DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and strbp

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_005155660.1	Gene:	strbp / 557957	ZFINID:	ZDB-GENE-030729-18	Length:	696	Species:	Danio rerio

Alignment Length:	458	Identity:	172/458 - (37%)
Similarity:	249/458 - (54%)	Gaps:	79/458 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 RPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSD----ALAEQPSDAGAANKKDKA 548
            |....||||.:|:|:.|||..|:|:.:|.:||..|.|||.|||    :.|.|.:...|::.:::.
Zfish     5 RSFGNDDRHVMAKHSTIYPSSEDLEAVQSLVSTVECALKHVSDWMDQSQASQSNPTNASSTQEEE 69

  Fly   549 EKPS---EKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPT 610
            .:|:   ..:|..|:..|.......||    :|.||||:|.:|||||:..|..:|||::|.|.||
Zfish    70 TEPTVDESPEGSTNEESSCSSGPSEGG----VLCGVMRIGLVAKGLLIKDDMDLELVLMCRENPT 130

  Fly   611 SGLLQRVANVLPDKLKEVAGDTQVNYRVEVNAEEAALIV---LDESVSVKITLTSPLLRDANPGE 672
            ..||..|...||.:::::   |:..|.|:....|||::|   .:..:::|:|||||..:|....|
Zfish   131 KTLLSTVCEHLPQQIEKL---TEEKYEVQQCIPEAAILVCTTTEPKLTLKVTLTSPQFKDDCETE 192

  Fly   673 AATTDEGEGDSEFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQW 737
            ...:.|....::.|.|:.||.|||.||||||||||..||:|||:|:||||.:|.||.:|:.|..|
Zfish   193 EQESVESSEPADLLDRQRCLVALASLRHAKWFQARVNGLKSCVIVLRILRHMCNRVPAWEPLKGW 257

  Fly   738 SLELLVEKVISSAGFPISPGDCMRRIMEALSSGFLI-NGPGLLDPCEKDPTDALLELTKQEREDL 801
            .|||:.||.|::...|:..|:.:||:||.|:||.|: .||||.|||||:||:.|..:|.:|.|.:
Zfish   258 PLELICEKAIATCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCEKEPTNTLSAMTDEEAEAI 322

  Fly   802 TVSAQLFLRYIAFRQIYKVLGMEPL----PAMKFP---------MRPWR--------VNRKRRRS 845
            |.:||..||.:||.||||||.|:||    |:.|:|         .||:.        :.:|.:|:
Zfish   323 TSNAQHALRLMAFGQIYKVLDMDPLPSSKPSQKYPWSDKEGLGLKRPYEDGLMDDKDLIKKMKRN 387

  Fly   846 SGKA--------------------GGAPGTE---------------TESNDIDET-----GSDEK 870
            ..||                    ...||.:               |.|.|:|.|     ||.:|
Zfish   388 LRKAVLDSKAIDSNQPMNALMRLNQIRPGLQYKLLSQSGPVHAPVFTMSVDVDGTVYEASGSSKK 452

  Fly   871 VAK 873
            .||
Zfish   453 TAK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732
		C2H2 Zn finger	207..229	CDD:275371
		ZnF_U1	252..284	CDD:197732
		C2H2 Zn finger	255..277	CDD:275371
		ZnF_U1	368..396	CDD:197732
		C2H2 Zn finger	368..390	CDD:275371
		DZF	577..829	CDD:128842	121/259 (47%)
strbp	XP_005155660.1	DZF	97..350	CDD:128842	120/255 (47%)
		DSRM	403..467	CDD:214634	12/53 (23%)
		DSRM	525..>571	CDD:214634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594006
Domainoid	1	1.000	270	1.000	Domainoid score	I1783
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45762
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.040