DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Zn72D and Zfr2

DIOPT Version :9

Sequence 1:	NP_001261924.1	Gene:	Zn72D / 39764	FlyBaseID:	FBgn0263603	Length:	884	Species:	Drosophila melanogaster
Sequence 2:	NP_001030067.2	Gene:	Zfr2 / 103406	MGIID:	2143792	Length:	874	Species:	Mus musculus

Alignment Length:	997	Identity:	365/997 - (36%)
Similarity:	501/997 - (50%)	Gaps:	239/997 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MANNNYAGFNYGGTQYNTGQVS--YP-AVTNATYANAAAYQNAAVAAGQGGYGGAAGAGAGATSG 62
            ||.::.:|...|....::.|.|  :| ..|.|:|......:..:.|:       .|.|.|.....
Mouse     1 MAASSSSGLAQGTNPSSSTQSSSAFPLPATGASYTVQFTPKMESTAS-------LALAPASQLPA 58

  Fly    63 PGAGGYGGYGDYRSAMQYDATKTFYQQSPASYNASG---------STASVSKTHYSAPPVKNQVK 118
            ||.|...||...:.......|.:...:.|...:||.         ...:.|:|.....|.::..:
Mouse    59 PGGGVAVGYSCSQPQASQGPTSSSQPRGPVPTSASAHQEDGHSYREKVTKSRTDSRERPARSLCR 123

  Fly   119 -GKMDKS------NGGPKPPSSAPPAGNNYSGYDTALYNAASMYVAQQHQGNPNQKPNG-GANNW 175
             |...:|      :.||:.|   ||:...                |.|....|:..|.. |::.|
Mouse   124 PGPSSRSPDSDSVSPGPQRP---PPSSQR----------------APQKLQAPSPPPAPVGSDPW 169

  Fly   176 YQRKMGATIPGATA------IRGMRPKAPPRPQQLHYCEVCKISCAGPQTYREHLEGQKHKKREA 234
            ....:|...|..|:      .|..:|||.|||..:||||||::|||||||||:|||||||:|::|
Mouse   170 GGPVLGPWDPTFTSDALPFLDRLPKPKAGPRPPSMHYCEVCRVSCAGPQTYRDHLEGQKHRKKQA 234

  Fly   235 SLKMSASANSATQNRGN-NYHCELCDVTCTGTDAYAAHVRGAKHQKVVKLHQKLGKPIPSE-EPK 297
            :.:.|...:...  ||: :.||.||.|:|||.||||||:|||:||||.|||.:|||||||| .|:
Mouse   235 AQRTSTQPSGGP--RGSQSLHCGLCAVSCTGADAYAAHMRGARHQKVFKLHTRLGKPIPSEPTPR 297

  Fly   298 KM---------------------------GKINFVPAAAGGAGVAK------------------- 316
            .:                           |:    ||.|.|:..::
Mouse   298 SVTYTRGSDSTPETSVKHEAHARHSSHTQGR----PAPAKGSAASRKGPPELQTMHGRPGDRRPS 358

  Fly   317 ------TEGGANE-SDAAGDLDDNLDDSLGENTDNIKPVGGEYIEEVKDEEGKILSFNCKLCDCK 374
                  |.||..| |.::||:               .|||.||:|||..:|||::.|.||||:|.
Mouse   359 HFKVEATRGGPGEASGSSGDM---------------APVGTEYVEEVCSDEGKVIRFRCKLCECS 408

  Fly   375 FNDPNAKEMHMKGRRHRLQYKRKVQPDLVVDFKPT-PRQRRLAEARANRAMMSSHRGGDDHDGGY 438
            |||.||::||:.||||||||::||.|.|.|..:|: |.||.||: |..|               :
Mouse   409 FNDRNARDMHLTGRRHRLQYRKKVDPTLPVAARPSGPIQRVLAK-RLQR---------------H 457

  Fly   439 WEEQRNRQYNEEYDYNNWMSRSFGGAQRFGRMGNGPPPHF-GMMPG------------------- 483
            |::.:    .:..|...|.|......:...:....|.|.. ..:||
Mouse   458 WQQVQ----TQLEDTRRWDSELRQQEEHSRQPEETPQPQVEEQLPGLPAWALPAPTTRPGMATAR 518

