DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zn72D and zfr2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_005161660.1	Gene:	zfr2 / 567465	ZFINID:	ZDB-GENE-070705-184	Length:	1004	Species:	Danio rerio

Alignment Length:	1048	Identity:	404/1048 - (38%)
Similarity:	532/1048 - (50%)	Gaps:	233/1048 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNNYAGFNY-----GGTQYNT-GQVSYPAVTNATYANAAAYQNAAVAAGQGGYGGAAGAGAGA 59
            ||.:||.||.:     .|.||:| ...:|...|..:| |.......|.|.........|.....|
Zfish     2 MAASNYYGFTHAAAAAAGPQYSTQPPPAYSHPTTGSY-NVQPAPGVAHAVTASYPAPTAQPARPA 65

  Fly    60 TSGP-------GAGGYG--------------------------GYGDYRSAMQYDATKTFYQ--- 88
            .:.|       .|..||                          .||.......|: .|.::|
Zfish    66 VTAPYPTYQPHPAPNYGYRQPETTPQPTTTPQTYQVLTEPENYTYGRPPPVSSYE-NKQYFQTSI 129

  Fly    89 ---QSPA--SYNASG--STASVSKTHYSAPPVKNQVKGKMDKSNGGPKPP--------------- 131
               |.||  :|..:|  |..|.:.|.|:.|||:.||        ...|||
Zfish   130 APAQRPATEAYFQTGLKSGYSPASTAYNQPPVQRQV--------AALKPPPAVSSVSSSYTIYPT 186

  Fly   132 ------SSAP------------PAGNNYSGYDTALYNAASMYV-------------------AQQ 159
                  |.||            .||.|||.||::.|.:...|.                   .||
Zfish   187 STSVQQSPAPSSSFNSTAATSYSAGLNYSSYDSSGYTSTPSYYQPAQCAPPQAQPQPPLQPPQQQ 251

  Fly   160 HQGNP------NQKPNGGANNWYQRKMGATI--PGATAIRG--------MRPKAPPRPQQLHYCE 208
            .|..|      .|.|...||:.:....|:::  |..::.|.        .:||.||:..|||||:
Zfish   252 PQPQPPPPQQTQQPPKQLANSSWSNSGGSSVSSPAVSSYRKPAFHQNKIQKPKGPPKQPQLHYCD 316

  Fly   209 VCKISCAGPQTYREHLEGQKHKKREASLKMSASANSATQNRGNNYHCELCDVTCTGTDAYAAHVR 273
            :||||||||||||||||||||||:||:.|..:...:..:.......||||||:|||.||||||:|
Zfish   317 ICKISCAGPQTYREHLEGQKHKKKEAAQKSGSQVTNGPRGVQTQLRCELCDVSCTGADAYAAHIR 381

  Fly   274 GAKHQKVVKLHQKLGKPIPSEE-------PKKMGKINFVPAAAGG----AGVAKTEGGANESDAA 327
            |:|||||||||.||||||||.|       |..|......|||:..    :...|.:..|....||
Zfish   382 GSKHQKVVKLHTKLGKPIPSTEPVLVSSTPAAMTTTTSKPAASTSSTPTSAAQKIQTAAPPKPAA 446

  Fly   328 GDL-----------------------------------------DDNLDDSLGENTDNIKPVGGE 351
            ..:                                         ||...|:.|...| |:|||.:
Zfish   447 APVKKPPPAVSAAKAPAVVSKPSTSTVVKMEEVKPPVVKTDPSSDDEDADATGPQGD-IQPVGHD 510

  Fly   352 YIEEVKDEEGKILSFNCKLCDCKFNDPNAKEMHMKGRRHRLQYKRKVQPDLVVDFKPTPRQRRLA 416
            |:|||::::||::.|:||||:|.|||||||:||:||||||||||:||.|||.|:.||:.|.|:|.
Zfish   511 YVEEVRNDDGKVIRFHCKLCECSFNDPNAKDMHLKGRRHRLQYKKKVNPDLPVEIKPSNRARKLL 575

