DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and STAU2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001157852.1	Gene:	STAU2 / 27067	HGNCID:	11371	Length:	570	Species:	Homo sapiens

Alignment Length:	599	Identity:	110/599 - (18%)
Similarity:	182/599 - (30%)	Gaps:	216/599 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 GYDTALYNAASMYVAQQHQGN----------PNQK-PNGGANNWYQRKMGATIPGATAIRGMRPK 196
            |..|.....:|:..|||...|          |.|| |....||    ..|:..| ...:.|:..|
Human    47 GEQTWESEGSSIKKAQQAVANKALTESTLPKPVQKPPKSNVNN----NPGSITP-TVELNGLAMK 106

  Fly   197 APPRPQQLHYCEVCKISCAGPQTYREHLEGQKHKKREASLKMSASANSATQNRGNNYHCELCDV- 260
            .                 ..|..||. |:.:......|:.......|       ..|||.:..:
Human   107 R-----------------GEPAIYRP-LDPKPFPNYRANYNFRGMYN-------QRYHCPVPKIF 146

  Fly   261 ---TCTGTDAYAAHVR---GAKHQKVVKLHQKL-GKPIPSEEPKKMGKINFVPAAAGGAGVAKTE 318
               ...|.:.:....:   .|:|...:|..|.| .:|||...|                     :
Human   147 YVQLTVGNNEFFGEGKTRQAARHNAAMKALQALQNEPIPERSP---------------------Q 190

  Fly   319 GGANESDAAGDLDDNLDD-------SLGENTDNIKPVGGEYIEEVKDEEGKILSFNCKLCDCKFN 376
            .|.:..|...|.|.|..:       :|..|    .||..|.|:|......|  ||..::...:|:
Human   191 NGESGKDVDDDKDANKSEISLVFEIALKRN----MPVSFEVIKESGPPHMK--SFVTRVSVGEFS 249

  Fly   377 ---DPNAKEMHMK-GRRHRLQYKRKVQPDLVVD-----FKPTPRQ---------------RRLAE 417
               :.|:|::..| .....||..:|:.|..||:     ||..|:.               .|||:
Human   250 AEGEGNSKKLSKKRAATTVLQELKKLPPLPVVEKPKLFFKKRPKTIVKAGPEYGQGMNPISRLAQ 314

  Fly   418 ARANRA------MMSSHRGGDDHDGGYWEEQRNRQYNEEYDYNNWMSRSFGGAQRFGRMG----- 471
            .:..:.      ::.|.||          ..|.|::..:....|.::...|..::..:..
Human   315 IQQAKKEKEPDYVLLSERG----------MPRRREFVMQVKVGNEVATGTGPNKKIAKKNAAEAM 369

  Fly   472 -------------------------NGPPPHFGMMPGGNVRRPESTDDRHAIARH--AEIYPKEE 509
                                     :||.|.|          ||.|::......|  .::|.:.|
Human   370 LLQLGYKASTNLQDQLEKTGENKGWSGPKPGF----------PEPTNNTPKGILHLSPDVYQEME 424

  Fly   510 ELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSEKDGRDNQIFSFQKDADNGGNV 574
            ..:  .:::|.|  .|..:|.....|||                     :..||....:::...:
Human   425 ASR--HKVISGT--TLGYLSPKDMNQPS---------------------SSFFSISPTSNSSATI 464

  Fly   575 VRILKGVMRVGYLAKGLLLHG-DNAVELVVLCAEKPTSGLLQRVANVLPDKLKEVAGDTQVNYRV 638
                         |:.||::| .:..|.:.|....||    ...:.|.|.|        |:.|..
Human   465 -------------ARELLMNGTSSTAEAIGLKGSSPT----PPCSPVQPSK--------QLEYLA 504

  Fly   639 EVNAEEAALIVLDE 652
            .:...:|||..|.:
Human   505 RIQGFQAALSALKQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	5/30 (17%)
		C2H2 Zn finger	207..229	CDD:275371	4/21 (19%)
		ZnF_U1	252..284	CDD:197732	7/38 (18%)
		C2H2 Zn finger	255..277	CDD:275371	3/28 (11%)
		ZnF_U1	368..396	CDD:197732	6/31 (19%)
		C2H2 Zn finger	368..390	CDD:275371	4/25 (16%)
		DZF	577..829	CDD:128842	17/77 (22%)
STAU2	NP_001157852.1	DSRM	9..70	CDD:214634	7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..94		7/26 (27%)
		DSRM	96..180	CDD:214634	17/109 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..203		7/42 (17%)
		DSRM	209..273	CDD:214634	16/69 (23%)
		Nuclear localization signal 1. /evidence=ECO:0000250	273..291		6/17 (35%)
		DSRM	308..374	CDD:214634	10/75 (13%)
		Nuclear localization signal 2. /evidence=ECO:0000250	373..412		7/48 (15%)
		Required for dendritic transport. /evidence=ECO:0000250	381..570		36/198 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..409		7/31 (23%)
		Staufen_C	459..523	CDD:318642	17/85 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158139
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930