DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS9 and Snm1

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_649548.1	Gene:	Snm1 / 40669	FlyBaseID:	FBgn0037338	Length:	763	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	140/745 - (18%)
Similarity:	246/745 - (33%)	Gaps:	232/745 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PLP--------FVQSLKWSNLPNFVPSRDHDPQMDGELKDCCG--RVFVDSTPEFNL-------- 86
            |||        |..::|...:.:....|..||.:|.......|  |:|.:||...:.
  Fly    76 PLPGQMRIDSFFTSAVKNYKVKSSSSCRKVDPPLDKRKVSTKGRKRLFEESTTTSSAFTGKLDAK 140

  Fly    87 PMDKML------------DFSEVDVI--------LISNYLNMLALPYITENTGFKGKVYATEPTL 131
            |.:|.:            ..|||.||        .|....:.:|.| ..:::..:...:.|..|.
  Fly   141 PSEKRVQPSRRAKGKENASLSEVHVIDLCSEDEQTIKRKPSAIASP-CEKSSDVQATKFRTPETS 204

  Fly   132 QIGRFFLEELVDYIEVSP-----------KACTARLWKEKLHLLPSPLSE------AFRAKKWRT 179
            ..........:|.:|:||           ::..|.:.||      |||.:      ..:.:|.:.
  Fly   205 MPEAKLSNSSLDLVEISPGPNKSPTNNFYRSSPAAITKE------SPLGKNSKKGTVRKQRKPKP 263

  Fly   180 IFSLKDVQGSLSKVTIMGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAH--------EKICYV 236
            ....|.|:|:                 :|.......|...|.:::.|:..|        :|.|
  Fly   264 CPPYKVVEGT-----------------SFCVDGFQFGEIEGVTHYFLTHFHADHYIGLTKKFC-- 309

  Fly   237 SGSSTLTTHPRPINQSALKHADVLIMTGLTQAPTVNPDTKLGELCMNV-ALTIRNNGSALIPCY- 299
                    ||..::..:.:.....|....|....::.|..|....:.| ||...:...||:..:
  Fly   310 --------HPLYVSPISARLVRTFIKLDETHIHEIDVDQTLDVDGVQVTALEANHCPGALMFFFK 366

  Fly   300 -PSGVVYDLFECLTQNLE---NAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDP 360
             .||      ||:....:   :|.:.::|:|:         .:|||...:|.:...||.|    .
  Fly   367 LSSG------ECILHTGDFRASADMESLPIFW---------NHSNIDLLYLDTTYMNKNY----D 412

  Fly   361 FPH------------AFYLRNNKLKHY-----NHVFSE-----GFSKDF---------RQPCVVF 394
            |.|            ..:|..|..|..     ::|..:     ..:|:|         |...|..
  Fly   413 FCHQSESVDRAVDLVRAFLEKNAAKRILIVCGSYVIGKEKIWLALAKEFTMRVWTESNRSTAVRC 477

  Fly   395 CGHPSL-------RFGDAVHFIEMWGNNPNNSII--FTEPDFPYLQVLAPFQPLAMKAFYCP--- 447
            ...|.|       |.|..:|.|.| |.....|::  |||.:..| .:|...:|...:....|
  Fly   478 LNWPDLDSVLTEDRSGANLHVIAM-GKISYPSLVDYFTEFEDQY-DMLLGIRPSGWEKNSKPSYG 540

  Fly   448 --IDT-------SLNYQQANKLIKELKPNVLV--------------IPEAYTKPHPSAPNL---- 485
              |.|       ..:|::..:.::.|||..::              :|..:.|....|..|
  Fly   541 KRISTIGIEYSEHSSYKELERFVRFLKPKRVISTVPVGRDLYVTGEVPIRWYKYEGRASMLRTGF 605

  Fly   486 ------FIEQPDKKIITFKCG-EIIRLPLKRKLDRIYITSELAQKISPKEVAAGVTFSTLTGVLQ 543
                  |:..|.:....|... |:...|:.....:   .|| .:|...:|........|:
  Fly   606 QPSISTFLATPKRAFAKFSADTEMFLSPVDENASK---GSE-DKKDDDRESVVPTNHVTI----- 661

  Fly   544 VKD-KVHCIQPCADS---VKDETISSNSAPTKEDV--LKNVKYEYGSIDVDAVMKKLAQDGFSNI 602
            :.| ...|.|  .||   ||:|.::.:::|..|.|  |..::.|...:::|...:.:|.|
  Fly   662 ISDTPEECFQ--TDSKIPVKNEPLAPDTSPNSEIVAQLNAMESEIPYVEIDIKNETIAPD----- 719

  Fly   603 KLDRTGGALTLNLVNEDTVIKFEDNETHII 632
                  ..|...:..|||   |:..:.::|
  Fly   720 ------AVLIPRVPTEDT---FQSTDCNVI 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	50/286 (17%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983	34/166 (20%)
Snm1	NP_649548.1	SNM1A-1C-like_MBL-fold	252..408	CDD:293831	33/197 (17%)
Snm1	NP_649548.1	DRMBL	481..578	CDD:284854	22/98 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900