DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and adarb2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_686426.5	Gene:	adarb2 / 558149	ZFINID:	ZDB-GENE-060503-160	Length:	740	Species:	Danio rerio

Alignment Length:	468	Identity:	89/468 - (19%)
Similarity:	133/468 - (28%)	Gaps:	165/468 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GTQY----NTGQVSYPAVTNATYANAAAYQNAAVAAGQGGYGGAAGAGAGATSGPGAGGYGGYGD 73
            |.||    .||.|..|..:.|...|...::                 |.|.|...        ..
Zfish   138 GLQYRMVSQTGPVHAPLFSIAVEVNGLTFE-----------------GTGPTKKK--------AK 177

  Fly    74 YRSAMQYDATKTFYQQSPASY------NASGSTASVSKTHYSAPPVKNQVKGKMDKSNGGPKPPS 132
            .::|..  |.|:|.|...||.      ..|..||..:......|  ....||         ..|.
Zfish   178 MKAAEM--ALKSFIQFPNASQAHLAMGGLSNPTADFTSDQADFP--DTLFKG---------FEPD 229

  Fly   133 SAPPAGNNYSGYDTALYNAASMYVAQQHQGNPNQKPNGGANNWYQRKMGATIPGATAIRGMRPKA 197
            ....|.|........|.:...:.|.|..|.:|                  .:|.|       |.:
Zfish   230 GCRSAENELLSSALRLRHTLDLMVVQARQEDP------------------CLPPA-------PVS 269

  Fly   198 PPRPQQ----------LHYCEVCKISCA-GPQTYREHL----------EGQKHKKREASLKMSAS 241
            ||:|..          |.|  .|....| |.:.:|..:          ||....|::|..:.:..
Zfish   270 PPQPSPVVLLNDLRPGLRY--ACLSEHAQGKRAHRSFIMAVRVDGRIFEGSGRSKKQAKRQAAVC 332

  Fly   242 ANSATQNRGNNYHCELCDVTCTGTDAYAAHVRGAKHQKVVKLHQKLGKPIPSEEPKKMGKI---- 302
            |..|..|            .....:|.|.|  .....|...|.|:....|.....:|..::
Zfish   333 ALQALFN------------FRLAPEARAGH--RPSRIKCPHLPQEFADGIFQLVREKYSELAGCS 383

  Fly   303 NFVPAAAGG-AGVAKTEGGANESDAAGDLDDNLDDSLGENTDNIKPVGGEYIEEVKDEEGKILSF 366
            :.:.|...| ||:..|.|        .||......:|...|   |.:.||||    .::|.:::
Zfish   384 SLLHARHKGLAGIVMTRG--------LDLRHAQVVALSSGT---KCINGEYI----SDQGLVVN- 432

  Fly   367 NCKLCDCKFNDPNAK----------EMHMKGR----------RHR---LQYKRKVQPDLVVDFKP 408
                 ||.......:          |:|:..|          ||:   |:.:..|...:.:...|
Zfish   433 -----DCHAEITTRRALLRFLYSQLELHLSKRKEDWEQSIFVRHKDSCLRLRENVLFHMYISTSP 492

  Fly   409 TPRQRRLAEARAN 421
                  ..:||.|
Zfish   493 ------CGDARVN 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	9/41 (22%)
		C2H2 Zn finger	207..229	CDD:275371	6/32 (19%)
		ZnF_U1	252..284	CDD:197732	4/31 (13%)
		C2H2 Zn finger	255..277	CDD:275371	3/21 (14%)
		ZnF_U1	368..396	CDD:197732	8/50 (16%)
		C2H2 Zn finger	368..390	CDD:275371	5/41 (12%)
		DZF	577..829	CDD:128842
adarb2	XP_686426.5	DSRM	125..>172	CDD:214634	11/50 (22%)
		dsrm	278..337	CDD:278464	11/60 (18%)
		ADEAMc	364..737	CDD:214718	31/163 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840