DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zn72D and zfr

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_955852.2	Gene:	zfr / 321659	ZFINID:	ZDB-GENE-030131-378	Length:	1074	Species:	Danio rerio

Alignment Length:	1100	Identity:	437/1100 - (39%)
Similarity:	571/1100 - (51%)	Gaps:	301/1100 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNNYAGFNYG-GTQYNTGQVSYPAVTNATYANAAAYQNAAVAAG--QGGYGGAAGAGAGATSG 62
            ||..||.||.:| |.||:....:..|.|:.|...:.....|.|||.  ...|...|...|.|...
Zfish    23 MATGNYFGFTHGAGAQYSQQPAAGVAYTHPTTVASYTVHQAPVAAHTVAAAYAPTAATVAVARPA 87

  Fly    63 P-------GAGGYGGY------GDY----------------------------RS---AMQYDAT 83
            |       .|..:|||      .||                            ||   |:.|| :
Zfish    88 PVAVAAAANAAAFGGYQPAHAATDYGYAQRQPEVPPPPPPVTSQNYQDSYSYVRSTAPAVAYD-S 151

  Fly    84 KTFYQQSPASYNASGSTA-----SVSKTHY-SAP------------------------------- 111
            |.:||| ||:..|..:.|     :|::::| :||
Zfish   152 KQYYQQ-PAATPAVAAAAAQPQPTVAESYYQTAPKTGYSQGATPYTQTQQTRQVTVVKPATPSPA 215

  Fly   112 -------PVKNQVKGKMDKSNGGPKPPSSAPP---------AGNNYSGYDTALYNAASMYVAQQH 160
                   ||.:.|:.....:.....|..|..|         :|.:||||:.|:|:|||.|..||.
Zfish   216 TSTFSIYPVSSAVQPVAAAAAASVVPSYSQSPTYSTNAVTYSGTSYSGYEAAVYSAASSYYQQQQ 280

  Fly   161 QGNPNQKPNGGANNWYQRKMGATIPGATAI--------------RGMRPKAPPRPQQLHYCEVCK 211
            |               |:|..|....|||.              :.::||.||:|.|:|||:|||
Zfish   281 Q---------------QQKQAAVAAAATAAWTGSTFTKKTPFQNKTLKPKQPPKPPQIHYCDVCK 330

  Fly   212 ISCAGPQTYREHLEGQKHKKREASLKMSASANSA----TQNRG--NNYHCELCDVTCTGTDAYAA 270
            |||||||||:||||||||||:||:||:|.|::|:    :..||  |...||||||:|||.|||||
Zfish   331 ISCAGPQTYKEHLEGQKHKKKEAALKVSQSSSSSSGGGSSARGTQNQLRCELCDVSCTGADAYAA 395

  Fly   271 HVRGAKHQKVVKLHQKLGKPIPSEEP--------------------------------------- 296
            |:||||||||||||.||||||||.||
Zfish   396 HIRGAKHQKVVKLHTKLGKPIPSTEPSVVSQSSTSSTAAPNKTSSSNINSSTSTSSNASSSVSAS 460

  Fly   297 -----------------------------KKMG--KINFV-------------PAAAGGAGVAKT 317
                                         ||:.  |||||             .:.|..|..|::
Zfish   461 YLKSGSMAASAAQGKSSGANSVSVNSSSIKKVNTPKINFVGGNKLQTTASKSDESKADAAKTAQS 525

  Fly   318 EGGANESDAAGDLDDNL--DDSLGENTDNIKPVGGEYIEEVKDEEGKILSFNCKLCDCKFNDPNA 380
            ...|..:||..|:.|.:  ..:|.....:::|||.:|:|||:::|||::.|:||||:|.||||||
Zfish   526 AASAPAADAKNDMPDPMSPQSALAALQSDVQPVGHDYVEEVRNDEGKVIRFHCKLCECSFNDPNA 590

  Fly   381 KEMHMKGRRHRLQYKRKVQPDLVVDFKPTPRQRRLAEARANRAMMSSHRGGDDHDGGYW----EE 441
            ||||:||||||||||:||.|||.|:.||:.|.|::.|.:..:.|....         ||    ||
Zfish   591 KEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKEE---------YWRRREEE 646

