DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and Stau2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_079579.2	Gene:	Stau2 / 29819	MGIID:	1352508	Length:	570	Species:	Mus musculus

Alignment Length:	618	Identity:	111/618 - (17%)
Similarity:	182/618 - (29%)	Gaps:	229/618 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SAPPAGNNYS-----GYDTALYNAASMYVAQQHQGN----------PNQK-PNGGANNWYQRKMG 181
            |.|.....:|     |..|.....:|:..|||...|          |.|| |....||    ..|
Mouse    32 SGPAHSKMFSVQLSLGEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNN----NPG 92

  Fly   182 ATIPGATAIRGMRPKAPPRPQQLHYCEVCKISCAGPQTYREHLEGQKHKKREASLKMSASANSAT 246
            :..| ...:.|:..|.                 ..|..||. |:.:......|:.......|
Mouse    93 SITP-TVELNGLAMKR-----------------GEPAIYRP-LDPKPFPNYRANYNFRGMYN--- 135

  Fly   247 QNRGNNYHCELCDV----TCTGTDAYAAHVR---GAKHQKVVKLHQKL-GKPIPSEEPKKMGKIN 303
                ..|||.:..:    ...|.:.:....:   .|:|...:|..|.| .:|||.:.|:.
Mouse   136 ----QRYHCPMPKIFYVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPEKSPQN----- 191

  Fly   304 FVPAAAGGAGVAKTEGGANESDAAGDLDDNLDDSLGENTDNIK-----------PVGGEYIEEVK 357
                                    |:....:||....|...|.           ||..|.|:|..
Mouse   192 ------------------------GESGKEMDDDKDANKSEISLVFEIALKRNMPVSFEVIKESG 232

  Fly   358 DEEGKILSFNCKLCDCKFN---DPNAKEMHMKG------------------RRHRLQYKR----- 396
            ....|  ||..::...:|:   :.|:|::..|.                  .:.:|.:|:
Mouse   233 PPHMK--SFVTRVSVGEFSAEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTI 295

  Fly   397 -KVQPDLVVDFKPTPRQRRLAEARANRA---MMSSHRGGDDHDGGYWEEQRNRQYNEEYDYNNWM 457
             |..||......|..|..::.:||..:.   ::.|.||          ..|.|::..:....|.:
Mouse   296 VKAGPDYGQGMNPISRLAQIQQARKEKEPDYILLSERG----------MPRRREFVMQVKVGNEV 350

  Fly   458 SRSFGGAQRFGRMG------------------------------NGPPPHFGMMPGGNVRRPEST 492
            :...|..::..:..                              :||.|.|          ||.|
Mouse   351 ATGTGPNKKIAKKNAAEAMLLQLGYKASTSLQDPLDKTGENKGWSGPKPGF----------PEPT 405

  Fly   493 DDRHAIARH--AEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKD 555
            ::......|  .::|.:.|..:  .|:.|.|  .|..:|.....|||
Mouse   406 NNTPKGILHLSPDVYQEMEASR--HRVTSGT--TLSYLSPKDMNQPS------------------ 448

  Fly   556 GRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDN-AVELVVLCAEKPTSGLLQRVAN 619
               :..||....:.:...|             |:.||::|.: ..|.:.|....|||    ..::
Mouse   449 ---SSFFSVSPSSTSSATV-------------ARELLMNGTSPTAEAIGLKGSSPTS----PCSS 493

  Fly   620 VLPDKLKEVAGDTQVNYRVEVNAEEAALIVLDE 652
            |.|.|        |:.|...:...:|||..|.:
Mouse   494 VQPSK--------QLEYLARIQGFQAALSALKQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	5/30 (17%)
		C2H2 Zn finger	207..229	CDD:275371	4/21 (19%)
		ZnF_U1	252..284	CDD:197732	7/38 (18%)
		C2H2 Zn finger	255..277	CDD:275371	3/28 (11%)
		ZnF_U1	368..396	CDD:197732	5/48 (10%)
		C2H2 Zn finger	368..390	CDD:275371	4/42 (10%)
		DZF	577..829	CDD:128842	18/77 (23%)
Stau2	NP_079579.2	DSRM_STAU2_rpt1	3..70	CDD:380709	10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..94		7/26 (27%)
		DSRM_STAU2_rpt2	98..179	CDD:380711	16/105 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..203		8/53 (15%)
		DSRM_STAU2_rpt3	206..272	CDD:380713	13/67 (19%)
		Nuclear localization signal 1	273..291		2/17 (12%)
		DSRM_STAU2_rpt4	304..389	CDD:380715	11/94 (12%)
		Nuclear localization signal 2. /evidence=ECO:0000250	373..412		7/48 (15%)
		Required for dendritic transport. /evidence=ECO:0000250	381..570		39/198 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..413		7/41 (17%)
		Staufen_C	465..523	CDD:374568	18/66 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848526
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930