DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and ZFR2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	XP_011526133.1	Gene:	ZFR2 / 23217	HGNCID:	29189	Length:	940	Species:	Homo sapiens

Alignment Length:	995	Identity:	379/995 - (38%)
Similarity:	509/995 - (51%)	Gaps:	239/995 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGGTQYNTGQ-VSY---------PAVTNATYANAAAY-QNAAV-----------AAGQGGYGGAA 53
            |||.|.::|| .:|         .|.|.|||.::.:| |:||.           ||.|.|...||
Human    57 YGGYQPHSGQDFAYGSRPQEPVPTATTMATYQDSYSYGQSAAARSYEDRPYFQSAALQSGRMTAA 121

  Fly    54 GAGAGATSGPGAGGYGGYGDYRSAMQYDATKTFYQQSPASYNASGSTASVSKTHYSAPPVKNQVK 118
            .:|...|. ...|....:|.:..|..       .||:|..  .||..||...:.|:.|...
Human   122 DSGQPGTQ-EACGQPSPHGSHSHAQP-------PQQAPIV--ESGQPASTLSSGYTYPTAT---- 172

  Fly   119 GKMDKSNGGPKPPSSA-------PPAGN---------NYSGYDTALYNAASMYVAQQH----QGN 163
                    |.:|.|||       ||:.|         :|..||.::|:|||.:.....    .|.
Human   173 --------GVQPESSASIVTSYPPPSYNPTCTAYTAPSYPNYDASVYSAASPFYPPAQPPPPPGP 229

  Fly   164 PNQKP------NGGANNWYQRK--MGATIPGATAIRGMRPKAPPRPQQLHYCEVCKISCAGPQTY 220
            |.|.|      ..|::.....|  :.:.:|        ||||.||..|||||::|||||||||||
Human   230 PQQLPPPPAPAGSGSSPRADSKPPLPSKLP--------RPKAGPRQLQLHYCDICKISCAGPQTY 286

  Fly   221 REHLEGQKHKKREASLKMSASANSATQNRGNNYHCELCDVTCTGTDAYAAHVRGAKHQKVVKLHQ 285
            ||||.||||:|:||:.|.....|.:.:......||:||.|:|||.||||||:||:|||||.|||.
Human   287 REHLGGQKHRKKEAAQKTGVQPNGSPRGVQAQLHCDLCAVSCTGADAYAAHIRGSKHQKVFKLHA 351

  Fly   286 KLGKPIPSEEP-------------------------------------KKMGKINFVPAAAG--- 310
            |||||||:.||                                     |.:.:....|.|||
Human   352 KLGKPIPTLEPALATESPPGAEAKPTSPTGPSVCASSRPALAKRPVASKALCEGPPEPQAAGCRP 416

  Fly   311 -----------GAGVAKTEGGANESDAAGDLDDNLDDSLGENTDNIKPVGGEYIEEVKDEEGKIL 364
                       |.| |.|:||:.|:.|              ...:.:|||.||:|||..:||::|
Human   417 QWGKPAQPKLEGPG-APTQGGSKEAPA--------------GCSDAQPVGPEYVEEVFSDEGRVL 466

  Fly   365 SFNCKLCDCKFNDPNAKEMHMKGRRHRLQYKRKVQPDLVVDFKPTPRQRRLAEAR-------ANR 422
            .|:||||:|.|||.|||::|::||||||||::||.|||.:..:|:.|.|::.|.|       |..
Human   467 RFHCKLCECSFNDLNAKDLHVRGRRHRLQYRKKVNPDLPIATEPSSRARKVLEERMRKQRHLAEE 531

  Fly   423 AMMSSHRGGDDHDGGYWEEQRNRQYNEEYDYN-------NWMSRSFGGAQRFGRMGNGPPPHFGM 480
            .:....|         |..:| |:..||...:       :|......|...       .|....:
Human   532 RLEQLRR---------WHAER-RRLEEEPPQDVPPHAPPDWAQPLLMGRPE-------SPASAPL 579

