DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zn72D and Adarb2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_579836.1	Gene:	Adarb2 / 117088	RGDID:	621519	Length:	746	Species:	Rattus norvegicus

Alignment Length:	371	Identity:	75/371 - (20%)
Similarity:	131/371 - (35%)	Gaps:	76/371 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   508 EEELQTIQRIVSHTERALKLVSDALAEQPSD--AGAANKKDKAEKPSEKDGRDNQIFSFQKDADN 570
            |:.|.|....|........|.:..|  .|.|  .|.:....|.::|.|:              .|
  Rat    59 EDNLSTSSAEVKENRNVSNLGTRPL--PPGDWARGGSTPSVKRKRPLEE--------------GN 107

  Fly   571 GGNVVRI-------------LKGVMRVGYLAKGL---LLHGDNAVELVVLCAEKPTSGLLQRVAN 619
            ||:..::             ...::::..|..||   ::.....|...|.......:||......
  Rat   108 GGHFCKLQLIWKKLSWSMTPKNALVQLHELKPGLQYRMVSQTGPVHAPVFAVAVEVNGLTFEGTG 172

  Fly   620 VLPDKLKEVAGDTQVNYRVEV-NAEEAALIVLDESVSVKITLTS-------PLLRDANPGEAATT 676
            ....|.|..|.:..:...|:. ||.:|.| .:..|.|.....||       .|.::..|  ::..
  Rat   173 PTKKKAKMRAAEMALKSFVQFPNAFQAHL-AMGSSTSPCTDFTSDQADFPDTLFKEFEP--SSRN 234

  Fly   677 DEGEG----DSEFLP----REPCLRALADLR-HAKWFQAR----ATGLQSCVMVIRILRDLCQRV 728
            ::..|    |:|||.    |...|....||. .|...::|    |.|.::.|:|:..||...:.|
  Rat   235 EDFPGCCPVDTEFLSSAYRRGRLLYHTLDLMGQALPDRSRLAPGALGERNPVVVLNELRSGLRYV 299

  Fly   729 SSWQSLPQWSLELLVEKVI--------SSAGFPISPGDCMRRIMEALSSGFLINGPGLLDPCEK- 784
            ...::..:..::..|..|.        |.....::.|...:..::||   |.|..||.:....|
  Rat   300 CLSETAEKPRVKSFVMAVCVDGRTFEGSGRSKKLAKGQAAQAALQAL---FDIRLPGHIPSRSKS 361

  Fly   785 -----DPTDALLELTKQEREDLTVS-AQLFLRYIAFRQIYKVLGME 824
                 |..|::.:|..|:..:|||. ..::.|:.....|....|::
  Rat   362 NLLPQDFADSVSQLVTQKFRELTVGLTSVYARHKTLAGIVMTKGLD 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732
		C2H2 Zn finger	207..229	CDD:275371
		ZnF_U1	252..284	CDD:197732
		C2H2 Zn finger	255..277	CDD:275371
		ZnF_U1	368..396	CDD:197732
		C2H2 Zn finger	368..390	CDD:275371
		DZF	577..829	CDD:128842	60/300 (20%)
Adarb2	NP_579836.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		R-domain (ssRNA-binding). /evidence=ECO:0000250	23..35
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..105		11/47 (23%)
		DSRM	126..190	CDD:238007	10/63 (16%)
		DSRM	285..>332	CDD:214634	8/46 (17%)
		ADEAMc	367..743	CDD:214718	10/41 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840