DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IntS9 and dclre1a

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001018385.4	Gene:	dclre1a / 324964	ZFINID:	ZDB-GENE-050522-124	Length:	926	Species:	Danio rerio

Alignment Length:	317	Identity:	63/317 - (19%)
Similarity:	108/317 - (34%)	Gaps:	112/317 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LYC--LSGDLAK-----------------PCYIITFKGLRI-MLDCGLTEQTVLNFLPLPFVQSL 47
            :||  ::.:|.|                 .|.:   :|::: :||........:....||..|::
Zfish   618 IYCNKVTSNLVKSKLKVDEQYIHVLPMNTECIV---QGVKVTLLDANHCPGAAMLLFVLPDGQTV 679

  Fly    48 KWSNLPNFVPSRDHDPQMDGELKDCCGRVFVDST---PEFNLPMDKMLDFSEVDVILISNYLNML 109
            ..:......||.:..|::.| |:  ...:::|:|   ||:..|       ::.:|:..:
Zfish   680 LHTGDFRADPSMERYPELQG-LR--IQTLYLDTTYCSPEYTFP-------TQQEVVTFA------ 728

  Fly   110 ALPYITENTGFKGKVYATEPTLQIGRFFLEELVDYIEVSPKAC-TARLWKEKLHLLPSPLSEAFR 173
                  .||.|: :|.....||.:                  | |..:.|||:.|   .:||...
Zfish   729 ------VNTAFE-RVTLNPRTLVV------------------CGTYSVGKEKVFL---AVSEVLS 765

  Fly   174 AK------KWRTIFSLKDVQGSLSKVTIMGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEK 232
            :|      |:.|:..|                |..|| |..|.|           ||..:..|..
Zfish   766 SKVCLSKDKYNTMCCL----------------ESEDI-GQRITT-----------NWQSAQVHVL 802

  Fly   233 ICYVSGSSTLTTHPRPINQSALKHADVLIM---TGLTQAPTVNPDTKLGELCMNVAL 286
            .........|.||.:..:    |..|.|:.   ||.|...||..|..|.:...|:::
Zfish   803 PMMQINFKNLQTHLKKFS----KKYDQLVAFKPTGWTFNQTVGVDDILPQTQGNISI 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	55/293 (19%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983
dclre1a	NP_001018385.4	SNM1A-like_MBL-fold	558..714	CDD:293856	18/101 (18%)
dclre1a	NP_001018385.4	DRMBL	785..888	CDD:284854	22/87 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900