DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IntS9 and cpsf3

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001003836.1	Gene:	cpsf3 / 324554	ZFINID:	ZDB-GENE-030131-3275	Length:	690	Species:	Danio rerio

Alignment Length:	501	Identity:	104/501 - (20%)
Similarity:	189/501 - (37%)	Gaps:	144/501 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCC 73
            ::.:.|.|:.|||.:||:|||:                               .|.::|
Zfish    29 EVGRSCIILEFKGRKIMVDCGI-------------------------------HPGLEG------ 56

  Fly    74 GRVFVDSTPEFNLPMDKMLDFSEVDVILISNYL--NMLALPYITENTGFKGKVYATEPTLQIGRF 136
                :|:.|..:|     :|.:|:|::|||::.  :..|||:..:.|.|||:.:.|..|..|.|:
Zfish    57 ----MDALPYIDL-----IDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRW 112

  Fly   137 FLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVTIMGYDEK 201
            .|.   ||::||..:....|:.|                        .|::.|:.|:..:.:.|.
Zfish   113 LLS---DYVKVSNISADDMLYTE------------------------TDLEESMDKIETINFHEV 150

  Fly   202 LDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSALKHADVLIMTGLT 266
            .::.|..... ..:|:.||::.:::..|..|:.|....|              :..|..:|.  .
Zfish   151 KEVAGIKFWC-YHAGHVLGAAMFMIEIAGVKLLYTGDFS--------------RQEDRHLMA--A 198

  Fly   267 QAPTVNPDTKLGE-----------------LCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQN 314
            :.|:|.||..:.|                 .|..|...:...|..|||.:..|...:|...|.:.
Zfish   199 EIPSVKPDILITESTYGTHIHEKREEREARFCNTVHDIVNREGRCLIPVFALGRAQELLLILDEY 263

  Fly   315 LEN-AGLNNVPMFFISPVADSSLA----YSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKH 374
            .:| ..|:::|:::.|.:|...:|    |.|.:.:     |..|....::||   .:...:.||.
Zfish   264 WQNHPELHDIPIYYASSLAKKCMAVYQTYVNAMND-----KIRKAININNPF---VFKHISNLKS 320

  Fly   375 YNHVFSEGFSKDFRQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSI--------------IFTEP 425
            .:|....|       |.||......::.|.:....|.|..:..|.:              |.:||
Zfish   321 MDHFDDIG-------PSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEP 378

  Fly   426 DFPYLQVLAPFQPLAMKAFYCPIDTSLNYQQANKLIKELKPNVLVI 471
            : ....:.....||.|...|.......:|||.::.|:.|||..:::
Zfish   379 E-EITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRALKPPHVIL 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	53/256 (21%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983	28/142 (20%)
cpsf3	NP_001003836.1	CPSF3-like_MBL-fold	19..212	CDD:293850	57/272 (21%)
		YSH1	21..461	CDD:224157	104/501 (21%)
		Beta-Casp	253..374	CDD:214983	25/135 (19%)
		RMMBL	387..427	CDD:284853	11/37 (30%)
		CPSF73-100_C	485..638	CDD:288554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810