Protein Alignment IntS9 and INTS9

DIOPT Version :10

• Sequence 1: NP_648838.3
• Gene: IntS9 / 39763
• FlyBaseID: FBgn0036570
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_001349967.1
• Gene: INTS9 / 55756
• HGNCID: 25592
• Length: 676
• Species: Homo sapiens
• Alignment Length: 681
• Identity: 345/681 - (50%)
• Similarity: 472/681 - (69%)
• Gaps: 32/681 - (4%)

  Fly     1 MRLYCLSGDLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQM 65
            |:||||||....||.::.||...|||||||...:.|||||||.|||.:.||||.: ..:|.:..:
Human     1 MKLYCLSGHPTLPCNVLKFKSTTIMLDCGLDMTSTLNFLPLPLVQSPRLSNLPGW-SLKDGNAFL 64

  Fly    66 DGELKDCCGRVFVDSTPEFNLPMDKMLDFSEVDVILISNYLNMLALPYITENTGFKGKVYATEPT 130
            |.|||:|.|.|||||.|||.||..:::|.|.|||||||||..|:|||||||:|||.|.|||||||
Human    65 DKELKECSGHVFVDSVPEFCLPETELIDLSTVDVILISNYHCMMALPYITEHTGFTGTVYATEPT 129

  Fly   131 LQIGRFFLEELVDYIEVSPKACTARLWKEK--LHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKV 193
            :||||..:||||::||..|||.:|.|||.|  ..||||||.:|.....||..:::::|..:|||:
Human   130 VQIGRLLMEELVNFIERVPKAQSASLWKNKDIQRLLPSPLKDAVEVSTWRRCYTMQEVNSALSKI 194

  Fly   194 TIMGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSALKHAD 258
            .::||.:|:::.||...||:||||.||||||::.:.:||:.||||||.|||||:|::|::||::|
Human   195 QLVGYSQKIELFGAVQVTPLSSGYALGSSNWIIQSHYEKVSYVSGSSLLTTHPQPMDQASLKNSD 259

  Fly   259 VLIMTGLTQAPTVNPDTKLGELCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLENAGLNNV 323
            ||::|||||.||.|||..:||.|.|:|||:||.|:.|:|||||||:|||.|||.|.:::|||::|
Human   260 VLVLTGLTQIPTANPDGMVGEFCSNLALTVRNGGNVLVPCYPSGVIYDLLECLYQYIDSAGLSSV 324

  Fly   324 PMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHVFSEGFSKDFR 388
            |::||||||:|||.:|.|.||||...||:|||||:.|||||..::.||||||..:..: ||.|||
Human   325 PLYFISPVANSSLEFSQIFAEWLCHNKQSKVYLPEPPFPHAELIQTNKLKHYPSIHGD-FSNDFR 388

  Fly   389 QPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYLQVLAPFQPLAMKAFYCPIDTSLN 453
            ||||||.|||||||||.|||:|:||.:..|::|||||||.||:.|||:||||||..||||||.||
Human   389 QPCVVFTGHPSLRFGDVVHFMELWGKSSLNTVIFTEPDFSYLEALAPYQPLAMKCIYCPIDTRLN 453

  Fly   454 YQQANKLIKELKPNVLVIPEAYTKPHPSAP---NLFIE-QPDKKIITFKCGEIIRLPLKRKLDRI 514
            :.|.:||:||::|..:|.||.||:|.|:..   :|.|: ||  ..::::..|::.||.||:.::|
Human   454 FIQVSKLLKEVQPLHVVCPEQYTQPPPAQSHRMDLMIDCQP--PAMSYRRAEVLALPFKRRYEKI 516

  Fly   515 YITSELAQKISPKEVAAGVTFSTLTGVLQVKDKVHCIQP---------------CADSVKD---- 560
            .|..|||..:.|.|:..|::.:|::.||..||..|.:||               .:|.|.|
Human   517 EIMPELADSLVPMEIKPGISLATVSAVLHTKDNKHLLQPPPRPAQPTSGKKRKRVSDDVPDCKVL 581

  Fly   561 ETISSNSAPTKEDV--LKNVKYEYGSIDVDAVMKKLAQDGFSNIKLDRTGGALTLNLVNEDTVIK 623
            :.:.|.|.|.::.|  |:.:. :..|:....:...|.|.|||:||::.|.....:.|...:|:|:
Human   582 KPLLSGSIPVEQFVQTLEKIS-QMCSLPSPPLSFLLEQHGFSDIKVEDTAKGHIVLLQEAETLIQ 645

  Fly   624 FEDNETHIICGGKPTTRLKLRDTIMKCLQSF 654
            .|::.|||||......|::|||.::|.||.|
Human   646 IEEDSTHIICDNDEMLRVRLRDLVLKFLQKF 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:451500	147/264 (56%)
		Beta-Casp	304..428	CDD:214983	78/123 (63%)
INTS9	NP_001349967.1	Int9-like_MBL-fold	1..265	CDD:293852	147/264 (56%)
		Beta-Casp	307..425	CDD:214983	74/118 (63%)