DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS9 and ints11

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001018457.1	Gene:	ints11 / 553648	ZFINID:	ZDB-GENE-050522-13	Length:	598	Species:	Danio rerio

Alignment Length:	672	Identity:	129/672 - (19%)
Similarity:	247/672 - (36%)	Gaps:	189/672 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCC 73
            |:.:.|.:::..|..||||||         :.:.|....::   |:|
Zfish    14 DVGRSCILVSIGGKNIMLDCG---------MHMGFNDDRRF---PDF------------------ 48

  Fly    74 GRVFVDSTPEFNLPMDKMLDFSEVDVILISNYL--NMLALPYITENTGFKGKVYATEPTLQIGRF 136
                     .:.....::.:|  :|.::||::.  :..||||::|..|:.|.:|.|.||..|...
Zfish    49 ---------SYITQNGRLTEF--LDCVIISHFHLDHCGALPYMSEMVGYDGPIYMTHPTKAICPI 102

  Fly   137 FLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRA----KKWRT-IFSLKDVQGSLSKVTIM 196
            .||:                               ||.    ||..| .|:.:.::..:.||..:
Zfish   103 LLED-------------------------------FRKITVDKKGETNFFTSQMIKDCMKKVVPL 136

  Fly   197 G------YDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSALK 255
            .      .|::|:|...:      :|:.||::...:....|.:.| :|...:|. .|.:..:.:.
Zfish   137 NLHQTVQVDDELEIKAYY------AGHVLGAAMVQIKVGSESVVY-TGDYNMTP-DRHLGAAWID 193

  Fly   256 --HADVLIMTGLTQAPTVNPDTKLGE--LCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLE 316
              ..|:||... |.|.|:....:..|  ....|..|:...|..|||.:..|...:|...|....|
Zfish   194 KCRPDILISES-TYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWE 257

  Fly   317 NAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHVFSE 381
            ...| ..|::|.:.:.:.:..|..:...| ::.|..|.::..:.|         :.||.. .|..
Zfish   258 RMNL-KAPIYFSTGLTEKANHYYKLFITW-TNQKIRKTFVQRNMF---------EFKHIK-AFDR 310

  Fly   382 GFSKDFRQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYL-----QVLAPFQPLAM 441
            .:: |...|.|||.....|..|.::...:.|..|..|.:|.  |.:...     ::|...:.|.|
Zfish   311 SYA-DNPGPMVVFATPGMLHAGQSLQIFKKWAGNEKNMVIM--PGYCVQGTVGHKILNGQKKLEM 372

  Fly   442 KAFYCPIDTSLNYQQAN-----------KLIKELKP-NVLVIPEAYTKPHPSAPNL-FIEQPDKK 493
            :. ...:|..|..:..:           :||:..:| |:|::       |..|..: |::...::
Zfish   373 EG-RATLDVKLQVEYMSFSAHADAKGIMQLIRMAEPRNMLLV-------HGEAKKMEFLKDKIEQ 429

  Fly   494 IITFKC-----GE---IIRLPLKRKLDRIYITSELAQKISPKEVAAGVTF------STLTGVLQV 544
            ..:..|     ||   |:..|        .:..:::..:..:|:|.|...      .|:.|.|.:
Zfish   430 EFSISCFMPANGETTTIVTNP--------SVPVDISLNLLKREMALGGPLPDAKRPRTMHGTLIM 486

  Fly   545 KD-KVHCIQP-----------------CADSVKD-----ETISSNSAPTKEDVLKNVKYEY---G 583
            || .:..:.|                 |...:.|     :|:|......| .|||:...::   |
Zfish   487 KDNSLRLVSPEQALKELGLNEHQLRFTCRVQLHDPHSDTDTLSRIYTHLK-SVLKSYSIQHVPDG 550

  Fly   584 SIDVDAVMKKLAQDGFS-NIKL 604
            ::.|::::.|:...... |:|:
Zfish   551 TVIVESIVIKVTSSAEEPNLKV 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	52/269 (19%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983	26/123 (21%)
ints11	NP_001018457.1	YSH1	4..442	CDD:224157	103/531 (19%)
		INTS11-like_MBL-fold	6..204	CDD:293849	52/269 (19%)
		HXHXDH motif	68..73		0/4 (0%)
		Beta-Casp	245..363	CDD:214983	26/132 (20%)
		RMMBL	377..416	CDD:284853	8/45 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910