DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS9 and Cpsf100

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_651658.1	Gene:	Cpsf100 / 43426	FlyBaseID:	FBgn0027873	Length:	756	Species:	Drosophila melanogaster

Alignment Length:	726	Identity:	151/726 - (20%)
Similarity:	247/726 - (34%)	Gaps:	269/726 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLYCLSG--DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDP 63
            ::|:.:||  |.:.||||:....:||:||||..|:...||:.
  Fly     5 IKLHTISGAMDESPPCYILQIDDVRILLDCGWDEKFDANFIK----------------------- 46

  Fly    64 QMDGELKDCCGRVFVDSTPEFNLPMDKMLDFSEVDVILIS--NYLNMLALPYITENTGFKGKVYA 126
                |||                     .....:|.:|:|  :..::.||||:....|....:||
  Fly    47 ----ELK---------------------RQVHTLDAVLLSHPDAYHLGALPYLVGKLGLNCPIYA 86

  Fly   127 TEPTLQIGRFFLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLS 191
            |.|..::|:.|:.:|  |:.               |.......          :|||.||..:..
  Fly    87 TIPVFKMGQMFMYDL--YMS---------------HFNMGDFD----------LFSLDDVDTAFE 124

  Fly   192 KVTIMGYDEKLDI----LGAFIATPVSSGYCLGSSNW-VLSTAHEKICYVSGSSTLTTHPRPINQ 251
            |:|.:.|::.:.:    .|..| ||:::|:.:|.:.| ::....|.|.|    :|...|.:..:.
  Fly   125 KITQLKYNQTVSLKDKGYGISI-TPLNAGHMIGGTIWKIVKVGEEDIVY----ATDFNHKKERHL 184

  Fly   252 SA-----LKHADVLIMTGLT----QAPTVNPDTKLGELCMNVALTIRNNGSALIPCYPSGVVYDL 307
            |.     |:...:||.....    ||.....|.|   |..|:..|:||||:.||....:|.|.:|
  Fly   185 SGCELDRLQRPSLLITDAYNAQYQQARRRARDEK---LMTNILQTVRNNGNVLIAVDTAGRVLEL 246

  Fly   308 FECLTQNLEN--AGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFY-LRN 369
            ...|.|..:|  :||....:..::.|:.:.:.::....||:|           |....||. .||
  Fly   247 AHMLDQLWKNKESGLMAYSLALLNNVSYNVIEFAKSQIEWMS-----------DKLTKAFEGARN 300

  Fly   370 N--KLKHYN--HVFSEGFSKDFRQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYL 430
            |  :.||..  |..::.: |....|.||....|.|..|........|.:|.|||||.|....|
  Fly   301 NPFQFKHIQLCHSLADVY-KLPAGPKVVLASTPDLESGFTRDLFVQWASNANNSIILTTRTSP-- 362

  Fly   431 QVLAPFQPLAMKAFYCPIDTSLNYQQANKLIKELKPNVLVIPEAYTKPHPSAPNLFIEQPDKKII 495
                  ..|||                 :|::...|
  Fly   363 ------GTLAM-----------------ELVENCAP----------------------------- 375

  Fly   496 TFKCGEIIRLPLKRKLD------RIYITSELAQKISP------------KEVAAGVTFSTLTGVL 542
                |:.|.|.::|::|      ..|:.:: .:|::|            .|....:..|.:||..
  Fly   376 ----GKQIELDVRRRVDLEGAELEEYLRTQ-GEKLNPLIVKPDVEEESSSESEDDIEMSVITGKH 435

  Fly   543 QV--------------------------KDKVHCIQ----------PCADSVKDETISSNSAPTK 571
            .:                          ::||.|.:          ..||:...|.:     |.:
  Fly   436 DIVVRPEGRHHSGFFKSNKRHHVMFPYHEEKVKCDEYGEIINLDDYRIADATGYEFV-----PME 495

  Fly   572 EDVLKNVKYEYGSIDVDAVMKKLAQDGFSNIKLDRTGGALTLNLVNEDTVIKFEDNETHIICGGK 636
            |...:|||.|...|..:.               ...||.:              ||:..::  .|
  Fly   496 EQNKENVKKEEPGIGAEQ---------------QANGGIV--------------DNDVQLL--EK 529

  Fly   637 PTTRLKLRDTI 647
            ||..:..|.||
  Fly   530 PTKLISQRKTI 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	61/276 (22%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983	35/130 (27%)
Cpsf100	NP_651658.1	CPSF2-like_MBL-fold	7..204	CDD:293851	61/276 (22%)
		YSH1	19..400	CDD:224157	118/533 (22%)
		Beta-Casp	243..369	CDD:214983	39/162 (24%)
		RMMBL	538..577	CDD:284853	2/3 (67%)
		CPSF100_C	617..753	CDD:290038
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440175
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740