  Fly   417 EARANRAMMSSHRGGDDHDGGYWEEQRNRQYNEEYDYNNWMSRSFGGAQRFGRMGNGPPPHFG-- 479
            |.:..:....|.......|...|..:.:|:|.|:..:..........|:...||  .|||..|
Zfish   576 EVKLRKQKQKSVLKRQQEDEQRWHMEMSRRYEEDMYWRRMEEEQVYWAEPRRRM--APPPLMGRP 638

  Fly   480 ------MMPGGNVRRPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSD 538
                  ::|   ||||:|.||||.:|:|:.|||.|||||.:||||||:|||||||||.|.|:.
Zfish   639 SIPVPPLLP---VRRPDSPDDRHIMAKHSAIYPVEEELQAVQRIVSHSERALKLVSDTLLEKV-- 698

  Fly   539 AGAANKKDKAEKPSEKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVV 603
            |.|.:.:.:.:|.||...                   |.||||||||.|||||||.||..|:|::
Zfish   699 ACADDDESETDKQSETQS-------------------RTLKGVMRVGILAKGLLLRGDRNVQLIL 744

  Fly   604 LCAEKPTSGLLQRVANVLPDKLKEVAGDTQVNYRVEVNAEEAALIVL---DESVSVKITLTSPLL 665
            |.|.|||..||:.||..||   |::|..::..|.|:|:.|||.:::.   :..:.|.|:||||::
Zfish   745 LAANKPTVSLLKTVAEQLP---KQLATFSEDQYEVQVHPEEANIVIFSSKEPKMQVTISLTSPVM 806

  Fly   666 R-DANPGEAATTDEGEGDSEFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVS 729
            | |..|.....:::...|  .|.|..||..||.|||||||||||.||||||::||:|||||||:.
Zfish   807 REDPVPNMEKVSEKDPPD--LLNRIKCLEYLAALRHAKWFQARANGLQSCVIIIRVLRDLCQRIP 869

  Fly   730 SWQSLPQWSLELLVEKVISSAGFPISPGDCMRRIMEALSSGFLI-NGPGLLDPCEKDPTDALLEL 793
            :|..:|.|::||:|||.||||..|:|||:.:||::|.:::|.|: :||||||||||..||||..:
Zfish   870 TWGKMPNWAMELIVEKAISSASGPLSPGEALRRVLECIATGILLPDGPGLLDPCEKGQTDALGTM 934

  Fly   794 TKQEREDLTVSAQLFLRYIAFRQIYKVLGMEPLPAMKFPMRPWRVNRKRRR-----SSGKAGGAP 853
            :||.|||:|.:||..||.:|||||:|||||..||..|...|    ||||||     ..|:|.|..
Zfish   935 SKQAREDVTANAQHALRLLAFRQIHKVLGMGSLPVSKAAAR----NRKRRRDGSDVGEGEADGKK 995

  Fly   854 GTETESND 861
            ..:.:|||
Zfish   996 DKKDDSND 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	27/30 (90%)
		C2H2 Zn finger	207..229	CDD:275371	19/21 (90%)
		ZnF_U1	252..284	CDD:197732	24/31 (77%)
		C2H2 Zn finger	255..277	CDD:275371	17/21 (81%)
		ZnF_U1	368..396	CDD:197732	23/27 (85%)
		C2H2 Zn finger	368..390	CDD:275371	17/21 (81%)
		DZF	577..829	CDD:128842	137/256 (54%)
zfr2	XP_005161660.1	ZnF_U1	313..342	CDD:197732	25/28 (89%)
		C2H2 Zn finger	315..337	CDD:275371	19/21 (90%)
		ZnF_U1	358..392	CDD:197732	24/33 (73%)
		C2H2 Zn finger	363..385	CDD:275371	17/21 (81%)
		ZnF_U1	524..555	CDD:197732	24/30 (80%)
		C2H2 Zn finger	527..549	CDD:275371	17/21 (81%)
		DZF	718..968	CDD:128842	135/254 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594014
Domainoid	1	1.000	270	1.000	Domainoid score	I1783
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1295
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	1	1.000	-	-		FOG0003979
OrthoInspector	1	1.000	-	-		otm26468
orthoMCL	1	0.900	-	-		OOG6_105636
Panther	1	1.100	-	-	O	PTHR45762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2736
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.760