Protein Alignment IntS9 and ints-11

DIOPT Version :10

• Sequence 1: NP_648838.3
• Gene: IntS9 / 39763
• FlyBaseID: FBgn0036570
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: NP_495706.2
• Gene: ints-11 / 174310
• WormBaseID: WBGene00008642
• Length: 608
• Species: Caenorhabditis elegans
• Alignment Length: 693
• Identity: 138/693 - (19%)
• Similarity: 245/693 - (35%)
• Gaps: 196/693 - (28%)

  Fly     9 DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCC 73
            |:.:.|.:||..|..||:|||:                              |....|
 Worm    18 DVGRSCILITIGGKNIMVDCGM------------------------------HMGYQD------- 45

  Fly    74 GRVFVDSTPEFNL--PMDKMLDFSEVDVILISNYL--NMLALPYITENTGFKGKVYATEPTLQIG 134
            .|.|    |:|:.  ...::.|:  :|.::||::.  :..:||:::|..|:.|.:|.|.||..|.
 Worm    46 DRRF----PDFSYIGGGGRLTDY--LDCVIISHFHLDHCGSLPHMSEIVGYDGPIYMTYPTKAIC 104

  Fly   135 RFFLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVT----- 194
            ...||   ||.:|.   |.                    .|.....|:..|::..:.||.
 Worm   105 PVLLE---DYRKVQ---CD--------------------IKGETNFFTSDDIKNCMKKVVGCALH 143

  Fly   195 -IMGYDEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVS----------GSSTLTTHPRP 248
             |:..|.:|.| .||.|     |:.||::.:.:......:.|..          |::.:....||
 Worm   144 EIIHVDNELSI-RAFYA-----GHVLGAAMFEIRLGDHSVLYTGDYNMTPDRHLGAARVLPGVRP 202

  Fly   249 INQSALKHADVLIMTGLTQAPTVNPDTKLGE--LCMNVALTIRNNGSALIPCYPSGVVYDLFECL 311
                      .::::..|.|.|:....:..|  ....|...:...|..:||.:..|...:|...|
 Worm   203 ----------TVLISESTYATTIRDSKRARERDFLRKVHECVMKGGKVIIPVFALGRAQELCILL 257

  Fly   312 TQNLENAGLNNVPMFFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYN 376
            ....|...| |||::|...:|:.:..|..:...| ::....|.::..:.|         :.||..
 Worm   258 ESYWERMAL-NVPIYFSQGLAERANQYYRLFISW-TNENIKKTFVERNMF---------EFKHIK 311

  Fly   377 HVFSEGFSKDFRQPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIFTEPDFPYLQVLAPFQPLAM 441
            .:  |...:|...|.|:|.....|..|.::...:.|.::|.|.||...
 Worm   312 PM--EKGCEDQPGPQVLFSTPGMLHGGQSLKVFKKWCSDPLNMIIMPG----------------- 357

  Fly   442 KAFYCPIDT----SLNYQQANKLIKELKPNVLVIPEAYTKPHPSAPNL--FIEQPDKKIITFKCG 500
               ||...|    .:|.::..::.:::....|.:.......|..|..:  .|.|.:.:.:.|..|
 Worm   358 ---YCVAGTVGARVINGEKKIEIDQKMHEIRLGVEYMSFSAHADAKGIMQLIRQCEPQHVMFVHG 419

  Fly   501 EIIRLP-LKRKLDRIYITSELAQKISPKEVAAGVTFSTLTGVLQVKDKVHCIQP----------- 553
            |..::. ||.|:::.|       |:.....|.|.|.     |:..:.|:....|
 Worm   420 EASKMEFLKGKVEKEY-------KVPVHMPANGETV-----VISAQPKLDIRVPLEKIDRSLSLD 472

  Fly   554 -------C---ADSVKD---ETISSNSAPTKEDVLKNVKYEYGSIDVDAVM--KKLAQDGFSNIK 603
                   |   |:.|.|   |.::..|....||::|:......::.:..::  ||:.....||
 Worm   473 PNPAKSECPFVAELVYDQENERLNIMSTAESEDLIKDKNCMPITLSLSEIIKGKKVNWKELSN-- 535

  Fly   604 LDRTGGALTL---NLVNEDTVIKFEDNETHIICGGKPTTRLKL 643
                  .|.|   :|..:|..|:..|.|..|:......|.|:|
 Worm   536 ------ELLLYDPHLQLKDDGIEMFDGEITILANNSDETELEL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:451500	55/274 (20%)
		Beta-Casp	304..428	CDD:214983	27/123 (22%)
ints-11	NP_495706.2	YSH1	9..422	CDD:440849	103/521 (20%)
		INTS11-like_MBL-fold	10..209	CDD:293849	55/275 (20%)