Protein Alignment IntS9 and YSH1

DIOPT Version :10

• Sequence 1: NP_648838.3
• Gene: IntS9 / 39763
• FlyBaseID: FBgn0036570
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_013379.1
• Gene: YSH1 / 850983
• SGDID: S000004267
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 738
• Identity: 148/738 - (20%)
• Similarity: 281/738 - (38%)
• Gaps: 217/738 - (29%)

  Fly     7 SGDLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKD 71
            |.::.:.|:|:.:||..:|||.|:.          |..|.|  ::||
Yeast    17 SNEVGRSCHILQYKGKTVMLDAGIH----------PAYQGL--ASLP------------------ 51

  Fly    72 CCGRVFVDSTPEFNLPMDKMLDFSEVDVILISNYL--NMLALPYITENTGFKGKVYATEPTLQIG 134
                 |.|   ||        |.|:||::|||::.  :..:|||:.:.|.|:|:|:.|.||..|.
Yeast    52 -----FYD---EF--------DLSKVDILLISHFHLDHAASLPYVMQRTNFQGRVFMTHPTKAIY 100

  Fly   135 RFFLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVTIMGYD 199
            |:.|.:.|....:..                   |.:....|...:||.:|:..|..|:..:.|.
Yeast   101 RWLLRDFVRVTSIGS-------------------SSSSMGTKDEGLFSDEDLVDSFDKIETVDYH 146

  Fly   200 EKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSALK--HADVLIM 262
            ..:|:.|... |...:|:.||::.:.:..|..::.:....|...  .|.:|.:.:.  .::|||:
Yeast   147 STVDVNGIKF-TAFHAGHVLGAAMFQIEIAGLRVLFTGDYSREV--DRHLNSAEVPPLSSNVLIV 208

  Fly   263 TG----LTQAPTVNPDTKLGELCMNVALTIRNNGSALIPCYPSG----VVYDLFECLTQNLENAG 319
            ..    .|..|.:|.:.||.:|   :..|:...|..|:|.:..|    ::..|.|..:|:.:..|
Yeast   209 ESTFGTATHEPRLNRERKLTQL---IHSTVMRGGRVLLPVFALGRAQEIMLILDEYWSQHADELG 270

  Fly   320 LNNVPMFFISPVADSSLA----YSNILAEWLSSA---KQNKVYLPDDPFPHAFYLRNNKLKHYNH 377
            ...||:|:.|.:|...::    |.|::.:.:...   .|...::    |.:..||||
Yeast   271 GGQVPIFYASNLAKKCMSVFQTYVNMMNDDIRKKFRDSQTNPFI----FKNISYLRN-------- 323

  Fly   378 VFSEGFSKDFRQ--PCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFT--------------EPD 426
                  .:||:.  |.|:......|:.|.:...:|.|.....|.::.|              |||
Yeast   324 ------LEDFQDFGPSVMLASPGMLQSGLSRDLLERWCPEDKNLVLITGYSIEGTMAKFIMLEPD 382

  Fly   427 -FPYL---QVLAPFQPLAMKAFYCPID-----TSLNYQQANKLIKELK-PNVLVI-----PEAYT 476
             .|.:   ::..|.:        |.::     ..:::|:..:.|:::. ||::::     |....
Yeast   383 TIPSINNPEITIPRR--------CQVEEISFAAHVDFQENLEFIEKISAPNIILVHGEANPMGRL 439

  Fly   477 KPHPSAPNLFIEQPDKKIITFKCGEIIRLPLK-----------------RKLDRIYITSELAQKI 524
            |....:....::..|.::..|.....:.:.|:                 .|.:.:.|..|:|.||
Yeast   440 KSALLSNFASLKGTDNEVHVFNPRNCVEVDLEFQGVKVAKAVGNIVNEIYKEENVEIKEEIAAKI 504

  Fly   525 SP----------KEVAAGVTFS------TLTGVLQVKDKVHCIQPCADSVKDE---TISSNSAPT 570
            .|          .:...|:...      .::|:|...||...:...:.|...|   .:|:.....
Yeast   505 EPIKEENEDNLDSQAEKGLVDEEEHKDIVVSGILVSDDKNFELDFLSLSDLREHHPDLSTTILRE 569

  Fly   571 KEDVLKNVKYE---------YGSIDV----DAV------MKKLAQDGFSNIKLDRTG-------G 609
            ::.|..|.|.|         :|..:|    |.|      :|:.::|..:|     ||       |
Yeast   570 RQSVRVNCKKELIYWHILQMFGEAEVLQDDDRVTNQEPKVKEESKDNLTN-----TGKLILQIMG 629

  Fly   610 ALTLNLVNEDTVIKFED---NET 629
            .:.|.:||...|:::..   |:|
Yeast   630 DIKLTIVNTLAVVEWTQDLMNDT 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:451500	60/260 (23%)
		Beta-Casp	304..428	CDD:214983	30/147 (20%)
YSH1	NP_013379.1	CPSF3-like_MBL-fold	9..210	CDD:293850	60/260 (23%)
		YSH1	14..432	CDD:440849	108/511 (21%)
		CPSF73-100_C	533..777	CDD:463330	27/125 (22%)