DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and STRBP

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_016870379.1	Gene:	STRBP / 55342	HGNCID:	16462	Length:	674	Species:	Homo sapiens

Alignment Length:	397	Identity:	179/397 - (45%)
Similarity:	239/397 - (60%)	Gaps:	39/397 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 RPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPS 552
            |..:.||||.:.:|:.|||..|||:.:|.:||..|.|||.|||.|.|       .||..|.|..:
Human     5 RSFANDDRHVMVKHSTIYPSPEELEAVQNMVSTVECALKHVSDWLDE-------TNKGTKTEGET 62

  Fly   553 EKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPTSGLLQRV 617
            |.. :|....::.|  |.||   |.|.||||:|.:|||||:..|..:|||::|.:|||..||..|
Human    63 EVK-KDEAGENYSK--DQGG---RTLCGVMRIGLVAKGLLIKDDMDLELVLMCKDKPTETLLNTV 121

  Fly   618 ANVLPDKLKEVAGDTQVNYRVEVNAEEAALIV---LDESVSVKITLTSPLLRDANPGEAATTDEG 679
            .:.||.:::::   |:..|:||....||::|:   .:.::::|:.|||||:||    |....| |
Human   122 KDNLPIQIQKL---TEEKYQVEQCVNEASIIIRNTKEPTLTLKVILTSPLIRD----ELEKKD-G 178

  Fly   680 EGDS-----EFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQWSL 739
            |..|     :.|.|:.||.|||.|||||||||||.||:|||:|:|||||||.||.:|..|..|.|
Human   179 ENVSMKDPPDLLDRQKCLNALASLRHAKWFQARANGLKSCVIVLRILRDLCNRVPTWAPLKGWPL 243

  Fly   740 ELLVEKVISSAGFPISPGDCMRRIMEALSSGFLI-NGPGLLDPCEKDPTDALLELTKQEREDLTV 803
            ||:.||.|.:...|:..|:.:||:||.|:||.|: .||||.||||:||||||..:|.|::||:|.
Human   244 ELICEKSIGTCNRPLGAGEALRRVMECLASGILLPGGPGLHDPCERDPTDALSYMTIQQKEDITH 308

  Fly   804 SAQLFLRYIAFRQIYKVLGMEPLPAMK-FPMRPWRVNRKRRRSSGKAGGAPGTETESNDIDETGS 867
            |||..||..||.||||||.|:|||:.| |....|.|..|.        ||..:..:....|..|.
Human   309 SAQHALRLSAFGQIYKVLEMDPLPSSKPFQKYSWSVTDKE--------GAGSSALKRPFEDGLGD 365

  Fly   868 DEKVAKK 874
            |:...||
Human   366 DKDPNKK 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732
		C2H2 Zn finger	207..229	CDD:275371
		ZnF_U1	252..284	CDD:197732
		C2H2 Zn finger	255..277	CDD:275371
		ZnF_U1	368..396	CDD:197732
		C2H2 Zn finger	368..390	CDD:275371
		DZF	577..829	CDD:128842	132/260 (51%)
STRBP	XP_016870379.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158129
Domainoid	1	1.000	267	1.000	Domainoid score	I1878
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950