DRSC/TRiP Functional Genomics Resources

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Protein Alignment IntS9 and CPSF2

DIOPT Version :9

Sequence 1:NP_648838.3 Gene:IntS9 / 39763 FlyBaseID:FBgn0036570 Length:654 Species:Drosophila melanogaster
Sequence 2:NP_001309201.1 Gene:CPSF2 / 53981 HGNCID:2325 Length:782 Species:Homo sapiens


Alignment Length:756 Identity:157/756 - (20%)
Similarity:263/756 - (34%) Gaps:245/756 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MRLYCLSG--DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDP 63
            ::|..|||  :.:..||::.....|.:||||..|.     ..:..:.||           |.|  
Human     5 IKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEH-----FSMDIIDSL-----------RKH-- 51

  Fly    64 QMDGELKDCCGRVFVDSTPEFNLPMDKMLDFSEVDVILIS--NYLNMLALPYITENTGFKGKVYA 126
                                          ..::|.:|:|  :.|::.||||.....|....:||
Human    52 ------------------------------VHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYA 86

  Fly   127 TEPTLQIGRFFLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLS 191
            |.|..::|:.|:.:|.                :..|     .:|.|      |:|:|.||..:..
Human    87 TIPVYKMGQMFMYDLY----------------QSRH-----NTEDF------TLFTLDDVDAAFD 124

  Fly   192 KVTIMGYDEKLDILG---AFIATPVSSGYCLGSSNW-VLSTAHEKICYVSGSSTLTTHPRPINQS 252
            |:..:.:.:.:::.|   ....||:.:|:.:|.:.| ::....|:|.|....:    |.|.|:.:
Human   125 KIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFN----HKREIHLN 185

  Fly   253 A----LKHADVLIMTGLTQAPTVNPDTKL--GELCMNVALTIRNNGSALIPCYPSGVVYDLFECL 311
            .    :.....|::|....|..|.|..|.  .:|..||..|:|.:|:.||....:|.|.:|.:.|
Human   186 GCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLL 250

  Fly   312 TQ--NLENAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKH 374
            .|  ..::|||....:..::.|:.:.:.:|....||:|           |.....|..:.|....
Human   251 DQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMS-----------DKLMRCFEDKRNNPFQ 304

  Fly   375 YNHV-FSEGFSKDFR--QPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYLQVLAPF 436
            :.|: ...|.|...|  .|.||....|.|..|.:......|..:|.||||.|....|  ..||.|
Human   305 FRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTP--GTLARF 367

  Fly   437 QPLAMKAFYCPID------TSL--------------NYQQANKLIKELKPNV------------- 468
            .          ||      |.:              .|.:..||.||....:             
Human   368 L----------IDNPSEKITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDE 422

  Fly   469 ------LVIPEAYTKPHP-------SAPNLFIEQ----------PDKKIITFKCGEIIRLPLKRK 510
                  :..|.|:...|.       |....|.:|          |:::|...:.||||: |....
Human   423 SDIEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIK-PEDFL 486

  Fly   511 LDRIYITSELAQKISPKEVAAGVT-----------------FSTLTGVLQVKDKVHCI----QPC 554
            :..:..|.|...|:.     :|:|                 .|| |..:::|.:|..|    :..
Human   487 VPELQATEEEKSKLE-----SGLTNGDEPMDQDLSDVPTKCIST-TESIEIKARVTYIDYEGRSD 545

  Fly   555 ADSVKD--------ETISSNSAPTKEDVLKNVKYEYGSIDVDAVMKKLAQDGFSNIKLDRTGGAL 611
            .||:|.        :.|..:..|.....|......:|..|:...|.||.:      .:|.|    
Human   546 GDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHE------TVDAT---- 600

  Fly   612 TLNLVNEDTVIKFEDNETHIICGGKPTTRLKLRDTIMKCLQ 652
                           :||||.       :::|:|:::..||
Human   601 ---------------SETHIY-------QVRLKDSLVSSLQ 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IntS9NP_648838.3 metallo-hydrolase-like_MBL-fold 1..264 CDD:304873 54/274 (20%)
Beta-Casp 304..428 CDD:214983 32/128 (25%)
CPSF2NP_001309201.1 CPSF2-like_MBL-fold 7..204 CDD:293851 55/275 (20%)
Beta-Casp 243..368 CDD:214983 35/137 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..449 3/41 (7%)
RMMBL 529..591 CDD:400070 11/61 (18%)
CPSF100_C 608..779 CDD:404222 4/12 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1236
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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