DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and ADAD1

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_640336.1	Gene:	ADAD1 / 132612	HGNCID:	30713	Length:	576	Species:	Homo sapiens

Alignment Length:	351	Identity:	67/351 - (19%)
Similarity:	116/351 - (33%)	Gaps:	120/351 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 NGPPPHFGMMPGGNVRRPE--STDDRHAIARHAEIYPKEEEL--QTIQRIVSHTERALKLVSDAL 532
            :||||    .|...|...|  .....|...||.: |.|..::  :...:::|:....||..|...
Human   176 SGPPP----FPAEPVVLSELAYVSKVHYEGRHIQ-YAKISQIVKERFNQLISNRSEYLKYSSSLA 235

  Fly   533 AEQPSDAGAANKKDKAEKPSEKDGRDNQIFSFQKDADNGGN-------VVRILKGVMRVGYLAKG 590
            |.....||      :.|..:...|.    :::.:|....|.       ||...:.::|..| .:.
Human   236 AFIIERAG------QHEVVAIGTGE----YNYSQDIKPDGRVLHDTHAVVTARRSLLRYFY-RQL 289

  Fly   591 LLLHGDN--AVELVVLCAEKPTSGLLQRVANV--------LPDKLKEVAGDTQVNYRVEVNAEEA 645
            ||.:..|  .:|..:.|.| |||.||....|:        ||      .|..|:..::.:|....
Human   290 LLFYSKNPAMMEKSIFCTE-PTSNLLTLKQNINICLYMNQLP------KGSAQIKSQLRLNPHSI 347

  Fly   646 ALIVLDESVSVKITLTSPLLRDANPGEAATTDEGEGDSEFLPREPCLRALADLRHAKWFQARATG 710
            :....:|.:.:.:.:                 ||:
Human   348 SAFEANEELCLHVAV-----------------EGK------------------------------ 365

  Fly   711 LQSCVMVIRILRDLCQRVSSWQS---LPQWS--------LELLVEKVISSAGFPISPGDC----- 759
               ..:.:...:|...|:||..|   |.:|.        |...::.|..|: ..|..|:|
Human   366 ---IYLTVYCPKDGVNRISSMSSSDKLTRWEVLGVQGALLSHFIQPVYISS-ILIGDGNCSDTRG 426

  Fly   760 -----MRRIMEALSSG----FLINGP 776
                 .:|:.:||:|.    :|:|.|
Human   427 LEIAIKQRVDDALTSKLPMFYLVNRP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732
		C2H2 Zn finger	207..229	CDD:275371
		ZnF_U1	252..284	CDD:197732
		C2H2 Zn finger	255..277	CDD:275371
		ZnF_U1	368..396	CDD:197732
		C2H2 Zn finger	368..390	CDD:275371
		DZF	577..829	CDD:128842	42/235 (18%)
ADAD1	NP_640336.1	DSRM	97..162	CDD:214634
ADAD1	NP_640336.1	A_deamin	249..568	CDD:307992	47/267 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930