DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zn72D and Zfr2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_038936366.1	Gene:	Zfr2 / 314639	RGDID:	1304737	Length:	842	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	358/979 - (36%)
Similarity:	484/979 - (49%)	Gaps:	235/979 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNNYAGFNYGGTQYNTGQVSYPAVTNATYANAAAYQNAAVAAGQGGYGGAAGAGAGATSGPGA 65
            ||.::.:|...|.:..:..|   |:.|.:..|..|:|...:....:    .........||.|.|
  Rat     1 MAASSSSGLAQGASPSSDTQ---PSSTLSLPATGASYTVPSTPRMK----STVSLALAPTSQPPA 58

  Fly    66 --GGYGGYGDYRSAMQYDATKTFYQQSPASYNAS-GSTASVSKTHY--------SAPPVKNQVKG 119
              ||.        .:.|..::....|.|.|.:.| |...:.:.||.        .|...:...:.
  Rat    59 PRGGV--------TVGYSCSQPHPSQGPTSNSRSRGPVPTTASTHQEDGHSCREKATKSRTDSRE 115

  Fly   120 KMDKSNGGPKPPSSAPPAGNNYSGYDTALYNAASMYVAQQHQGNPNQKPNGGANNWYQRKMGATI 184
            :..:|...|.|.|.:|.:.:                |:....|.|...|      |........:
  Rat   116 RPARSLSRPGPSSRSPDSDS----------------VSPDSWGGPVLGP------WDPTFTSDAL 158

  Fly   185 PGATAIRGMRPKAPPRPQQLHYCEVCKISCAGPQTYREHLEGQKHKKREASLKMSASANSATQNR 249
            |...  |..:|||.|||..:||||||::|||||||||:|||||||:|::|:.:      :.||..
  Rat   159 PFLD--RLPKPKAGPRPPSMHYCEVCRVSCAGPQTYRDHLEGQKHRKKQAAQR------TRTQPS 215

  Fly   250 G-----NNYHCELCDVTCTGTDAYAAHVRGAKHQKVVKLHQKLGKPIPSE-EPKKM--------- 299
            |     .:.||.||.|:|||.||||||:|||:||||.|||.:|||||||| .|:.:
  Rat   216 GGPRGSQSLHCGLCAVSCTGADAYAAHMRGARHQKVFKLHTRLGKPIPSEPTPRSVTYTRGSDST 280

  Fly   300 ------------------GKINFVPAAAGGAGVAK-------------------------TEGGA 321
                              |:    ||.|.|...::                         |.||:
  Rat   281 PETSVKHEAHARHSSHTQGR----PAPAKGPAASRKGSPELQTVHSWPGDRRPSHCKAEATRGGS 341

  Fly   322 NE-SDAAGDLDDNLDDSLGENTDNIKPVGGEYIEEVKDEEGKILSFNCKLCDCKFNDPNAKEMHM 385
            .| |..:||.:               |||.||:|:|..||||::.|.||||:|.|||.||::||:
  Rat   342 GEASGISGDTE---------------PVGTEYVEQVCSEEGKVIRFRCKLCECSFNDRNARDMHL 391

  Fly   386 KGRRHRLQYKRKVQPDLVVDFKPT-PRQRRLAEARANRAMMSSHRGGDDHDGGYWEEQRNRQYNE 449
            .||||||||::||.|.|.|..:|: |.||.||:....:...:..|   ..|...|..:..:|  |
  Rat   392 TGRRHRLQYRKKVDPTLPVATRPSGPMQRVLAKRLQRQRQQTQAR---LEDAQRWNSELRQQ--E 451

  Fly   450 EYDYNNWMSRSFGGAQRFGRMGNGPP-PHF-GMMPGG--------------------NVRRPEST 492
            |:                .|....|| |.. ..:||.                    :.|||||:
  Rat   452 EH----------------SRQPEEPPQPQVEEQLPGSPTWALPAPTTRPGMASPRRQSGRRPESS 500

