Protein Alignment IntS9 and IntS11

DIOPT Version :10

• Sequence 1: NP_648838.3
• Gene: IntS9 / 39763
• FlyBaseID: FBgn0036570
• Length: 654
• Species: Drosophila melanogaster
• Sequence 2: XP_319042.4
• Gene: IntS11 / 1279335
• VectorBaseID: AGAMI1_000330
• Length: 608
• Species: Anopheles gambiae
• Alignment Length: 696
• Identity: 140/696 - (20%)
• Similarity: 249/696 - (35%)
• Gaps: 197/696 - (28%)

  Fly     9 DLAKPCYIITFKGLRIMLDCGLTEQTVLNFLPLPFVQSLKWSNLPNFVPSRDHDPQMDGELKDCC 73
            |:.:.|.:::..|..||||||:               .:.:::...|
Mosquito    14 DVGRSCILLSMAGKNIMLDCGM---------------HMGYNDERRF------------------ 45

  Fly    74 GRVFVDSTPEFNLPMDKMLDFSEVDVILISNYL--NMLALPYITENTGFKGKVYATEPTLQIGRF 136
                    |:|:..:.:....:.:|.::||::.  :..||||:||..|:.|.:|.|.||..|...
Mosquito    46 --------PDFSFIIPEGPITNHIDCVIISHFHLDHCGALPYMTEMVGYTGPIYMTHPTKAIAPI 102

  Fly   137 FLEELVDYIEVSPKACTARLWKEKLHLLPSPLSEAFRAKKWRTIFSLKDVQGSLSKVTI---MGY 198
            .||:: ..:.|..|.       |.....|.               .:||....:..||:   :..
Mosquito   103 LLEDM-RKVAVERKG-------ESNFFTPQ---------------MIKDCMKKVIAVTLHQSVMV 144

  Fly   199 DEKLDILGAFIATPVSSGYCLGSSNWVLSTAHEKICYVSGSSTLTTHPRPINQSAL-KHADVLIM 262
            |.:|:|...:      :|:.||::.:.:....:.:.| :|...:|. .|.:..:.: |....|::
Mosquito   145 DSELEIKAYY------AGHVLGAAMFWIRVGSQSVVY-TGDYNMTP-DRHLGAAWIDKCKPDLLI 201

  Fly   263 TGLTQAPTVNPDTKLGE--LCMNVALTIRNNGSALIPCYPSGVVYDLFECLTQNLENAGLNNVPM 325
            |..|.|.|:....:..|  ....|...:...|..|||.:..|...:|...|....|...| ..|:
Mosquito   202 TESTYATTIRDSKRCRERDFLKKVHECVAKGGKVLIPVFALGRAQELCILLETYWERMNL-KYPV 265

  Fly   326 FFISPVADSSLAYSNILAEWLSSAKQNKVYLPDDPFPHAFYLRNNKLKHYNHV--FSEGFSKDFR 388
            :|...:.:.:..|..:...| ::.|..|.::..:.|            .:.|:  |.:|:. |..
Mosquito   266 YFAVGLTEKANNYYKMFITW-TNQKIRKTFVQRNMF------------DFKHIKPFDKGYI-DNP 316

  Fly   389 QPCVVFCGHPSLRFGDAVHFIEMWGNNPNNSIIF-----------------TEPDFPYLQVLAPF 436
            ...|||.....|..|.::...:.|..|.||.:|.                 .:.:|...||:
Mosquito   317 GAMVVFATPGMLHAGLSLQIFKKWAPNENNMVIMPGYCVQGTVGHKILGGAKKVEFENRQVV--- 378

  Fly   437 QPLAMKAFYCPIDTSLNYQQANKLIKELKP-NVLVIPEAYTKPHPSAPNLFIEQPDKKIITFKCG 500
             .:.|...|.......:.:...:||:..:| ||:::       |                    |
Mosquito   379 -DVKMSVEYMSFSAHADAKGIMQLIQFCEPRNVMLV-------H--------------------G 415

  Fly   501 EIIRLP-LKRKLDRIYITSELAQKISPKEVAAGVTFSTLTGVLQVKDKVHCIQPCADSVKDETIS 564
            |.:::. ||.|:...:       ||.....|.|.|.:..|.:     |:. ::.....:|||...
Mosquito   416 EAVKMEFLKEKIREEF-------KIECYTPANGETCTISTPI-----KIP-VETSLSILKDEVKK 467

  Fly   565 SNSAPTKED---------VLKNVKYEYGSIDV---DAVMKKLAQDGFSNIKLD------RT---- 607
            .|:.|....         |:|:.|....|||.   :|.:.:......|.||||      ||
Mosquito   468 YNAQPPDPKRRRIIHGILVMKDNKISLMSIDEIFNEAGIDRHVIRFISKIKLDDPGPPMRTIEKL 532

  Fly   608 ---------GGALTL---NLVNEDTV-IKFEDNETHIICG--GKPT 638
                     |..:|:   |.:|.::| ||.|..|.....|  |:|:
Mosquito   533 YNMLNERLSGWTVTMNDNNSINVESVNIKIETEEQPAAIGSVGQPS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS9	NP_648838.3	metallo-hydrolase-like_MBL-fold	1..264	CDD:451500	50/260 (19%)
		Beta-Casp	304..428	CDD:214983	25/142 (18%)
IntS11	XP_319042.4	YSH1	5..416	CDD:440849	97/519 (19%)
		INTS11-like_MBL-fold	6..204	CDD:293849	51/261 (20%)