DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and adarb1b

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_021334693.1	Gene:	adarb1b / 558759	ZFINID:	ZDB-GENE-030219-15	Length:	750	Species:	Danio rerio

Alignment Length:	703	Identity:	125/703 - (17%)
Similarity:	213/703 - (30%)	Gaps:	268/703 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 QKHKKREASLKMSASANSATQNRGNNYHCELCDV-------TCTGTDAYAAHVRGAKHQKVVKLH 284
            ::.:|:.:..|..|.|..|   :|.:....:.||       :|: ||              ||.:
Zfish    24 KRRRKKRSERKGVAVAQQA---QGQSRRLTIMDVDEEENMSSCS-TD--------------VKEN 70

  Fly   285 QKLGKPIPSEEPKKMGKINFVPAAAGGAGVAK-TEGGANESDAAGDLDDNLDDSLGENTDNIKPV 348
            :.|.. :.|:|  ..|.:..:|..:||.|..: .|.|.|                |.:....:|
Zfish    71 RNLDN-VSSKE--GAGLVEQLPNGSGGGGRKRPLEEGNN----------------GHSHSKFRP- 115

  Fly   349 GGEYIEEVKDEEGKILSFNCKLCDCKFNDPNAKEMHMKGRRHRLQYKRKVQ------PDLVVDFK 407
                 ::.|...|.:|             |....|.:...:..||||...|      |..|:..:
Zfish   116 -----KKRKKTPGPVL-------------PKNALMQLNEIKPGLQYKLLSQTGPVHAPVFVMTVE 162

  Fly   408 ----------PTPRQRRL-AEARANRAMMSSHRGGDDHDGGYWEEQRNRQYNEEY--DYNNWMSR 459
                      ||.::.:| |..:|.|:.:......:.|    ....|....|.::  |..::...
Zfish   163 VNGQLFEGSGPTKKKAKLNAAEKALRSFVQFPNASEAH----LAMGRTLTVNTDFTSDQADFPDM 223

  Fly   460 SFGGAQR---------FGRMGNGPPPHFGMMP-----GGN--VRRP--------ESTDDRHAIAR 500
            .|.|.:.         .|..|||.....|..|     |.|  |:.|        .|...::.:..
Zfish   224 LFNGFETPAPPEETFFLGSNGNGSLNPLGEYPVPQAAGTNSLVQAPLPPPSSFASSASGKNPVMI 288

  Fly   501 HAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKDGRDNQIFSFQ 565
            ..|:.|..:.....:...||.:..  ::|..:..|..:....||  |..|........:.:|:.|
Zfish   289 LNELRPGLKYEFVSESGESHAKNF--VMSVTVDSQMFEGSGRNK--KLAKARAAQAALSSLFNMQ 349

  Fly   566 KD---------------------ADNGGNVV------------------RILKGVMRVGYLAKGL 591
            .|                     ||....:|                  ::|.||         :
Zfish   350 LDQTPSRQPIPREGLQLHLPQVLADAVSRLVVDKFSELTDNFTSPHARRKVLAGV---------V 405

  Fly   592 LLHGDNAVELVVLCAEKPTS----------GLLQRVANVLPDKLKEVAGD--------TQVNYRV 638
            :..|.:..:..|:|....|.          ||      .|.|...|:...        .|:.:.:
Zfish   406 MTTGTDVKDAQVICVSTGTKCINGEYMSDRGL------ALNDCHAEIIARRSLIRYLYMQLEHFL 464

  Fly   639 EVNAEEAALIV----------LDESVSVKITLTSPLLRDA---NPGEAATTDEGEGDSEFLPREP 690
            ..|.||....:          |.:||...:.:::....||   :|.||...|:|:       |.|
Zfish   465 SNNKEEHQKSIFMQCEKRGYRLKDSVQFHLYISTSPCGDARIFSPHEAGVEDQGD-------RHP 522

  Fly   691 CLRALADLRH--------------------------------------AKWFQARATGLQSCVM- 716
            ..:|...||.                                      |:|   ...|:|..:|
Zfish   523 NRKARGQLRTKIESGEGTIPVRSSNTIQTWDGVLQGERLLTMSCSDKIARW---NVVGIQGSLMS 584

  Fly   717 ----------VI--------RILRDLCQRVSSWQSLP-QWSLELLVEKVISSA 750
                      :|        .:.|.:.||::..:.|| |:||...:...||:|
Zfish   585 YFSEPIYFSSIILGSLYHADHLSRAMYQRIADIEDLPQQFSLNRPLLSGISNA 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	1/8 (13%)
		C2H2 Zn finger	207..229	CDD:275371	0/1 (0%)
		ZnF_U1	252..284	CDD:197732	7/38 (18%)
		C2H2 Zn finger	255..277	CDD:275371	5/28 (18%)
		ZnF_U1	368..396	CDD:197732	5/27 (19%)
		C2H2 Zn finger	368..390	CDD:275371	2/21 (10%)
		DZF	577..829	CDD:128842	48/263 (18%)
adarb1b	XP_021334693.1	DSRM	127..189	CDD:214634	14/61 (23%)
		DSRM	284..>329	CDD:238007	6/46 (13%)
		ADEAMc	371..747	CDD:214718	51/292 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840