  Fly   481 MPGGNVRRPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKK 545
            .||   |||.|:||||.:.:||.|||.|:||..:||.|||.|||||||||.|||:
Human   580 QPG---RRPASSDDRHVMCKHATIYPTEQELLAVQRAVSHAERALKLVSDTLAEE---------- 631

  Fly   546 DKAEKPSEKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPT 610
            |:..:..|.|.|.:.           ....|:||||||||.|||||||.||..|.|.:||:||||
Human   632 DRGRREEEGDKRSSV-----------APQTRVLKGVMRVGILAKGLLLRGDRNVRLALLCSEKPT 685

  Fly   611 SGLLQRVANVLPDKLKEVAGDTQVNYRVEVNAEEAALIVL----DESVSVKITLTSPLLRDANPG 671
            ..||:|:|..||.:|:.|..|     ..||:::..|.||:    :..:.|.|::||||:|:....
Human   686 HSLLRRIAQQLPRQLQMVTED-----EYEVSSDPEANIVISSCEEPRMQVTISVTSPLMREDPST 745

  Fly   672 EAATTDEGEGDS-EFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLP 735
            :....:|.:.|: :.|..:.||.:||.||||:||||||:|||.||:|||:|||||:||.:|.:||
Human   746 DPEGVEEPQADAGDVLSPKKCLESLAALRHARWFQARASGLQPCVIVIRVLRDLCRRVPTWGALP 810

  Fly   736 QWSLELLVEKVISSAGFPISPGDCMRRIMEALSSGFLI-NGPGLLDPCEKDPTDALLELTKQERE 799
            .|::||||||.:|||..|:.|||.:||::|.:::|.|: :||||.||||:|.||||..:|.||||
Human   811 AWAMELLVEKAVSSAAGPLGPGDAVRRVLECVATGTLLTDGPGLQDPCERDQTDALEPMTLQERE 875

  Fly   800 DLTVSAQLFLRYIAFRQIYKVLGMEPLP-----AMKFPMRPWRVNRKRRRSSGKAGGAPGTETES 859
            |:|.|||..||.:||||.:|||||:.||     ..:|        |||:|..|:.
Human   876 DVTASAQHALRMLAFRQTHKVLGMDLLPPRHRLGARF--------RKRQRGPGEG---------- 922

  Fly   860 NDIDETGSDEKVAKKEGVGG 879
                |.|:.||...:.|..|
Human   923 ----EEGAGEKKRGRRGGEG 938

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	25/30 (83%)
		C2H2 Zn finger	207..229	CDD:275371	18/21 (86%)
		ZnF_U1	252..284	CDD:197732	22/31 (71%)
		C2H2 Zn finger	255..277	CDD:275371	15/21 (71%)
		ZnF_U1	368..396	CDD:197732	20/27 (74%)
		C2H2 Zn finger	368..390	CDD:275371	14/21 (67%)
		DZF	577..829	CDD:128842	136/262 (52%)
ZFR2	XP_011526133.1	ZnF_U1	271..300	CDD:197732	23/28 (82%)
		C2H2 Zn finger	273..295	CDD:275371	18/21 (86%)
		ZnF_U1	318..350	CDD:197732	22/31 (71%)
		C2H2 Zn finger	321..343	CDD:275371	15/21 (71%)
		ZnF_U1	467..498	CDD:197732	21/30 (70%)
		C2H2 Zn finger	470..492	CDD:275371	14/21 (67%)
		DZF	652..905	CDD:128842	136/257 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158133
Domainoid	1	1.000	267	1.000	Domainoid score	I1878
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	546	1.000	Inparanoid score	I1162
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	1	1.000	-	-		FOG0003979
OrthoInspector	1	1.000	-	-		otm40706
orthoMCL	1	0.900	-	-		OOG6_105636
Panther	1	1.100	-	-	O	PTHR45762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2736
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760