DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and zfr-1

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_490785.3	Gene:	zfr-1 / 190806	WormBaseID:	WBGene00022388	Length:	764	Species:	Caenorhabditis elegans

Alignment Length:	935	Identity:	271/935 - (28%)
Similarity:	395/935 - (42%)	Gaps:	275/935 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 YGGAAGAGAGATSGPGAGGYGGYGDYRSAMQYDATKTFYQQSPASY----NASGSTASVSKTHYS 109
            |||..||            ||.||:.::|.|     .:.||...:|    |...:....:.....
Worm     2 YGGYQGA------------YGAYGNQQAASQ-----PYQQQGQQNYYPGVNPYAANYGYAAAQLP 49

  Fly   110 APPVKNQVKGKMDKSNGGPKPPSSAPPAG--------------NNY---------SGYDTALYNA 151
            .||               |.||.:.|.||              |.|         .|||.|:||.
Worm    50 PPP---------------PPPPVADPYAGQFQTFPSQATKIAPNPYFKKPQNQQQQGYDAAVYNY 99

  Fly   152 ASMYVAQ--QHQGNPNQKPNGGANNWYQRKMGATIPGATAIRGMRPKAPPRPQQLHYCEVCKISC 214
            |.....:  :|.|...|...|..:|                            :.:|||||||||
Worm   100 AQQNTPKNWKHGGGGRQGRQGSGDN----------------------------KQYYCEVCKISC 136

  Fly   215 AGPQTYREHLEGQKHKKREASLKMSASANSATQNRGNNYHCELCDVTCTGTDAYAAHVRGAKHQK 279
            ||..||:||||||:|||:||..|....:.|..:|: .:|.|:||||||||.|.|:|||||.||.|
Worm   137 AGGITYKEHLEGQRHKKKEAMAKQGIPSTSLAKNK-LSYRCDLCDVTCTGQDTYSAHVRGGKHLK 200

  Fly   280 VVKLHQKLGKPIPSEEPKKM-----------------------GKI-------NFV--------- 305
            ..:||:|||||:|.:.|..:                       |||       |||
Worm   201 TAQLHKKLGKPVPEDVPTIIAPGADGPTETKAKPKWHQQALPGGKIVIGINTVNFVGGTKLNSTG 265

  Fly   306 -------PAAAGGAGVAKTEGGANESDAAGDLDDNLDDSLGENTDNIKPVGGEYIEEVKDEEGKI 363
                   ..||..:.|.:..|||..:......|:.|...:.  .:.::|||.|::.|.:|..||:
Worm   266 QLEEKKREVAAAVSSVGRKTGGAAATTTIEVEDEKLRAMIA--AEEVQPVGEEHVTEERDATGKL 328

  Fly   364 LSFNCKLCDCKFNDPNAKEMHMKGRRHRLQYKRKVQPDLVVDFKPTPRQRRLAEARANRAMMSSH 428
            :.|:||||||||:||||||:|:||||||:.|::|:.|.||||.||:  .:|..|.|.|: :.:.|
Worm   329 VQFHCKLCDCKFSDPNAKEIHIKGRRHRVSYRQKIDPTLVVDVKPS--NKRSQEKRKNQ-LPAVH 390

  Fly   429 RGGDDHDGGYWEEQRNRQYNEEYDYNNWMSRSFGGAQRFGRMGNGPPPHFGMMPGGNVRRPES-- 491
            .                                             ||.|...|......||.
Worm   391 E---------------------------------------------PPSFMKTPWFAPPAPEGRE 410

  Fly   492 ---TDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDKAEKPSE 553
               .|||....::|.:.|..|.:..:.|::|....:||.||                ||.|:...
Worm   411 FNIVDDRTINEKYAGLNPGVEFISNVDRLISDINESLKYVS----------------DKIERDVR 459

  Fly   554 KDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPTSGLLQRVA 618
            |...|  :..............|.:.|..|||.:|||..:.||...|:|:.|...|||||::::
Worm   460 KIPED--VVELPTTTTTTEQPPRTVLGCSRVGIIAKGTFIKGDRCAEVVLTCTPVPTSGLVEQI- 521

  Fly   619 NVLPDKLKEVAGDTQVNYRVEVNAEEAALIVLD----ESVSVKITLTSPLLRDAN----PGEAAT 675
                   :.:.|::..:..:|.:.|..:.:::.    .::..:|.:||.::|..:    .|.||.
Worm   522 -------RRLFGESTTSLTIEPDPESPSSLIVTANYFPNMKCRILITSAVVRKDDDSIVTGCAAD 579

  Fly   676 TDEGEGDSEFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQSLPQWSLE 740
            .|            .|:.|||.:|:.||:.:....|.||..|||:||||..:......|..:.:|
Worm   580 KD------------LCIYALASIRNTKWYDSHCQYLNSCQSVIRLLRDLRNKYPEVACLDDYKME 632

  Fly   741 LLVEKVISSAGFPISPGDCMRRIMEALSSGFLINGPGLLDPCEKDPTDALLELTKQEREDLTVSA 805
            |:|..:|.|:...:...|..:||:|||:||:|.:.. |.||||....:.|..||.:::..||..|
Worm   633 LIVSNIIDSSPMSLGLSDAFKRIVEALASGYLYSAI-LSDPCETSRPNVLDALTDEQKHSLTALA 696

  Fly   806 QLFLRYIAFRQIYKVLGMEPL----------PAMKFPMRPWRVNRKRRRSSGKAGGAPGTETESN 860
            |.|:|.|||.||:::||::.|          |.:|.|:                        |||
Worm   697 QNFVRQIAFNQIHEILGIDRLQDTIDLPEDAPMLKRPL------------------------ESN 737

  Fly   861 DIDETG---SDEKVAKKEGVGGTPA 882
            :..|..   .|..|:|||.:...||
Worm   738 ENAENAENLDDSPVSKKEKLDEEPA 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	24/30 (80%)
		C2H2 Zn finger	207..229	CDD:275371	18/21 (86%)
		ZnF_U1	252..284	CDD:197732	20/31 (65%)
		C2H2 Zn finger	255..277	CDD:275371	16/21 (76%)
		ZnF_U1	368..396	CDD:197732	22/27 (81%)
		C2H2 Zn finger	368..390	CDD:275371	18/21 (86%)
		DZF	577..829	CDD:128842	83/269 (31%)
zfr-1	NP_490785.3	ZnF_U1	125..157	CDD:197732	23/31 (74%)
		C2H2 Zn finger	129..151	CDD:275371	18/21 (86%)
		zf-met	175..198	CDD:372354	16/22 (73%)
		C2H2 Zn finger	176..198	CDD:275371	16/21 (76%)
		ZnF_U1	330..356	CDD:197732	20/25 (80%)
		C2H2 Zn finger	333..355	CDD:275371	18/21 (86%)
		DZF	481..720	CDD:128842	82/259 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156794
Domainoid	1	1.000	131	1.000	Domainoid score	I3231
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8009
Inparanoid	1	1.050	341	1.000	Inparanoid score	I1389
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28586
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	1	1.000	-	-		FOG0003979
OrthoInspector	1	1.000	-	-		oto19919
orthoMCL	1	0.900	-	-		OOG6_105636
Panther	1	1.100	-	-	LDO	PTHR45762
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3088
SonicParanoid	1	1.000	-	-		X2736
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840