQRRLAEARANRAMMSSHRGGDDHDGGYWEEQRNRQ 446
            :|..|.:...|      ..:||    :.|.|..|.:..|   :...||:
Zfish   460 IQFHLYISTSP------CGDAR----IFSPHEAGAEDQG---DRHPNRK 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	4/30 (13%)
		C2H2 Zn finger	207..229	CDD:275371	2/21 (10%)
		ZnF_U1	252..284	CDD:197732	8/32 (25%)
		C2H2 Zn finger	255..277	CDD:275371	6/22 (27%)
		ZnF_U1	368..396	CDD:197732	6/37 (16%)
		C2H2 Zn finger	368..390	CDD:275371	5/31 (16%)
		DZF	577..829	CDD:128842
adarb1a	NP_571685.2	DSRM	95..157	CDD:214634	12/48 (25%)
		DSRM	254..303	CDD:238007	10/55 (18%)
		ADEAMc	341..717	CDD:214718	43/243 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930