DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and ilf3a

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001025236.1	Gene:	ilf3a / 324431	ZFINID:	ZDB-GENE-030131-3151	Length:	820	Species:	Danio rerio

Alignment Length:	500	Identity:	176/500 - (35%)
Similarity:	256/500 - (51%)	Gaps:	110/500 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 YW-----EEQRNRQYNEE-YDYNNWMSRSFGGAQRFGRMGNGPPPHFGMMPGGNVRRPESTDDRH 496
            ||     .|:..||||:. .:|..|...:....:....|  .|||          :|....:||:
Zfish    58 YWYDCLCYEEDLRQYNDYIVEYRKWEEENLHPEEPMPPM--RPPP----------QRTFVNEDRY 110

  Fly   497 AIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKDGRDNQI 561
            ..|:|..:||..|:|..:|.:|||.|.|:|.|||...|:  :||..:.|.|:.:..
Zfish   111 LRAKHTTVYPSSEQLDAVQNMVSHIEFAMKAVSDWFNEK--EAGDTDTKSKSSQSK--------- 164

  Fly   562 FSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPTSGLLQRVANVLPDKLK 626
                            |:||:|||.:||||||..|..:|||:|..:.|||.||:.|:..|.:.:|
Zfish   165 ----------------LRGVLRVGLVAKGLLLKDDLDLELVLLTRDAPTSSLLRLVSGKLSELIK 213

  Fly   627 EVAGDTQVNYRVEVNAEEAALIVL---DESVSVKITLTSPLLRDANPGEAATTDEGEGDSEFLP- 687
            :|   |:..|.:..:.:||::||.   :..:.::|.||||::|:....||:    ||..:|..|
Zfish   214 DV---TEEKYVITPSIQEASVIVTSTKEPLLKLRIHLTSPVVREQVEKEAS----GEPCAESSPQ 271

  Fly   688 ----REPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQWSLELLVEKVIS 748
                |:.||.:||.||.||.|||:.:||:|||:|||||||||.|||:|..|..|:||||.:|.||
Zfish   272 DALDRQKCLASLASLRQAKRFQAKVSGLESCVIVIRILRDLCSRVSTWAPLKGWTLELLCQKAIS 336

  Fly   749 SAGFPISPGDCMRRIMEALSSGFLI-NGPGLLDPCEKDPTDALLELTKQEREDLTVSAQLFLRYI 812
            ::...:.||:..||::|.|:||.:: .|||:.||||:|.|||.:.||.|:|||:|.|||..||..
Zfish   337 TSERMLGPGEAFRRVLECLASGIIMEGGPGISDPCERDTTDAAVYLTSQQREDITQSAQFALRLS 401

  Fly   813 AFRQIYKVLGMEPLPA------------------------------MKFPMRPWR---------V 838
            ||.|:||||||:.|.:                              :|||.:..|         :
Zfish   402 AFGQLYKVLGMDRLTSKAARMIEHRVPDPPIKRPRESFDGGDFDTRLKFPRKEERKEPPNALMKL 466

  Fly   839 NRKRRRSSGKAGGAPGTETESN-----DID-----ETGSDEKVAK 873
            |:.|..:..|.....|.|.|..     ::|     .||..::.||
Zfish   467 NQLRPGTVYKLASQTGPEHEPQFSMTVEVDGVTYEATGPSKRSAK 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732
		C2H2 Zn finger	207..229	CDD:275371
		ZnF_U1	252..284	CDD:197732
		C2H2 Zn finger	255..277	CDD:275371
		ZnF_U1	368..396	CDD:197732
		C2H2 Zn finger	368..390	CDD:275371
		DZF	577..829	CDD:128842	124/290 (43%)
ilf3a	NP_001025236.1	DZF	165..418	CDD:295427	124/259 (48%)
		DSRM	459..523	CDD:214634	10/52 (19%)
		DSRM	572..>622	CDD:214634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850