  Fly   493 DDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKDGR 557
            ||||.:.:||.|||.|||||.||..||||||||:||||.|||:.|..|..     ...|.
  Rat   501 DDRHVMYKHASIYPTEEELQAIQTAVSHTERALRLVSDTLAEESSQQGTL-----VSPPP----- 555

  Fly   558 DNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPTSGLLQRVANVLP 622
                              |:||||:|||.|||||:|.||::|:|.:||::|||..||||:...||
  Rat   556 ------------------RMLKGVVRVGILAKGLVLRGDHSVQLTLLCSKKPTHSLLQRIKQELP 602

  Fly   623 DKLKEVAGDTQVNYRVEVNAEEAALIVL----DESVSVKITLTSPLLRDANPGEAATTDEGEGDS 683
            .:|..||.|     :.||:::..|.||:    :..|.|.::.||||:|:....:....|......
  Rat   603 RELSIVAED-----KYEVSSDHDANIVISACVEPGVKVTVSATSPLMREDPSVKQELQDSLSDPE 662

  Fly   684 EFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQWSLELLVEKVIS 748
            :.|.||.||..||.|||||||||||:|||.||:|||:|||||:.:..|.:||.|::|||||||:|
  Rat   663 DILDRERCLETLAALRHAKWFQARASGLQPCVIVIRVLRDLCRCLPPWGALPAWAMELLVEKVLS 727

  Fly   749 SAGFPISPGDCMRRIMEALSSGFLI-NGPGLLDPCEKDPTDALLELTKQEREDLTVSAQLFLRYI 812
            ||..|:||||.|||::|.:::|.|: :||||.|||||.|.|||..:|.|:|||||.|||..||.:
  Rat   728 SAPRPLSPGDAMRRVLEYVATGALLTDGPGLQDPCEKGPQDALEPMTPQQREDLTASAQHALRLV 792

  Fly   813 AFRQIYKVLGMEPLPAMKFPMRPWRVNRKRRRSSGKAGGAPGTETESNDIDETGSDEKVAKKEGV 877
            |||||:|||.||.||    |...:.. |||.|.:.:.              :.|:.|:...::|.
  Rat   793 AFRQIHKVLHMEHLP----PRTRFGA-RKRMREASQT--------------QEGARERKRGRQGT 838

  Fly   878 GGTP 881
            .|.|
  Rat   839 AGLP 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	24/30 (80%)
		C2H2 Zn finger	207..229	CDD:275371	18/21 (86%)
		ZnF_U1	252..284	CDD:197732	22/31 (71%)
		C2H2 Zn finger	255..277	CDD:275371	16/21 (76%)
		ZnF_U1	368..396	CDD:197732	20/27 (74%)
		C2H2 Zn finger	368..390	CDD:275371	14/21 (67%)
		DZF	577..829	CDD:128842	138/256 (54%)
Zfr2	XP_038936366.1	PHA03247	<20..310	CDD:223021	104/338 (31%)
		ZnF_U1	177..204	CDD:197732	22/26 (85%)
		C2H2 Zn finger	179..225	CDD:275371	25/51 (49%)
		ZnF_U1	224..255	CDD:197732	22/30 (73%)
		C2H2 Zn finger	226..248	CDD:275371	16/21 (76%)
		zf-met	372..396	CDD:403930	15/23 (65%)
		C2H2 Zn finger	374..396	CDD:275371	14/21 (67%)
		DZF	558..809	CDD:295427	138/259 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352120
Domainoid	1	1.000	268	1.000	Domainoid score	I1784
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1244
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	1	1.000	-	-		FOG0003979
OrthoInspector	1	1.000	-	-		otm44840
orthoMCL	1	0.900	-	-		OOG6_105636
Panther	1	1.100	-	-	O	PTHR45762
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2736
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760