  Fly   442 QR----NRQYNE-------EYDYNNWMSR---SFGGAQRFGRMGNGPPPHFGMMPG-------GN 485
            :|    .|:|.|       |.:.::|..|   ..||   :.:...|||...|:.||       |.
Zfish   647 ERWRMEMRRYEEDMYWRRMEEEQHHWEDRRRMPDGG---YPQGPPGPPGLLGVRPGMPIPQPQGP 708

  Fly   486 V--RRPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANK---K 545
            |  |||:|:|||:.:.:||.|||.|:|||.||:|||.||||||||||.:.:|  ||||:.|   :
Zfish   709 VPPRRPDSSDDRYVMTKHAAIYPSEDELQAIQKIVSITERALKLVSDIITDQ--DAGASAKGKEE 771

  Fly   546 DKAEKPSEKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPT 610
            ||.:|...||                    |:||||||||.|||||||.||..|.||:||:||||
Zfish   772 DKEKKEPPKD--------------------RLLKGVMRVGVLAKGLLLRGDKEVNLVLLCSEKPT 816

  Fly   611 SGLLQRVANVLPDKLKEVAGDTQVNYRVEVNAEEAALIVL---DESVSVKITLTSPLLRDANPGE 672
            ..||.|:...||.:|..|   |...|.|:.:.:|:|:|:.   |..:.|.||||||::|:.:..:
Zfish   817 KNLLTRIVEHLPKQLTMV---TPEKYEVKGSIQESAIILTSCGDPKMQVTITLTSPIIREESSRD 878

  Fly   673 AATTDEGEGD-SEFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQ 736
            ...|.....| ::.|.|:.||.|||.|||||||||||.||||||:||||||||||||.:|.:.|.
Zfish   879 GDVTSSMVKDPADVLDRQKCLDALAALRHAKWFQARANGLQSCVIVIRILRDLCQRVPTWSAFPS 943

  Fly   737 WSLELLVEKVISSAGFPISPGDCMRRIMEALSSGFLING-PGLLDPCEKDPTDALLELTKQERED 800
            |::||||||.||||..|:||||.:||:.|.:|||.|::| |||:|||||:|||.|..:.:|:|||
Zfish   944 WAMELLVEKAISSASGPMSPGDALRRVFECISSGILLSGAPGLIDPCEKNPTDTLAFMEEQQRED 1008

  Fly   801 LTVSAQLFLRYIAFRQIYKVLGMEPLPAM--KFPMRPWRVNRKRRRSSGKAGGAPGTETE 858
            :|.|||..||.:|||||:|||||:|||.|  :|.:|.   .|||||.:  :.||.|.|.|
Zfish  1009 ITSSAQFALRLLAFRQIHKVLGMDPLPQMNSRFNVRN---TRKRRRDN--SDGADGFEAE 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	27/30 (90%)
		C2H2 Zn finger	207..229	CDD:275371	19/21 (90%)
		ZnF_U1	252..284	CDD:197732	25/31 (81%)
		C2H2 Zn finger	255..277	CDD:275371	18/21 (86%)
		ZnF_U1	368..396	CDD:197732	24/27 (89%)
		C2H2 Zn finger	368..390	CDD:275371	18/21 (86%)
		DZF	577..829	CDD:128842	147/256 (57%)
zfr	NP_955852.2	ZnF_U1	324..353	CDD:197732	25/28 (89%)
		C2H2 Zn finger	326..348	CDD:275371	19/21 (90%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..374		15/29 (52%)
		ZnF_U1	380..409	CDD:197732	25/28 (89%)
		C2H2 Zn finger	380..402	CDD:275371	18/21 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..456		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..545		8/36 (22%)
		ZnF_U1	575..606	CDD:197732	25/30 (83%)
		C2H2 Zn finger	578..600	CDD:275371	18/21 (86%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..718		8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	761..781		8/19 (42%)
		DZF	784..1037	CDD:128842	147/255 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1036..1074		12/32 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594022
Domainoid	1	1.000	270	1.000	Domainoid score	I1783
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8009
Inparanoid	1	1.050	507	1.000	Inparanoid score	I1295
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	1	1.000	-	-		FOG0003979
OrthoInspector	1	1.000	-	-		otm26468
orthoMCL	1	0.900	-	-		OOG6_105636
Panther	1	1.100	-	-	LDO	PTHR45762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3088
SonicParanoid	1	1.000	-	-		X2736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790