DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS9 and INTS11

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	XP_011539949.1	Gene:	INTS11 / 54973	HGNCID:	26052	Length:	660	Species:	Homo sapiens

Alignment Length:	688	Identity:	142/688 - (20%)
Similarity:	245/688 - (35%)	Gaps:	204/688 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCC 73
            |:.:.|.:::..|..:|||||         :.:.|....::   |:|
Human    74 DVGRSCILVSIAGKNVMLDCG---------MHMGFNDDRRF---PDF------------------ 108

  Fly    74 GRVFVDSTPEFNLPMDKMLDFSEVDVILISNYL--NMLALPYITENTGFKGKVYATEPTLQIGRF 136
                     .:.....::.||  :|.::||::.  :..||||.:|..|:.|.:|.|.||..|...
Human   109 ---------SYITQNGRLTDF--LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPI 162

  Fly   137 FLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVT------I 195
            .||   ||.::                       |...|.....|:.:.::..:.||.      .
Human   163 LLE---DYRKI-----------------------AVDKKGEANFFTSQMIKDCMKKVVAVHLHQT 201

  Fly   196 MGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSAL-KHADV 259
            :..|::|:|...:      :|:.||::.:.:....|.:.| :|...:|. .|.:..:.: |....
Human   202 VQVDDELEIKAYY------AGHVLGAAMFQIKVGSESVVY-TGDYNMTP-DRHLGAAWIDKCRPN 258

  Fly   260 LIMTGLTQAPTVNPDTKLGE--LCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLENAGLNN 322
            |::|..|.|.|:....:..|  ....|..|:...|..|||.:..|...:|...|....|...| .
Human   259 LLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNL-K 322

  Fly   323 VPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHVFSEGFSKDF 387
            ||::|.:.:.:.:..|..:...| ::.|..|.::..:.|         :.||.. .|...|: |.
Human   323 VPIYFSTGLTEKANHYYKLFIPW-TNQKIRKTFVQRNMF---------EFKHIK-AFDRAFA-DN 375

  Fly   388 RQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIF-----------------TEPDFPYLQVLAP 435
            ..|.|||.....|..|.::.....|..|..|.:|.                 .:.:....|||
Human   376 PGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVGHKILSGQRKLEMEGRQVL-- 438

  Fly   436 FQPLAMKAFYCPIDTSLNYQQANKLIKELKP-NVLVIPEAYTKPHPSAPNL-FIEQPDKKIITFK 498
              .:.|:..|.......:.:...:|:.:.:| :||::       |..|..: |::|..::.:...
Human   439 --EVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLV-------HGEAKKMEFLKQKIEQELRVN 494

  Fly   499 C-----GEIIRLP-------------LKR----------KLDRI-------------YITSELAQ 522
            |     ||.:.||             |||          |..|:             .::||.|.
Human   495 CYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLHGTLIMKDSNFRLVSSEQAL 559

  Fly   523 K--------------------ISPKEVAAGVTFSTLTGVLQVKDKVHCIQPCAD-SVKDETISSN 566
            |                    ...:|.|..| :|.|..||    |.||:|...| ||..|::...
Human   560 KELGLAEHQLRFTCRVHLHDTRKEQETALRV-YSHLKSVL----KDHCVQHLPDGSVTVESVLLQ 619

  Fly   567 SAPTKED-----VLKNVKY---EYGSIDVDAVMKKLAQ 596
            :|...||     :|.:..|   |.||.....:.|.|.|
Human   620 AAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQ 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	50/263 (19%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983	27/140 (19%)
INTS11	XP_011539949.1	YSH1	70..504	CDD:224157	105/528 (20%)
		INTS11-like_MBL-fold	70..264	CDD:293849	51/264 (19%)
		Beta-Casp	305..423	CDD:214983	27/130 (21%)
		RMMBL	436..476	CDD:284853	10/50 (20%)
		RhoGAP	<468..>540	CDD:295372	16/78 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810