DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS9 and Cpsf2

DIOPT Version :9

Sequence 1:	NP_648838.3	Gene:	IntS9 / 39763	FlyBaseID:	FBgn0036570	Length:	654	Species:	Drosophila melanogaster
Sequence 2:	NP_001100223.1	Gene:	Cpsf2 / 299256	RGDID:	1309687	Length:	782	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	154/755 - (20%)
Similarity:	262/755 - (34%)	Gaps:	243/755 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLYCLSG--DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDP 63
            ::|..|||  :.:..||::.....|.:||||..|.     ..:..:.||           |.|
  Rat     5 IKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEH-----FSVDIIDSL-----------RKH-- 51

  Fly    64 QMDGELKDCCGRVFVDSTPEFNLPMDKMLDFSEVDVILIS--NYLNMLALPYITENTGFKGKVYA 126
                                          ..::|.:|:|  :.|::.|||:.....|....:||
  Rat    52 ------------------------------VHQIDAVLLSHPDPLHLGALPFAVGKLGLNCAIYA 86

  Fly   127 TEPTLQIGRFFLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLS 191
            |.|..::|:.|:.:|.                :..|     .:|.|      |:|:|.||..:..
  Rat    87 TIPVYKMGQMFMYDLY----------------QSRH-----NTEDF------TLFTLDDVDAAFD 124

  Fly   192 KVTIMGYDEKLDILG---AFIATPVSSGYCLGSSNW-VLSTAHEKICYVSGSSTLTTHPRPINQS 252
            |:..:.:.:.:::.|   ....||:.:|:.:|.:.| ::....|:|.|....:    |.|.|:.:
  Rat   125 KIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFN----HKREIHLN 185

  Fly   253 A----LKHADVLIMTGLTQAPTVNPDTKL--GELCMNVALTIRNNGSALIPCYPSGVVYDLFECL 311
            .    :.....|::|....|..|.|..|.  .:|..||..|:|.:|:.||....:|.|.:|.:.|
  Rat   186 GCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLL 250

  Fly   312 TQ--NLENAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKH 374
            .|  ..::|||....:..::.|:.:.:.:|....||:|           |.....|..:.|....
  Rat   251 DQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMS-----------DKLMRCFEDKRNNPFQ 304

  Fly   375 YNHV-FSEGFSKDFR--QPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYLQVLAPF 436
            :.|: ...|.|...|  .|.||....|.|..|.:......|..:|.||||.|....|  ..||.|
  Rat   305 FRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTP--GTLARF 367

  Fly   437 QPLAMKAFYCPID------TSL--------------NYQQANKLIKELKPNV------------- 468
            .          ||      |.:              .|.:..||.||....:
  Rat   368 L----------IDNPSEKVTEIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADIDSSDE 422

  Fly   469 ------LVIPEAYTKPHP-------SAPNLFIEQ----------PDKKIITFKCGEIIRLPLKRK 510
                  :..|.|:...|.       |....|.:|          |:::|...:.||||: |....
  Rat   423 SDVEEDVDQPTAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIK-PEDFL 486

  Fly   511 LDRIYITSELAQKISPKEVAAGVTFS----------------TLTGVLQVKDKVHCI----QPCA 555
            :..:..|.|...|:.     :|:|..                :.|..:::|.:|..|    :...
  Rat   487 VPELQATEEEKSKLE-----SGLTNGEEPMDQDLSDVPTKCVSATESIEIKARVTYIDYEGRSDG 546

  Fly   556 DSVKD--------ETISSNSAPTKEDVLKNVKYEYGSIDVDAVMKKLAQDGFSNIKLDRTGGALT 612
            ||:|.        :.|..:..|.....|......:|..|:...|.||.:      .:|.|
  Rat   547 DSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHE------TVDAT----- 600

  Fly   613 LNLVNEDTVIKFEDNETHIICGGKPTTRLKLRDTIMKCLQ 652
                          :||||.       :::|:|:::..||
  Rat   601 --------------SETHIY-------QVRLKDSLVSSLQ 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:304873	53/274 (19%)
IntS9	NP_648838.3	Beta-Casp	304..428	CDD:214983	32/128 (25%)
Cpsf2	NP_001100223.1	CPSF2-like_MBL-fold	7..204	CDD:293851	54/275 (20%)
		Beta-Casp	243..368	CDD:214983	35/137 (26%)
		RMMBL	529..591	CDD:400070	11/61 (18%)
		CPSF100_C	608..779	CDD:404222	4/12 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1236
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810