DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS9 and DCLRE1A

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001258745.1	Gene:	DCLRE1A / 9937	HGNCID:	17660	Length:	1040	Species:	Homo sapiens

Alignment Length:	597	Identity:	117/597 - (19%)
Similarity:	181/597 - (30%)	Gaps:	199/597 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CTARL---WKEKLHLL-------------PSPLS-EAFRAKKWRTIFSLKDVQGSLSKVTIMGYD 199
            ||:.:   :|...|.|             |||.| .:|...|...:.||::...|        |.
Human   161 CTSTIPFHYKRYTHFLLAQSRAGDHPFSSPSPASGGSFSETKSGVLCSLEERWSS--------YQ 217

  Fly   200 EKLDILGAFIATPVSSGYCLGSSNW----VLSTAHEKICYVSGSSTLTTHPRPINQSALKHADVL 260
            .:.|       ..||:...|.:..:    .|:.|.|||         :||.: .:|.||:..|.
Human   218 NQTD-------NSVSNDPLLMTQYFKKSPSLTEASEKI---------STHIQ-TSQQALQFTDF- 264

  Fly   261 IMTGLTQAPTVNPDTKLGELCMNVALTIRNNGSALIPCYPSGVVYDLFEC------LTQNLENAG 319
                      |..|..:|     |||.:.||...:....|..   |..:|      |..:.:...
Human   265 ----------VENDKLVG-----VALRLANNSEHINLPLPEN---DFSDCEISYSPLQSDEDTHD 311

  Fly   320 LNNVP------MFFISPVADSSL------------AYSNILAEWLSSAKQNKVYLPDDPFPHAFY 366
            ::..|      :||.....|.||            .:..:|.:...|..:...:|..|.:....|
Human   312 IDEKPDDSQEQLFFTESSKDGSLEEDDDSCGFFKKRHGPLLKDQDESCPKVNSFLTRDKYDEGLY 376

  Fly   367 LRNNKLKHYNHVFSEGFSK-----------DFRQPCVVFCGHPSL--RFGDAVH----------- 407
             |.|.|...:...|:....           ||    |:|  .|:|  :...:||
Human   377 -RFNSLNDLSQPISQNNESTLPYDLACTGGDF----VLF--PPALAGKLAASVHQATKAKPDEPE 434

  Fly   408 FIEMWGNNPNNSIIFTEPDFPYLQVLAPF-QPLAMKAFYCPIDTSLNYQQANKLIKELK------ 465
            |.....|.....|   |....|.||..|. :.|.:|.|...::..|:.|.....|::|.
Human   435 FHSAQSNKQKQVI---EESSVYNQVSLPLVKSLMLKPFESQVEGYLSSQPTQNTIRKLSSENLNA 496

  Fly   466 ---------------------------PNVLVIP-EAYTKPHPSAPNLFIEQPDKKII-TFKCGE 501
                                       .|:...| ..|.|..||........|..|:: ....|.
Human   497 KNNTNSACFCRKALEGVPVGKATILNTENLSSTPAPKYLKILPSGLKYNARHPSTKVMKQMDIGV 561

  Fly   502 IIRLPLKRKLDRIYITSEL----------------------AQK-ISPKEVAAGVTFST-----L 538
            ...||.|||.:::...|.|                      |:| :|..|..|.....:     |
Human   562 YFGLPPKRKEEKLLGESALEGINLNPVPSPNQKRSSQCKRKAEKSLSDLEFDASTLHESQLSVEL 626

  Fly   539 TGVLQVKDKVHCIQPCADSVKDETISSNSAPTKEDVLKNVKYEYGSIDVDAVMKKLAQDGF--SN 601
            :.....:.|..|       .|..::...:...:.|.|.|.:.|..::....|..|.|..|.  .|
Human   627 SSERSQRQKKRC-------RKSNSLQEGACQKRSDHLINTESEAVNLSKVKVFTKSAHGGLQRGN 684

  Fly   602 IKL---DRTGGA 610
            .|:   ...||:
Human   685 KKIPESSNVGGS 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	30/132 (23%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983	30/171 (18%)
DCLRE1A	NP_001258745.1	Nuclear localization region	1..190		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	15..76
		Nuclear focus formation	396..614		43/226 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	582..602		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..651		4/34 (12%)
		SNM1A-like_MBL-fold	689..844	CDD:293856	2/8 (25%)
		DRMBL	914..1019	CDD:311461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900