DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment IntS9 and DCLRE1C

DIOPT Version :9

Sequence 1:NP_648838.3 Gene:IntS9 / 39763 FlyBaseID:FBgn0036570 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_001029027.1 Gene:DCLRE1C / 64421 HGNCID:17642 Length:692 Species:Homo sapiens


Alignment Length:723 Identity:128/723 - (17%)
Similarity:212/723 - (29%) Gaps:303/723 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 TGFKGKVYATEPTLQIGRFFLEEL-----------VDYIEVSPKACTARLWKE---KLHLLPSPL 168
            :.|:|:: |..||:.|.||..|.|           .|::: ..:|.|.:...|   |::|..||:
Human     2 SSFEGQM-AEYPTISIDRFDRENLRARAYFLSHCHKDHMK-GLRAPTLKRRLECSLKVYLYCSPV 64

  Fly   169 -------SEAFRAKKWRTIFSLKDVQGSLSKVTIMGYDEKLDILGAFIATPVSSGYCLGSSNWVL 226
                   |..:|..|.|.|....:....:|.|     ||........:.|.:.:|:|.||..::.
Human    65 TKELLLTSPKYRFWKKRIISIEIETPTQISLV-----DEASGEKEEIVVTLLPAGHCPGSVMFLF 124

  Fly   227 STAHEKICYV-----------------SGS----------STLTTHPR----PINQSALKHADVL 260
            ...:..:.|.                 ||.          .|....||    |..:..|.....|
Human   125 QGNNGTVLYTGDFRLAQGEAARMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLEL 189

  Fly   261 IMTGLTQAP----TVNPDTKLGELCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNL-ENAG- 319
            :.:.:|::|    .:|.....|                             :|.|..|| |..| 
Human   190 VRSWITRSPYHVVWLNCKAAYG-----------------------------YEYLFTNLSEELGV 225

  Fly   320 ---LNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHVFSE 381
               :|.:.||...|         .||.           :|..|        ||.::....|..:|
Human   226 QVHVNKLDMFRNMP---------EILH-----------HLTTD--------RNTQIHACRHPKAE 262

  Fly   382 GFSKDFRQPCVVFCGHPSLRFGDAVHFIE-----MW---GNNPNNSIIFT-EPDF---------- 427
            .:.:..:.||.:     :.|....:|.|.     ||   .:...|.|:.| |..:          
Human   263 EYFQWSKLPCGI-----TSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYRACFSFHSSY 322

  Fly   428 ----PYLQVLAPFQPLAMKAF--YCPIDTSLNYQQANKLIKELKP-------------------- 466
                .:|..|.|     :.|:  ..|:.|::     :|:::.|||                    
Human   323 SEIKDFLSYLCP-----VNAYPNVIPVGTTM-----DKVVEILKPLCRSSQSTEPKYKPLGKLKR 377

  Fly   467 -----------------NVLVIPEAYTKPHPSA--PNLFI------EQPDKKIITFKC------- 499
                             :.|.||..:..|:|..  |.:|.      :||:|...|..|       
Human   378 ARTVHRDSEEEDDYLFDDPLPIPLRHKVPYPETFHPEVFSMTAVSEKQPEKLRQTPGCCRAECMQ 442

  Fly   500 -------------------------------GEIIRLPLKRKLD------RIY------ITSELA 521
                                           |.::.|   :|.|      .::      ||.|..
Human   443 SSRFTNFVDCEESNSESEEEVGIPASLQGDLGSVLHL---QKADGDVPQWEVFFKRNDEITDESL 504

  Fly   522 QKISPKEVAAGVTF----------STLTGVLQVKDKVHCIQPCA---DSVKDETISSNSAPTKED 573
            :......||.|...          ||...........|..:..:   ||..|..:.|:......|
Human   505 ENFPSSTVAGGSQSPKLFSDSDGESTHISSQNSSQSTHITEQGSQGWDSQSDTVLLSSQERNSGD 569

  Fly   574 VLKNVKYEYGSIDVDAVMKKLAQ-------DGFSNIK--------LDRTGGALTLNLVNEDTVIK 623
            :....|.:|.....:.:...|.:       |.:|::|        :..||...||:         
Human   570 ITSLDKADYRPTIKENIPASLMEQNVICPKDTYSDLKSRDKDVTIVPSTGEPTTLS--------- 625

  Fly   624 FEDNETHI 631
               :||||
Human   626 ---SETHI 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IntS9NP_648838.3 metallo-hydrolase-like_MBL-fold 1..264 CDD:304873 41/197 (21%)
Beta-Casp 304..428 CDD:214983 29/151 (19%)
DCLRE1CNP_001029027.1 artemis-SNM1C-like_MBL-fold 1..171 CDD:293855 36/175 (21%)
DRMBL 239..343 CDD:284854 24/141 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 504..555 8/50 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..664
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1236
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.