  Fly   484 -GNVRRPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDALAEQPSDAGAANKKDK 547
             .:.|||||:||||.:.:||.|||.|||||.||..||||||||:||||.|||:.|..|..
Mouse   519 RQSGRRPESSDDRHVMCKHASIYPTEEELQAIQTAVSHTERALRLVSDTLAEESSQHGTL----- 578

  Fly   548 AEKPSEKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGLLLHGDNAVELVVLCAEKPTSG 612
            |..|.                       |:||||:|||.|||||:|.||::|:|.:||::|||..
Mouse   579 ASPPP-----------------------RMLKGVVRVGILAKGLVLRGDHSVQLTLLCSKKPTHS 620

  Fly   613 LLQRVANVLPDKLKEVAGDTQVNYRVEVNAEEAALIVL----DESVSVKITLTSPLLRDANPGEA 673
            ||||:...||.:|..||.|     :.||:::..|.||:    :..|.|.::.||||:|     |.
Mouse   621 LLQRIKQELPRELSIVAED-----KYEVSSDHDANIVISACVEPGVKVTVSATSPLMR-----ED 675

  Fly   674 ATTDEGEGDS-----EFLPREPCLRALADLRHAKWFQARATGLQSCVMVIRILRDLCQRVSSWQS 733
            .:..:|:.|:     :.|.||.||..||.|||||||||||:|||.||:|||:||:||:.:..|.:
Mouse   676 PSVKQGQQDALSDPEDVLDRERCLETLAALRHAKWFQARASGLQPCVIVIRVLRELCRCLPPWGA 740

  Fly   734 LPQWSLELLVEKVISSAGFPISPGDCMRRIMEALSSGFLI-NGPGLLDPCEKDPTDALLELTKQE 797
            ||.|::|||||||:|||..|:||||.|||::|.:::|.|: :||||.|||||.|.|||..:|.|:
Mouse   741 LPAWAMELLVEKVLSSAPRPLSPGDAMRRVLEYVATGALLTDGPGLQDPCEKGPQDALEPMTPQQ 805

  Fly   798 REDLTVSAQLFLRYIAFRQIYKVLGMEPLPAMKFPMRPWRVN---RKRRRSSGKAGGAPGTETES 859
            |||||.|||..||.:|||||:|||.||.||    |...:...   |||.|.:.:|
Mouse   806 REDLTASAQRALRLVAFRQIHKVLHMEQLP----PRTRFGAGARARKRMREASQA---------- 856

  Fly   860 NDIDETGSDEKVAKKEGVGGTP 881
                :.|:.|:...::|..|.|
Mouse   857 ----QEGTRERKRGRQGTAGLP 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zn72D	NP_001261924.1	ZnF_U1	205..236	CDD:197732	24/30 (80%)
		C2H2 Zn finger	207..229	CDD:275371	18/21 (86%)
		ZnF_U1	252..284	CDD:197732	22/31 (71%)
		C2H2 Zn finger	255..277	CDD:275371	16/21 (76%)
		ZnF_U1	368..396	CDD:197732	20/27 (74%)
		C2H2 Zn finger	368..390	CDD:275371	14/21 (67%)
		DZF	577..829	CDD:128842	139/261 (53%)
Zfr2	NP_001030067.2	CytochromB561_N	<72..>169	CDD:286826	19/115 (17%)
		ZnF_U1	205..232	CDD:197732	22/26 (85%)
		C2H2 Zn finger	207..253	CDD:275371	25/47 (53%)
		ZnF_U1	252..283	CDD:197732	22/30 (73%)
		C2H2 Zn finger	254..276	CDD:275371	16/21 (76%)
		ZnF_U1	399..430	CDD:197732	21/30 (70%)
		C2H2 Zn finger	402..424	CDD:275371	14/21 (67%)
		DZF	586..837	CDD:295427	139/264 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848520
Domainoid	1	1.000	268	1.000	Domainoid score	I1847
eggNOG	1	0.900	-	-		E1_KOG3792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1263
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276114at33208
OrthoFinder	1	1.000	-	-		FOG0003979
OrthoInspector	1	1.000	-	-		otm42780
orthoMCL	1	0.900	-	-		OOG6_105636
Panther	1	1.100	-	-	O	PTHR45762
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2736
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760